Positron emission tomographic measurement of bone marrow blood flow to the pelvis and lumbar vertebrae in young normal adults [published erratum appears in Blood 1994 Nov 15;84(10):3602]

Abstract Ten young normal adults had pelvic and lumbar vertebral body bone marrow blood flow examined using [15O]water and positron emission tomography (PET) in a study designed to assess the feasibility and reproducibility of the PET technique for measuring marrow blood flow to various marrow regions. The procedure was well tolerated. Repeated blood flow measurements obtained from two consecutive [15O]water exams on each individual subject were highly reproducible. In addition, there was minimal variation in marrow blood flow from individual to individual and no gender differences were noted. In contrast, mean+/-SD bone marrow blood flows (expressed as milliliters per minute per 100 g) at selected anatomical sites were significantly different and were as follows: lower lumbar vertebral bodies, 17.6+/-3.1; most posterior and superior pelvis (conventional site of percutaneous bone marrow biopsy), 14.3+/-3.1; and total superior pelvis, 11.1+/-2.0. We conclude that PET is a relatively noninvasive, simple, and reproducible technique for measuring bone marrow blood flow. Marrow blood flow is consistent between normal young subjects, but varies significantly between different anatomic regions of the marrow.

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Positron emission tomographic measurement of bone marrow blood flow to the pelvis and lumbar vertebrae in young normal adults [published erratum appears in Blood 1994 Nov 15;84(10):3602]

Blood ◽

10.1182/blood.v83.4.958.bloodjournal834958 ◽

1994 ◽

Vol 83 (4) ◽

pp. 958-963

Author(s):

D Kahn ◽

GJ Weiner ◽

S Ben-Haim ◽

LL Ponto ◽

MT Madsen ◽

...

Keyword(s):

Bone Marrow ◽

Blood Flow ◽

Lumbar Vertebrae ◽

Individual Subject ◽

Flow Measurements ◽

Lumbar Vertebral Body ◽

Positron Emission ◽

Blood Flow Measurements ◽

Normal Adults ◽

Bone Marrow Blood

Ten young normal adults had pelvic and lumbar vertebral body bone marrow blood flow examined using [15O]water and positron emission tomography (PET) in a study designed to assess the feasibility and reproducibility of the PET technique for measuring marrow blood flow to various marrow regions. The procedure was well tolerated. Repeated blood flow measurements obtained from two consecutive [15O]water exams on each individual subject were highly reproducible. In addition, there was minimal variation in marrow blood flow from individual to individual and no gender differences were noted. In contrast, mean+/-SD bone marrow blood flows (expressed as milliliters per minute per 100 g) at selected anatomical sites were significantly different and were as follows: lower lumbar vertebral bodies, 17.6+/-3.1; most posterior and superior pelvis (conventional site of percutaneous bone marrow biopsy), 14.3+/-3.1; and total superior pelvis, 11.1+/-2.0. We conclude that PET is a relatively noninvasive, simple, and reproducible technique for measuring bone marrow blood flow. Marrow blood flow is consistent between normal young subjects, but varies significantly between different anatomic regions of the marrow.

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Cerebral Blood Flow Measurements by Magnetic Resonance Imaging Bolus Tracking: Comparison with [15O]H2O Positron Emission Tomography in Humans

Journal of Cerebral Blood Flow & Metabolism ◽

10.1097/00004647-199809000-00002 ◽

1998 ◽

Vol 18 (9) ◽

pp. 935-940 ◽

Cited By ~ 168

Author(s):

Leif Østergaard ◽

Peter Johannsen ◽

Peter Høst-Poulsen ◽

Peter Vestergaard-Poulsen ◽

Helle Asboe ◽

...

Keyword(s):

Positron Emission Tomography ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Magnetic Resonance ◽

Normal Subjects ◽

Emission Tomography ◽

Flow Measurements ◽

Bolus Tracking ◽

Positron Emission ◽

Blood Flow Measurements

In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using magnetic resonance (MR) bolus tracking was compared with [15O]H2O positron emission tomography (PET). The method yielded parametric CBF images with tissue contrast in good agreement with parametric PET CBF images. Introducing a common conversion factor, MR CBF values could be converted into absolute flow rates, allowing comparison of CBF values among normal subjects.

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Effects of neuropeptides and vasoactive substances on microcirculation of the callus after tibial osteotomy in rabbits

Acta Veterinaria Hungarica ◽

10.1556/avet.57.2009.3.9 ◽

2009 ◽

Vol 57 (3) ◽

pp. 427-439

Author(s):

Zsolt Vendégh ◽

András Melly ◽

Balázs Tóth ◽

Konrad Wolf ◽

Tamás Farkas ◽

...

Keyword(s):

Bone Marrow ◽

Blood Flow ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Perfusion Pressure ◽

Tibial Osteotomy ◽

Peripheral Vascular ◽

Flow Measurements ◽

Vasoactive Substances ◽

Blood Flow Measurements

Previous studies have demonstrated a dynamic ingrowth of vessels into the developing callus. In this study, maturation and development of the regulation of microcirculation were followed in the callus of rabbits. In the first series, the effects of vasoactive substances on blood flow velocity, perfusion pressure, duration of effects and peripheral vascular resistance of the bone marrow in the femur and tibia were compared. In the second series, the same parameters were measured in the femur and in the developing callus 10 and 15 days following gap osteotomy of the tibia. There were no significant differences between the microcirculatory reactions of the intact femur and tibia. Basal blood flow could be verified in the callus on the 10th postoperative day. No vascular reactions could be elicited. Basal blood flow velocity was higher on the 15th day, when compared to the measurements on the 10th day. The substances elicited statistically significant differences in flow velocity, resistance and 50% recovery time in the callus on the 15th day. Blood flow reactions of the ipsilateral femoral and tibial bone marrow are identical, thus the femur can serve as a reference site for blood flow measurements in the callus. Regulation and maturation of callus microcirculation develop rapidly between the 10th and 15th days.

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