scholarly journals A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma

JRSM Open ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 205427042098362
Author(s):  
Andrew Coppola ◽  
Chia Chey ◽  
Emma O’Donovan ◽  
Monira Rahman

Acute liver failure is a life-threatening condition commonly caused by drug-induced hepatotoxicity or viral hepatitides. However, there are a number of rarer causes such as haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis is a syndrome of uncontrolled immune cell activation, triggered by infection or malignancy, which carries a high mortality. Whilst mild to moderate liver injury is commonly seen with haemophagocytic lymphohistiocytosis, acute liver failure has rarely been reported in adults. We present a case of a 74-year-old man with acute liver failure secondary to haemophagocytic lymphohistiocytosis triggered by undiagnosed large B-cell lymphoma. Initially treated for biliary sepsis, there was a delay in the diagnosis of haemophagocytic lymphohistiocytosis and despite initiating chemotherapy, he died soon after. This case highlights the importance of considering haemophagocytic lymphohistiocytosis as a rare cause of acute liver failure, as given the life-threatening potential of haemophagocytic lymphohistiocytosis, a prompt diagnosis may allow early initiation of chemotherapy for any chance of survival.

2015 ◽  
Vol 2015 (may12 1) ◽  
pp. bcr2015209328-bcr2015209328 ◽  
Author(s):  
D. Kapuria ◽  
K. Strasser ◽  
A. Qasem

2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Sofia Grille ◽  
Matilde Boada ◽  
Virginia Bove ◽  
Daniel Leal ◽  
Andreina Brugnini ◽  
...  

2020 ◽  
Vol 13 (6) ◽  
pp. 1213-1218
Author(s):  
Kimitoshi Kubo ◽  
Noriko Kimura ◽  
Katsuhiro Mabe ◽  
Soichiro Matsuda ◽  
Momoko Tsuda ◽  
...  

AbstractAcute liver failure (ALF) associated with malignant infiltration of the liver is rare and its pathological and radiologic features remain poorly described. An 87-year-old man was admitted to our hospital for anorexia for several days, high-grade fever from the previous day, and liver dysfunction but suddenly died on day 3 of hospitalization due to ventricular fibrillation. The patient was diagnosed at autopsy with malignant diffuse large B-cell lymphoma. To the best of our knowledge, this report represents a valuable addition to the ALF literature describing a case of ALF associated with diffuse large B-cell lymphoma diagnosed at autopsy.


2021 ◽  
Vol 8 (8) ◽  
Author(s):  
Rao RL ◽  
◽  
Hornstein N ◽  
Britten K ◽  
Ghafour SN ◽  
...  

Diffuse Large B-Cell Lymphoma (DLBCL) is the most common histologic subtype of lymphoma. Affected patients most commonly present with rapid lymph node enlargement in the neck, abdomen, or chest, with extranodal disease occurring in up to 40% of all cases. Generally, DLBCL is a clinically aggressive malignancy and the presence of extranodal disease is a poor prognostic indicator. Acute Liver Failure (ALF) is a rare presentation of extranodal DLBCL that is typically associated with a bleak prognosis; however, the impact of prompt diagnosis followed by initiation of appropriate chemotherapy in this setting is not well understood. Further complicating treatment, first-line chemotherapy regimens for DLBCL are typically contraindicated in the setting of liver failure. In this case report, we describe the successful treatment of DLBCL originally presenting as ALF through bridging therapy with a non-standard bendamustinebased approach.


2020 ◽  
Vol 115 (1) ◽  
pp. S1266-S1266
Author(s):  
Natalie C. Penn ◽  
Anjanet Perez-Colon ◽  
Claire Porterfield ◽  
Mark A. Levstik

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