scholarly journals Effect of Health Insurance on Hepatitis C Sustained Virologic Response Rates to Sofosbuvir-Based Treatment Regimens in a South Florida Community Hospital

2019 ◽  
Vol 18 ◽  
pp. 232595821983559 ◽  
Author(s):  
Paula Eckardt ◽  
Jianli Niu ◽  
Angela Savage ◽  
Tara Griffin ◽  
Elizabeth Sherman
Keyword(s):  
Health Insurance ◽  
Hepatitis C ◽  
Sustained Virologic Response ◽  
Community Hospital ◽  
Virologic Response ◽  
South Florida ◽  
Uninsured Patients ◽  
Loss To Follow Up ◽  
Insured Patients

The high cost of direct-acting antiviral–based regimens raises concerns about the outcome of treatment in uninsured patients with chronic hepatitis C virus (HCV) infection. This study assessed the relationship between health insurance status and sustained virologic response (SVR) rates in a community hospital in South Florida. Sofosbuvir-based therapy was initiated in 82 patients, of which 73% were uninsured and 28 (34%) were HIV coinfection. The overall SVR rate for those tested was 98%. The SVR rates were similar between HCV mono- and HCV/HIV coinfected patients (96% versus 100%, P = .204). Uninsured patients, with access to patient assistance programs, had comparable SVR rates to insured patients (100% versus 95%, P = .131). However, there was a trend toward a higher rate of loss to follow-up in uninsured compared to insured patients (25% versus 9%, P = .116). Strategies specific to adherence to treatment for uninsured patients are needed to reduce rates of loss to follow-up.

scholarly journals Long-term follow-up of patients with chronic hepatitis C with sustained virologic response to interferon

2010 ◽  
Vol 14 (4) ◽  
pp. 330-334 ◽  
Author(s):  
Sandro da Costa Ferreira ◽  
Marcos de Vasconcelos Carneiro ◽  
Fernanda Fernandes Souza ◽  
Andreza Corrêa Teixeira ◽  
Marcia Guimarães Villanova ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Sustained Virologic Response ◽  
Virologic Response ◽  
Long Term Follow Up

Twelve-Week Posttreatment Follow-Up to Predict Sustained Virologic Response for Recurrent Hepatitis C Infection in Liver Recipients

2012 ◽  
Vol 93 (4) ◽  
pp. 450-453 ◽  
Author(s):  
Isabel Campos-Varela ◽  
Lluis Castells ◽  
Juan Ignacio Esteban ◽  
Marta Bes ◽  
Francisco Rodríguez-Frías ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Sustained Virologic Response ◽  
Virologic Response ◽  
Hepatitis C Infection ◽  
Recurrent Hepatitis ◽  
Recurrent Hepatitis C

Twelve weeks of follow-up is sufficient for the determination of sustained virologic response in patients treated with interferon α for chronic hepatitis C

2003 ◽  
Vol 39 (1) ◽  
pp. 106-111 ◽  
Author(s):  
Stefan Zeuzem ◽  
E.Jenny Heathcote ◽  
Mitchell L Shiffman ◽  
Teresa L Wright ◽  
Vincent G Bain ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Sustained Virologic Response ◽  
Virologic Response ◽  
Interferon Α

Efficacy of antiviral therapy for chronic hepatitis C in children

2021 ◽  
Vol 19 (1) ◽  
pp. 119-123
Author(s):  
O.V. Churbakova ◽  
◽  
D.V. Pechkurov ◽  
T.A. Zhilyakova ◽  
V.G. Akimkin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Sustained Virologic Response ◽  
Disease Onset ◽  
Virologic Response ◽  
New Drugs ◽  
Hcv Rna

Objective. To analyze the efficacy of antiviral therapy for chronic hepatitis C (HCV) in children. Patients and methods. This study included 58 children aged between 3 and 17 years who had never received antiviral therapy (AVT) before and were treated in the Pediatric Department for Infectious Diseases, N.A.Semashko City Clinical Hospital No 2 (Samara). The inclusion criteria were as follows: confirmed CHC diagnosis and follow-up for at least one year. We analyzed treatment outcomes during an 8-year period, as well as the dynamics of clinical and biochemical parameters in children with HCV depending on their response to AVT. Results. Sustained virologic response (SVR) was achieved in 19 out of 58 children (32.8%) after 24 weeks of therapy and 30 out of 58 children (51.7%) after 48 weeks of therapy. In these children, viral genotypes were distributed as follows: 1b genotype in 19 participants (32.7%), 2a genotype in 4 participants (6.9%), and 3a genotype in 7 participants (12.1%). Twenty-eight patients (71.8%) remained HCV RNA positive, including 1 child with 2a genotype (2.6%), 3 children with 3a genotype (7.7%), and 24 children with 1b genotype (61.5%). Three years after treatment completion, 25 out of 58 patients (43.1%) had SVR. During 8 years of follow-up, 17 out of 30 children (56.7%) maintained SVR. Conclusion. Five out of 58 study participants (8.6%) developed F1–F2 liber fibrosis (METAVIR scale) over 8 years of follow-up. Two out of 58 children with HCV (3,5%) were found to have liver cirrhosis 6.6 ± 1.15 years after the disease onset (minimum – 4 years; maximum – 8 years). New drugs and treatment regimens are needed to increase the SVR rate in children. Key words: children, outcomes, sustained virologic response, chronic hepatitis C

scholarly journals Long-term follow-up of patients with chronic hepatitis C with sustained virologic response to interferon

2010 ◽  
Vol 14 (4) ◽  
pp. 330-334 ◽  
Author(s):  
Sandro da Costa Ferreira ◽  
Marcos de Vasconcelos Carneiro ◽  
Fernanda Fernandes Souza ◽  
Andreza Corrêa Teixeira ◽  
Marcia Guimarães Villanova ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Sustained Virologic Response ◽  
Virologic Response ◽  
Long Term Follow Up
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