scholarly journals Successful treatment and long-term follow up of idiopathic immune-mediated polyarthritis with mycophenolate mofetil in a cat

2020 ◽  
Vol 6 (2) ◽  
pp. 205511692096399
Author(s):  
Yu Tamura ◽  
Tetsuro Nagamoto ◽  
Kazuhito Segawa ◽  
Sakurako Neo ◽  
Hirotaka Igarashi ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Synovial Fluid ◽  
Successful Treatment ◽  
Clinical Signs ◽  
Limited Information ◽  
Amyloid A ◽  
Immune Mediated ◽  
Long Term Follow Up

Case summary A 7-year-old neutered male Norwegian Forest Cat was presented with decreased appetite and activity, weight loss, fever, neutrophilia and hyperglobulinaemia. A physical examination showed painful stifle joints and enlarged popliteal lymph nodes. Blood examination showed neutrophilia, hyperglobulinaemia and increased serum amyloid A. Urinalysis, thoracic and abdominal radiographs, and abdominal ultrasonography were unremarkable. Synovial fluid from the knee joints had diminished viscosity and revealed neutrophilic inflammation on the smear. There was no evidence of infection in a microbiological culture of the synovial fluid. A diagnosis of idiopathic immune-mediated polyarthritis (IMPA) was made. Prednisolone was initiated at 2 mg/kg q24h PO and tapered with additional immunosuppressants (leflunomide, ciclosporin A and methotrexate); however, prednisolone could not be discontinued. Informed consent was obtained from the owner and mycophenolate mofetil (MMF) at a dosage of 10 mg/kg q12h PO was initiated on day 798. There were no adverse effects of MMF and prednisolone was discontinued on day 1183. Clinical signs resolved and the cat’s general condition remained stable with MMF alone at a dosage of 10 mg/kg q48h PO on day 1600. Relevance and novel information There is limited information describing feline IMPA and its treatment options other than the use of prednisolone. This is the first report of the successful treatment and long-term follow-up of feline IMPA with MMF. MMF may be a safe and effective option as an additional immunosuppressant in feline IMPA.

Aseptic Suppurative Meningitis in Juvenile Boxer Dogs: Retrospective Study of 12 Cases

2006 ◽  
Vol 42 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Sebastien Behr ◽  
Laurent Cauzinille
Keyword(s):  
Complete Resolution ◽  
Clinical Presentation ◽  
Immunosuppressive Treatment ◽  
Clinical Signs ◽  
Central Nervous System Inflammation ◽  
Immune Mediated ◽  
Long Term Follow Up ◽  
Boxer Dogs

Immune-mediated central nervous system inflammation is described in a series of 12 juvenile boxer dogs. A diagnosis of steroid-responsive meningitis-arteritis was made based on the clinical presentation and on diagnostic findings. The boxer breed was at a higher risk for this inflammatory condition than other breeds. Long-term follow-up (>2 years) confirmed a better prognosis in this breed than in the beagle and the Bernese mountain dog. Complete resolution of clinical signs without significant deficits or recurrences was obtained in all cases. Early clinical recognition and immunosuppressive treatment resulted in a better response and complete resolution of the disorder.

Successful treatment of hepatitis C reinfection with interferon-alpha2b and ribavirin after liver transplantation. A long-term follow-up.

2005 ◽  
Vol 25 (4) ◽  
pp. 717-722 ◽  
Author(s):  
Suleyman Yedibela ◽  
Detlef Schuppan ◽  
Volker Muller ◽  
Vera Schellerer ◽  
Andrea Tannapfel ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C ◽  
Successful Treatment ◽  
Long Term Follow Up ◽  
Hepatitis C Reinfection

scholarly journals Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis

2015 ◽  
Vol 75 (3) ◽  
pp. 526-531 ◽  
Author(s):  
Farah Tamirou ◽  
David D'Cruz ◽  
Shirish Sangle ◽  
Philippe Remy ◽  
Carlos Vasconcelos ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Lupus Nephritis ◽  
Positive Predictive Value ◽  
Maintenance Therapy ◽  
Early Response ◽  
Renal Outcome ◽  
Proliferative Lupus Nephritis ◽  
Long Term Follow Up

ObjectiveTo report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome.MethodsIn 2014, data on survival, kidney function, 24 h proteinuria, renal flares and other outcomes were collected for the 105 patients randomised between 2002 and 2006, except in 13 lost to follow-up.ResultsDeath (2 and 3 in the AZA and MMF groups, respectively) and end-stage renal disease (1 and 3, respectively) were rare events. Time to renal flare (22 and 19 flares in AZA and MMF groups, respectively) did not differ between AZA and MMF patients. Patients with good long-term renal outcome had a much more stringent early decrease of 24 h proteinuria compared with patients with poor outcome. The positive predictive value of a 24 h proteinuria <0.5 g/day at 3 months, 6 months and 12 months for a good long-term renal outcome was excellent (between 89% and 92%). Inclusion of renal function and urinalysis in the early response criteria did not impact the value of early proteinuria decrease as long-term prognostic marker.ConclusionsThe long-term follow-up data of the MAINTAIN Nephritis Trial do not indicate that MMF is superior to AZA as maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis. Moreover, we confirm the excellent positive predictive value of an early proteinuria decrease for long-term renal outcome.Trial registration numberNCT00204022.

Esthetic Restorative Options for Pulpotomized Primary Molars: A Review of Literature

2011 ◽  
Vol 36 (2) ◽  
pp. 123-126 ◽  
Author(s):  
Marcio Guelmann ◽  
Joseph Shapira ◽  
Daniela Silva ◽  
Anna Fuks
Keyword(s):  
Hybrid Composites ◽  
Primary Molars ◽  
Glass Ionomer ◽  
Limited Information ◽  
Resin Modified Glass Ionomer ◽  
Alternative Materials ◽  
Long Term Follow Up ◽  
Better Than

Objective: The goal of this manuscript was to review the existing literature in regards to esthetic options to restore pulpotomized primary molars. Study design: A pubmed literature search has been performed and all relevant studies were assessed. Results: Two laboratory, 3 restrospective and 4 prospective clinical studies were found, reviewed and analyzed. Conclusions: Based on the limited information available, we concluded that tooth colored and bonded restorations showed promising results as alternative materials to replace stainless steel crowns after pulpotomies in primary molars. Hybrid composites tend to perform better than compomers. Resin modified glass ionomer cements demonstrated excellent marginal seal and retention. More long-term follow up studies are necessary until more definitive recommendations can be made.

Frantz's tumor (solid and cystic tumor of the pancreas) with liver metastasis: Successful treatment and long-term follow-up

1995 ◽  
Vol 30 (5) ◽  
pp. 724-726 ◽  
Author(s):  
Minoru Horisawa ◽  
Noriji Nijnomi ◽  
Taichiro Sato ◽  
Syunpei Yokoi ◽  
Koji Oda ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Successful Treatment ◽  
Cystic Tumor ◽  
Long Term Follow Up ◽  
Solid And Cystic Tumor

Feline ischaemic myelopathy with a predilection for the cranial cervical spinal cord in older cats

2014 ◽  
Vol 16 (12) ◽  
pp. 1001-1006 ◽  
Author(s):  
Katherine M Simpson ◽  
Luisa De Risio ◽  
Anita Theobald ◽  
Laurent Garosi ◽  
Mark Lowrie
Keyword(s):  
Cervical Spinal Cord ◽  
Clinical Signs ◽  
Neurological Status ◽  
Acute Onset ◽  
Disease Course ◽  
Single Event ◽  
Long Term Follow Up ◽  
Time Of Presentation

All previous studies on feline ischaemic myelopathy (IM) have reported an acute onset of a single event with no recurrence of clinical signs. This study aimed to evaluate clinical and long-term follow-up data in cats presumptively diagnosed with cervical IM in the territory of the ventral spinal artery (VSA). Eight cats (four females and four males) were included with a mean age of 14 years and 2 months. Neurological status at the time of presentation ranged from ambulatory tetraparesis to tetraplegia with nociception present. Six cats had marked cervical ventroflexion. All eight cats were diagnosed with one or more concurrent medical conditions, including chronic kidney disease (n = 2), hypertrophic cardiomyopathy (n = 2) and hypertension (n = 6). Median time to ambulation was 5.7 days (range 2–14 days). Long-term follow-up ranged from 7 months to 3 years and 3 months (median 1 year and 2 months). Five cats had no reported recurrence of clinical signs and 3/8 had a chronic relapsing disease course. One cat had an acute recurrence of clinical signs 4 months after the first event and was euthanased. Two cats had acute onsets of suspected intracranial infarctions, one of which had further suspected intracranial infarcts every 3 months and was euthanased after one of these. This study highlights the importance of performing ancillary diagnostic tests in older cats presenting with IM, particularly when VSA embolisation is suspected.

scholarly journals Immune-mediated monofocal motor neuropathy: Report of two cases with long-term follow up and review of six published cases

2014 ◽  
Vol 2 (3) ◽  
pp. 76-81
Author(s):  
Bamidele O Adeyemo ◽  
James Andriotakis ◽  
Michael Dreyer ◽  
Pantelis P Pavlakis ◽  
Peter Siao
Keyword(s):  
Motor Neuropathy ◽  
Immune Mediated ◽  
Long Term Follow Up
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