scholarly journals Mother-to-offspring transmission of human T cell leukemia virus type I in rabbits

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1255-1258 ◽  
Author(s):  
Y Uemura ◽  
S Kotani ◽  
S Yoshimoto ◽  
M Fujishita ◽  
M Yamashita ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Lines ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

Abstract We studied the mode of natural transmission of human T-cell leukemia virus type I (HTLV-I) in rabbits. Four virus-infected rabbits (2 males and 2 females) were individually mated with 4 noninfected rabbits. Two virus-infected females mated with noninfected males gave birth to 7 offspring, and 2 noninfected females mated with infected males delivered 5 offspring. Four of the seven offspring born to the virus- infected mothers seroconverted for HTLV-I when aged 6 to 13 weeks with antibody titers of 1:40 to 1:160. None of the five offspring born to the noninfected mothers became seropositive during the observation period of 6 months, however. Peripheral lymphocytes were cultured with T cell growth factor, and HTLV-I-carrying lymphoid cell lines were established from the four seroconverted rabbits. All four cell lines were of T cells positive for Ia antigens. In addition, none of five newborn rabbits killed immediately after birth to a virus-infected rabbit was infected with HTLV-I. These findings provide an experimental support for the milkborne transmission of HTLV-I from mother to child in humans and indicate that the virus is tropic for T cells in rabbits as well.

scholarly journals Mother-to-offspring transmission of human T cell leukemia virus type I in rabbits

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1255-1258
Author(s):  
Y Uemura ◽  
S Kotani ◽  
S Yoshimoto ◽  
M Fujishita ◽  
M Yamashita ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Lines ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

We studied the mode of natural transmission of human T-cell leukemia virus type I (HTLV-I) in rabbits. Four virus-infected rabbits (2 males and 2 females) were individually mated with 4 noninfected rabbits. Two virus-infected females mated with noninfected males gave birth to 7 offspring, and 2 noninfected females mated with infected males delivered 5 offspring. Four of the seven offspring born to the virus- infected mothers seroconverted for HTLV-I when aged 6 to 13 weeks with antibody titers of 1:40 to 1:160. None of the five offspring born to the noninfected mothers became seropositive during the observation period of 6 months, however. Peripheral lymphocytes were cultured with T cell growth factor, and HTLV-I-carrying lymphoid cell lines were established from the four seroconverted rabbits. All four cell lines were of T cells positive for Ia antigens. In addition, none of five newborn rabbits killed immediately after birth to a virus-infected rabbit was infected with HTLV-I. These findings provide an experimental support for the milkborne transmission of HTLV-I from mother to child in humans and indicate that the virus is tropic for T cells in rabbits as well.

scholarly journals Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40xprotein and bovine papilloma virus encoded E2 protein

1988 ◽  
Vol 16 (14) ◽  
pp. 6547-6566 ◽  
Author(s):  
Shoichiro Miyatake ◽  
Motoharu Seiki ◽  
Rene DeWaal Malefijt ◽  
Toshio Heike ◽  
Jun-ichi Fujisawa ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Papilloma Virus ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells

2001 ◽  
Vol 31 (9) ◽  
pp. 2623-2632 ◽  
Author(s):  
Min Li-Weber ◽  
Marco Giaisi ◽  
Katerina Chlichlia ◽  
Khashayarsha Khazaie ◽  
Peter H. Krammer
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus

Augmentation of the Activity of an Immunotoxin, Anti-Tac(Fv)-PE40KDEL, in T Cell Lines Infected with Human T Cell Leukemia Virus Type-I

2002 ◽  
Vol 43 (4) ◽  
pp. 885-888 ◽  
Author(s):  
Nobuhito Ohno ◽  
Robert J. Kreitman ◽  
Takeshi Saito ◽  
Izumi Masamoto ◽  
Kimiharu Uozumi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
T Cell Lines

Human T-cell leukemia virus type-I-infected T-cell lines scarcely produce p56lck, whether or not they expresslck MRNA

1990 ◽  
Vol 46 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Nobuhira Oh-hori ◽  
Yasuhiro Koga ◽  
Hiroki Yoshida ◽  
Minoru Morita ◽  
Genki Kimura ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
T Cell Lines

scholarly journals Human T-cell leukemia virus type-I Tax induces the expression of CD83 on T cells

Retrovirology ◽  
2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuetsu Tanaka ◽  
Mariko Mizuguchi ◽  
Yoshiaki Takahashi ◽  
Hideki Fujii ◽  
Reiko Tanaka ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus
Sign in / Sign up

Export Citation Format

Share Document