Maxillo-mandibular osteoradionecrosis following C-ion radiotherapy: Clinical notes and review of literature

Osteoradionecrosis (ORN) is one of the most feared complications after head and neck radiotherapy. Among head and neck sites, the mandible is the most commonly involved bone. Heavy ion radiotherapy delivers high-dose distribution focused to the target while simultaneously sparing of the adjacent organs but there are anyway some reported cases of ORN. Cases in literature reported well-known risk factors for its developing (e.g. tobacco and alcohol abuse, diabetes), but other are still debated (e.g. teeth extraction during radiotherapy). Prevention is mandatory but multimodal care may be required, tailoring all treatments on the patient needs. This study, after a brief revision of the literature, reports and a case of maxillo-mandibular ORN following carbon-ion (C-ion) radiotherapy and its treatment.

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The Importance and Clinical Implications of FLASH Ultra-High Dose-Rate Studies for Proton and Heavy Ion Radiotherapy

Radiation Research ◽

10.1667/rr15537.1 ◽

2019 ◽

Vol 193 (1) ◽

pp. 1 ◽

Cited By ~ 11

Author(s):

Nicholas W. Colangelo ◽

Edouard I. Azzam

Keyword(s):

Dose Rate ◽

Heavy Ion ◽

High Dose Rate ◽

Clinical Implications ◽

High Dose ◽

Heavy Ion Radiotherapy

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Acute xerostomia in head and neck radiotherapy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20190757 ◽

2019 ◽

Vol 5 (2) ◽

pp. 262

Author(s):

Dalya S. A. Al-Nuaimi ◽

Khudair J. Al-Rawaq ◽

Ali G. M. Noori ◽

Marwa A. N. Fattah

Keyword(s):

Head And Neck ◽

Salivary Glands ◽

Medical History ◽

Associated Factors ◽

High Dose ◽

Past Medical History ◽

Common Complaint ◽

The Mean ◽

Head And Neck Radiotherapy ◽

High Chance

Background: Xerostomia is a common complaint experienced with radiotherapy to the head and neck and it is caused by salivary glands dysfunction. Methods: Xerostomia is a common complaint experienced with radiotherapy to the head and neck and it is caused by salivary glands dysfunction. Results: The mean age was 51.69±13.7 years; 67% were men and 33% were women. Nasopharyngeal tumor and larynx cancer were the common tumors diagnosed (29% and 28% respectively), 78% of the tumors were squamous cell carcinoma and 53% of them in stage III. Most patients didn’t take chemotherapy during radiotherapy (90%), while 68% of them have previously received chemotherapy. The mean dose of radiotherapy used was 63.2±9.65 Gray. Post radiotherapy, the highest proportion diagnosed with xerostomia grade I (37%), while 21% of them were free of xerostomia. Female, negative past medical history, site, stage and dose of radiation were associated factors that increased prevalence of xerostomia. Conclusions: After radiotherapy, there is a high chance for developing xerostomia. Females, negative past medical history, advanced stage of tumor, high dose of radiation and site of tumor (oral, nasopharyngeal, and parotid) were significantly associated factors. Tumor site was a significant factor associated with the grade of xerostomia.

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The role of melatonin on acute thyroid damage induced by high dose rate X-ray in head and neck radiotherapy

Radiation Physics and Chemistry ◽

10.1016/j.radphyschem.2020.109206 ◽

2021 ◽

Vol 179 ◽

pp. 109206

Author(s):

Serhat Aras ◽

İhsan Oğuz Tanzer ◽

Ünal Can ◽

Engin Sümer ◽

Kürşad Nuri Baydili

Keyword(s):

Head And Neck ◽

Dose Rate ◽

High Dose Rate ◽

High Dose ◽

X Ray ◽

Head And Neck Radiotherapy

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Design Analysis and Experimental Study of Robotic Chair for Proton Heavy Ion Radiotherapy

Applied Bionics and Biomechanics ◽

10.1155/2019/6410941 ◽

2019 ◽

Vol 2019 ◽

pp. 1-15 ◽

Cited By ~ 1

Author(s):

Yongde Zhang ◽

Zhikang Yang ◽

Jingang Jiang ◽

Xuesong Dai ◽

Peiwang Qin ◽

...

Keyword(s):

Head And Neck ◽

Heavy Ion ◽

Positioning Error ◽

Adjustment Mechanism ◽

Workspace Analysis ◽

Positioning Device ◽

Novel Design ◽

Heavy Ion Radiotherapy ◽

Fixed Beam ◽

Posture Adjustment

Proton heavy ion radiotherapy is widely used and currently represents the most advanced radiotherapy technology. However, at present, proton heavy ion radiotherapy chairs in fixed beam radiotherapy rooms do not have a head and neck positioning function. This paper presents a novel design for a proton heavy ion radiotherapy chair with a head and neck positioning device. The design of the posture adjustment mechanism and the head and neck positioning device of the treatment chair is based on U-TRIZ theory and ergonomics, respectively. A positive kinematic analysis of the posture adjusting mechanism was carried out, as well as a workspace analysis of the head and neck positioning device. Finally, positioning error experiment and ergonomic evaluation were performed on a prototype of the head and neck positioning device. The proposed design of the treatment chair satisfies the requirements for posture adjustment and achieves the head and neck positioning function. The experimental results also provide a basis for further optimization of the design.

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