Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries

1992 ◽  
Vol 7 (2) ◽  
pp. 114-118 ◽  
Author(s):  
A.M. Mileo ◽  
M. Fanuele ◽  
F. Battaglia ◽  
G. Scambia ◽  
C. Benedetti-Panici ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Preliminary Evaluation ◽  
Apparent Difference ◽  
Her 2 ◽  
Epidermal Growth ◽  
Neu Oncogene

The HER-2/neu oncogene (a member of the Erb-like oncogene family) is distinct from but closely related to the c-erb B gene which encodes the epidermal growth factor receptor (EGFr). HER-2/neu gene amplification was found in a large number of mammary carcinomas and there was a strong correlation between this phenomenon and poor prognosis. In our study HER-2/neu oncogene expression was determined in 16 malignant ovarian tumors, 2 ovarian lymphomas and 5 normal ovaries. The HER-2/neu gene was found both in normal ovaries and malignant tumors, without any apparent difference among the various histological types. In all the specimens examined, HER-2/neu expression did not seem to be related to EGF binding capacity.

Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries

1992 ◽  
Vol 7 (1) ◽  
pp. 47-51 ◽  
Author(s):  
A.M. Mileo ◽  
M. Fanuele ◽  
F. Battaglia ◽  
G. Scambia ◽  
C. Benedetti-Panici ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Preliminary Evaluation ◽  
Apparent Difference ◽  
Her 2 ◽  
Epidermal Growth ◽  
Neu Oncogene

The HER-2/neu oncogene (a member of the Erb-like oncogene family) is distinct from but closely related to the c-erb B gene which encodes the epidermal growth factor receptor (EGFr). HER-2/neu gene amplification was found in a large number of mammary carcinomas and there was a strong correlation between this phenomenon and poor prognosis. In our study HER-2/neu oncogene expression was determined in 16 malignant ovarian tumors, 2 ovarian lymphomas and 5 normal ovaries. The HER-2/neu gene was found both in normal ovaries and malignant tumors, without any apparent difference among the various histological types. In all the specimens examined, HER-2/neu expression did not seem to be related to EGF binding capacity.

scholarly journals Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes

Cancer ◽  
2010 ◽  
Vol 116 (5) ◽  
pp. 1234-1242 ◽  
Author(s):  
Mothaffar F. Rimawi ◽  
Priya B. Shetty ◽  
Heidi L. Weiss ◽  
Rachel Schiff ◽  
C. Kent Osborne ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Clinical Outcomes ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Epidermal Growth

Effectiveness and safety of eribulin for human epidermal growth factor receptor 2 negative metastatic breast cancer in a real-world population

2021 ◽  
pp. 107815522110382
Author(s):  
Rocío Díaz-Acedo ◽  
Silvia Artacho Criado ◽  
Rocío Jiménez Galán ◽  
Antonio Gutiérrez Pizarraya ◽  
Mercedes Galván Banqueri ◽  
...  
Keyword(s):  
Overall Survival ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Confidence Interval ◽  
Median Overall Survival ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Human Epidermal Growth Factor ◽  
Epidermal Growth

Background Eribulin’s clinical benefit remains unclear; so, studies analyzing its effectiveness in routine clinical practice are interesting. Patients and methods This is a multicenter, retrospective study including patients with human epidermal growth factor receptor-2-negative metastatic breast cancer which assesses effectiveness and safety of eribulin. Results A total of 140 women were included, with a median age of 57 years. The median overall survival and progression-free survival were 8.8 (95% confidence interval: 6.1–11.4) and 2.8 months (95% confidence interval: 2.5–3.1), respectively. For patients with hormonal receptor expression, a significantly longer progression-free survival was observed: 3.4 (95%confidence interval: 2.3–4.5) versus triple negative: 2.0 (95%confidence interval: 1.7–2.3) months, p = 0.003. Also, those who had received capecitabine prior to eribulin had a higher median overall survival than those who had not received it (9.5 months, 95% confidence interval: 6.6–12.5 vs. 4.8 months, 95% confidence interval: 3.4–6.2; p = 0.001). When only triple-negative patients were included, median overall survival was 6.5 (95% confidence interval: 0.1–16.2) for those who had received previous capecitabine versus 4.3 (95% confidence interval: 2.8–5.8) months for patients who had not received it; p =0.006. The safety profile of eribulin was adequate. Conclusion Effectiveness of eribulin in a real-life human epidermal growth factor receptor-2--negative population is lower than that observed in clinical trials. Its benefit seems to be higher in patients with hormonal receptor expression and patients who had received capecitabine prior to eribulin. The safety profile of eribulin is adequate.

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