scholarly journals Coronary Artery Calcification: From Cell to Stent—A Review

2021 ◽  
pp. 263246362110131
Author(s):  
Kartik Pandurang Jadhav ◽  
K. Narasa Raju Kavalipatu ◽  
Pramod Kumar Kuchulakanti ◽  
Rohith P. Reddy ◽  
Ravikanth Athuluri ◽  
...  

Coronary artery calcification (CAC) is a well-known entity, with a high incidence amounting to a third of the total coronary artery disease (CAD) patients. It is also associated with a high complication rate during percutaneous transluminal coronary angioplasty, such as stent nontrackability, stent nonapposition, and underexpansion. The recent technological advances have helped to perform percutaneous coronary intervention in the calcified coronaries with better results. The management of calcified lesion was mainly concentrated on interventional techniques, this article gives a comprehensive review of CAC pathophysiology, its morphology, various diagnostic modalities, newer diagnostic tools, upcoming medical therapies, and interventional techniques. Newer therapies which include vitamin K and myoinositol hexaphosphate, their role in pathogenesis of CAC, and its future role in preventing and treating CAC are covered in this article.

Interventional cardiology is concerned with a number of invasive diagnostic and interventional procedures including coronary angiography and percutaneous coronary intervention (PCI). Coronary angiography is a definitive test to diagnose the presence of absence of coronary artery disease, in addition to nonatherosclerotic causes of stable angina, such as coronary artery spasm. PCI is a term that collectively describes a group of procedures that aim to restore or improve blood flow to the myocardium following a period of ischaemia or injury and includes: percutaneous transluminal coronary angioplasty (PTCA), intracoronary stenting, coronary atherectomy, and thrombectomy devices. The aim of this chapter is to provide a description, indications, and pre- and postprocedure care related to common diagnostic and interventional cardiology procedures. Sheath removal and vascular closure devices are also discussed.


2018 ◽  
Vol 3 (1) ◽  
pp. 182-185
Author(s):  
Fuji Pratiwi

Coronary Artery Disease (CAD) merupakan kondisi dimana terjadi penumpukan plak pada arteri koroner yang menyebabkan arteri koroner menyempit. Kondisi ini biasanya disebabkan oleh terkumpulnya kolestrol sehingga membentuk plak pada dinding arteri dalam jangka waktu yang cukup lama yang disebut aterosklerosis. CAD dapat menyebabkan otot jantung melemah, dan menimbulkan komplikasi seperti gagal jantung dan gangguan irama jantung. Percutaneous Transluminal Coronary Angioplasty (PTCA) atau dikenal juga dengan sebutan Percutaneous Coronary Intervention (PCI) adalah tindakan minimal invasif dengan melakukan pelebaran dari pembuluh darah koroner yang menyempit dengan balon dan dilanjutkan dengan pemasangan stent (gorong-gorong) agar pembuluh darah tersebut tetap terbuka. Tindakan dilakukan dengan hanya insisi kulit (Percutaneous) yang kecil, kemudian dimasukkan kateter ke dalam pembuluh darah (Transluminal) sampai ke pembuluh koroner dan dilakukan tindakan intervensi dengan inflasi balon dan pemasangan stent (Coronary Angioplasty) agar melebarkan pembuluh darah koroner kembali. Penelitian ini merupakan studi deskriptif dari laporan kasus seorang pasien dengan usia 70 tahun, laki – laki dengan diagnosa pasien CAD. Pengambilan data angiografi dilakukan langsung dari ruang Kateterisasi Jantung Rumah Sakit. Berdasarkan hasil tindakan Percutaneous Coronary Intervantion (PCI) telah mampu membuka aliran darah yang mengalami penyempitan untuk dapat menyalurkan darah ke otot jantung. Aliran pembuluh darah diperlihatkan dari hasil Angiografi. Hasil gambaran Angiorgrafi menunjukan perbedaan perubahan penyempitan pada pembuluh darah arteri koroner pasca PCI. Kata Kunci : CAD, PTCA, PCI


1993 ◽  
Vol 2 (2) ◽  
pp. 171-176 ◽  
Author(s):  
MA McGrath ◽  
GI Peet ◽  
JG Franke ◽  
RR Mildenberger ◽  
JE Morch ◽  
...  

BACKGROUND: Medical treatment of the elderly is changing to include the aggressive management of coronary artery disease with percutaneous transluminal coronary angioplasty. OBJECTIVE: The purpose of this study was to review major hospital events of patients aged 70 years or more, who underwent a first percutaneous transluminal coronary angioplasty. METHODS: A retrospective medical record review was done of 246 consecutive patients of 70 years or more, from January 1985 to December 1988, at a tertiary care community hospital. Adverse events and the factors that influenced outcome were identified. RESULTS: Of 246 patients (age range, 70-85 years, mean = 73.6), 19 died, 4 had a cerebral vascular accident, 11 had a transfusion and 11 underwent coronary artery bypass grafting. Sixteen patients had acute vessel closure and 8 died. Twenty-five patients had one event and 21 patients had more than one. DISCUSSION: The event rate after percutaneous transluminal coronary angioplasty in the elderly is high. CONCLUSIONS: Knowledge of the factors that influence adverse events (diagnostic category, success of procedure, degree of coronary artery disease and age) will assist the critical care team to plan and implement appropriate care.


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