Applications of Biophysics in Early Drug Discovery

SLAS DISCOVERY Advancing Life Sciences ◽

10.1177/24725552211035123 ◽

2021 ◽

Vol 26 (8) ◽

pp. 945-946

Author(s):

Geoffrey A. Holdgate ◽

Christian Bergsdorf

Keyword(s):

Drug Discovery ◽

Download Full-text

High throughput P450 inhibition screens in early drug discovery

Drug Discovery Today ◽

10.1016/s1359-6446(05)03580-4 ◽

2005 ◽

Vol 10 (21) ◽

pp. 1443-1450 ◽

Author(s):

Gregor Zlokarnik ◽

Peter D.J. Grootenhuis ◽

John B. Watson

Keyword(s):

Drug Discovery ◽

High Throughput ◽

Download Full-text

Strategic applications of toxicogenomics in early drug discovery

Current Opinion in Pharmacology ◽

10.1016/j.coph.2008.07.011 ◽

2008 ◽

Vol 8 (5) ◽

pp. 654-660 ◽

Author(s):

T RYAN ◽

J STEVENS ◽

C THOMAS

Keyword(s):

Drug Discovery ◽

Download Full-text

Model-based Target Pharmacology Assessment (mTPA): An Approach Using PBPK/PD Modeling and Machine Learning to Design Medicinal Chemistry and DMPK Strategies in Early Drug Discovery

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02033 ◽

2021 ◽

Vol 64 (6) ◽

pp. 3185-3196

Author(s):

Emile P. Chen ◽

Robert W. Bondi ◽

Paul J. Michalski

Keyword(s):

Machine Learning ◽

Drug Discovery ◽

Medicinal Chemistry ◽

Model Based ◽

Download Full-text

Role of Bioinformatics in Early Drug Discovery: An Overview and Perspective

10.1002/9781119654803.ch3 ◽

2021 ◽

pp. 49-67

Author(s):

Shasank S. Swain ◽

Tahziba Hussain

Keyword(s):

Drug Discovery ◽

Download Full-text

Application of Quantitative Biomeasures in Early Drug Discovery

Translating Molecular Biomarkers into Clinical Assays - AAPS Advances in the Pharmaceutical Sciences Series ◽

10.1007/978-3-319-40793-7_4 ◽

2016 ◽

pp. 37-46

Author(s):

Scott T. Fountain ◽

Paolo Vicini

Keyword(s):

Drug Discovery ◽

Download Full-text

Physicochemical Proling in Early Drug Discovery: New Challenges at the Age of High-Throughput Screen and Combinatorial Chemistry

Chemistry and Molecular Aspects of Drug Design and Action ◽

10.1201/9781420008272-31 ◽

2008 ◽

pp. 325-334

Keyword(s):

Drug Discovery ◽

High Throughput ◽

Combinatorial Chemistry ◽

High Throughput Screen ◽

New Challenges ◽

Download Full-text

Target Immobilization and NMR Screening of Fragments in Early Drug Discovery

Current Topics in Medicinal Chemistry ◽

10.2174/156802609790102400 ◽

2009 ◽

Vol 9 (18) ◽

pp. 1736-1745 ◽

Author(s):

Gregg Siegal ◽

Johan Hollander

Keyword(s):

Drug Discovery ◽

Nmr Screening ◽

Download Full-text

Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery

Handbook of Analytical Separations - Separation Methods in Drug Synthesis and Purification ◽

10.1016/b978-0-444-64070-3.00013-8 ◽

2020 ◽

pp. 667-758

Author(s):

Klára L. Valkó

Keyword(s):

Drug Discovery ◽

Drug Distribution ◽

Download Full-text

Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases

Trends in Parasitology ◽

10.1016/j.pt.2019.05.004 ◽

2019 ◽

Vol 35 (7) ◽

pp. 559-570 ◽

Author(s):

Nathalie Aulner ◽

Anne Danckaert ◽

JongEun Ihm ◽

David Shum ◽

Spencer L. Shorte

Keyword(s):

Drug Discovery ◽

Infectious Diseases ◽

Phenotypic Screening ◽

Next Generation ◽

Download Full-text

Proposal of a Parameter for OATP1B1 Inhibition Screening at the Early Drug Discovery Stage

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2019.08.012 ◽

2019 ◽

Vol 108 (12) ◽

pp. 3898-3902 ◽

Author(s):

Hiroyuki Murata ◽

Soichiro Ito ◽

Hiroyuki Kusuhara ◽

Yukihiro Nomura ◽

Toshio Taniguchi

Keyword(s):

Drug Discovery ◽

Discovery Stage ◽

Download Full-text