scholarly journals Multipotent adult progenitor cells on an allograft scaffold facilitate the bone repair process

2016 ◽  
Vol 7 ◽  
pp. 204173141665614 ◽  
Author(s):  
Amanda LoGuidice ◽  
Alison Houlihan ◽  
Robert Deans
Keyword(s):  
Progenitor Cells ◽  
Bone Repair ◽  
Repair Process ◽  
Multipotent Adult Progenitor Cells

scholarly journals Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Kiyotaka Okada ◽  
Minoru Nishioka ◽  
Hiroshi Kaji
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Growth Factor ◽  
Bone Resorption ◽  
Progenitor Cells ◽  
Bone Remodeling ◽  
Bone Repair ◽  
Repair Process ◽  
Hematopoietic Stem ◽  
Bone Injury

Abstract In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are expressed in osteoclasts and osteoblasts, and are involved in bone remodeling through bone resorption and formation. The repair/regeneration process after bone injury is divided into the acute inflammatory, repair, and remodeling stages. Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells (HSPCs) and mesenchymal stem cells (MSCs) in the bone marrow. Therefore, stem cells in the bone marrow may be strongly influenced by bone injury. The urokinase-type PA (u-PA)/plasminogen (Plg) system functions in macrophage accumulation/phagocytosis through chemokines in the acute inflammatory stage, and Plg increases blood vessel-related growth factor expression, being involved in vascularization in mice. Plasminogen activator inhivitor-1 (PAI-1) causes bone loss and delayed bone repair through the inhibition of osteoblast differentiation in a drug-induced diabetes model in mice. Plg is considered to induce transforming growth factor-β (TGF-β) production in macrophages in the bone repair process, TGF-β release from the extracellular matrix through the activation of matrix metalloproteinase-9 (MMP-9), and stromal cell-derived factor-1 (SDF-1) expression in endosteal preosteoblasts, leading to the induction of bone marrow HSPCs in mice. Based on the above, establishment of a fibrinolytic factor-targeting method efficiently promoting bone repair/regeneration and fracture healing, and development of a new osteoporosis treatment method and diagnostic marker are awaited.

scholarly journals Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells

2013 ◽  
Vol 91 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Sandra A Jacobs ◽  
Valerie D Roobrouck ◽  
Catherine M Verfaillie ◽  
Stefaan W Van Gool
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Human Mesenchymal Stem Cells ◽  
Multipotent Adult Progenitor Cells

Enhancement of Bone Healing by Local Administration of Carbon Nanotubes Functionalized with Sodium Hyaluronate in Rat Tibiae

2017 ◽  
Vol 204 (3-4) ◽  
pp. 137-149 ◽  
Author(s):  
Vanessa B. Andrade ◽  
Marcos A. Sá ◽  
Renato M. Mendes ◽  
Paulo A. Martins-Júnior ◽  
Gerluza A.B. Silva ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Repair ◽  
Bone Matrix ◽  
Sodium Hyaluronate ◽  
Repair Process ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Bone Trabeculae ◽  
Endothelial Growth Factor

It has been reported that carbon nanotubes (CNTs) serve as nucleation sites for the deposition of bone matrix and cell proliferation. Here, we evaluated the effects of multi-walled CNTs (MWCNTs) on bone repair of rat tibiae. Furthermore, because sodium hyaluronate (HY) accelerates bone restoration, we associated CNTs with HY (HY-MWCNTs) in an attempt to boost bone repair. The bone defect was created by a 1.6-mm-diameter drill. After 7 and 14 days, tibiae were processed for histological and morphometric analyses. Immunohistochemistry was used to evaluate the expression of vascular endothelial growth factor (VEGF) in bone defects. Expression of osteocalcin (OCN), bone morphogenetic protein-2 (BMP-2), and collagen I (Col I) was assessed by real-time PCR. Histomorphometric analysis showed a similar increase in the percentage of bone trabeculae in tibia bone defects treated with HY and HY-MWCNTs, and both groups presented more organized and thicker bone trabeculae than nontreated defects. Tibiae treated with MWCNTs or HY- MWCNTs showed a higher expression of VEGF. Treatment with MWCNTs or HY-MWCNTs increased the expression of molecules involved in the bone repair process, such as OCN and BMP-2. Also, HY- and MWCNT-treated tibiae had an increased expression of Col I. Thus, it is tempting to conclude that CNTs associated or not with other materials such as HY emerged as a promising biomaterial for bone tissue engineering.

Multipotent Adult Progenitor Cells (MAPC) contribute to hepatocarcinoma neovasculature

2007 ◽  
Vol 364 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Miguel Barajas ◽  
Federico Franchi ◽  
Carlos Clavel ◽  
Xabier L. Aranguren ◽  
M. Gabriela Kramer ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Multipotent Adult Progenitor Cells

Multipotent Adult Progenitor Cells

2014 ◽  
pp. 245-253
Author(s):  
Philip R. Roelandt ◽  
Valerie D. Roobrouck ◽  
Catherine M. Verfaillie
Keyword(s):  
Progenitor Cells ◽  
Multipotent Adult Progenitor Cells

scholarly journals Alginate encapsulated multipotent adult progenitor cells promote corneal stromal cell activation via release of soluble factors

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0202118 ◽  
Author(s):  
Olla Al-Jaibaji ◽  
Stephen Swioklo ◽  
Kristel Gijbels ◽  
Bart Vaes ◽  
Francisco C. Figueiredo ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Stromal Cell ◽  
Cell Activation ◽  
Soluble Factors ◽  
Multipotent Adult Progenitor Cells
Sign in / Sign up

Export Citation Format

Share Document