Diagnostic model for occupational asthma induced by high-molecular-weight agents: A tertiary prevention tool

2021 ◽  
Author(s):  
Eva Suarthana ◽  
Olivier Vandenplas ◽  
Mahsa Taghiakbari ◽  
Jacques A. Pralong ◽  
Paramita Saha-Chaudhuri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Occupational Asthma ◽  
Tertiary Prevention ◽  
Diagnostic Model

scholarly journals Diagnostic model for sensitization in workers exposed to occupational high molecular weight allergens

2005 ◽  
Vol 48 (3) ◽  
pp. 168-174 ◽  
Author(s):  
Eva Suarthana ◽  
Yvonne Vergouwe ◽  
Mark Nieuwenhuijsen ◽  
Dick Heederik ◽  
Diederick E. Grobbee ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Diagnostic Model

scholarly journals Occupational bronchial asthma in the post-exposure period: possibilities to control

2008 ◽  
pp. 47-51
Author(s):  
P. N. Liubchenko ◽  
T. V. Stotskaya ◽  
T. G. Kabanova
Keyword(s):  
Primary Care ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Bronchial Asthma ◽  
Occupational Asthma ◽  
Exposure Period ◽  
Organic Dust ◽  
Steroid Dependence ◽  
Post Exposure ◽  
Care Facilities

Eighty-seven patients with occupational bronchial asthma in the post-exposure period (8.5 years in average) and 105 patients with non-occupational asthma were studied. In 64 % of cases, asthma was induced by high-molecular weight antigens of organic dust of various types. Severe course of the disease and steroid dependence were noted somewhat more often in patients with occupational professional asthma compared to non-occupational one (23 % among men and 30 % among women vs. 21 % and 20 %, respectively). Well-controlled occupational asthma was more often (9.60 % and 4.76 %, respectively) which could be explained by elimination of causative agent, annual examination and treatment in clinics of occupational pathology with further correction of the therapy in outpatient primary care facilities. The authors recommend applying criteria of asthma control to estimate the degree of the patient's disability.

Novel clinical scores for occupational asthma due to exposure to high-molecular-weight agents

2019 ◽  
Vol 76 (7) ◽  
pp. 495-501 ◽  
Author(s):  
Mahsa Taghiakbari ◽  
Jacques-André Pralong ◽  
Catherine Lemière ◽  
Gregory Moullec ◽  
Paramita Saha-Chaudhuri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Occupational Asthma ◽  
Internal Validity ◽  
P Value ◽  
Operating Characteristics ◽  
Logistic Regression Models ◽  
Tertiary Centre ◽  
Clinical Scores ◽  
Inhalation Challenge

ObjectiveSpecific inhalation challenge (SIC) as the reference diagnostic test for occupational asthma (OA) is not widely available worldwide. We aimed to develop non-SIC-based models for OA.MethodsOf 427 workers who were exposed to high-molecular-weight agents and referred to OA clinic at Montréal Sacré-Cœur Hospital between 1983 and 2016, we analysed 160 workers who completed non-specific bronchial hyper-responsiveness (NSBHR) tests and still worked 1 month before SIC. OA was defined as positive SIC. Logistic regression models were developed. The accuracy of the models was quantified using calibration and discrimination measures. Their internal validity was evaluated with bootstrapping procedures. The final models were translated into clinical scores and stratified into probability groups.ResultsThe final model, which included age ≤40 years, rhinoconjunctivitis, inhaled corticosteroid use, agent type, NSBHR, and work-specific sensitisation had a reasonable internal validity. The area under the receiver operating characteristics curve (AUC) was 0.91 (95% CI 0.86 to 0.95), statistically significantly higher than the combination of positive NSBHR and work-specific sensitisation (AUC=0.84). The top 70% of the clinical scores (ie, the high probability group) showed a significantly higher sensitivity (96.4%vs86.9%) and negative predictive value (93.6%vs84.1%) than the combination of positive NSBHR and work-specific sensitisation (p value <0.001).ConclusionsWe developed novel scores for OA induced by high-molecular-weight agents with excellent discrimination. It could be helpful for secondary-care physicians who have access to pulmonary function test and allergy testing in identifying subjects at a high risk of having OA and in deciding on appropriate referral to a tertiary centre.

Microtubule motors and other maps

1990 ◽  
Vol 48 (3) ◽  
pp. 1-1
Author(s):  
Richard B. Vallee
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Cytoplasmic Dynein ◽  
Organelle Transport ◽  
Structural Components ◽  
Microtubule Associated Proteins ◽  
Microtubule Motors ◽  
Associated Proteins ◽  
The Subject ◽  
Intracellular Motility

Microtubules are involved in a number of forms of intracellular motility, including mitosis and bidirectional organelle transport. Purified microtubules from brain and other sources contain tubulin and a diversity of microtubule associated proteins (MAPs). Some of the high molecular weight MAPs - MAP 1A, 1B, 2A, and 2B - are long, fibrous molecules that serve as structural components of the cytamatrix. Three MAPs have recently been identified that show microtubule activated ATPase activity and produce force in association with microtubules. These proteins - kinesin, cytoplasmic dynein, and dynamin - are referred to as cytoplasmic motors. The latter two will be the subject of this talk.Cytoplasmic dynein was first identified as one of the high molecular weight brain MAPs, MAP 1C. It was determined to be structurally equivalent to ciliary and flagellar dynein, and to produce force toward the minus ends of microtubules, opposite to kinesin.

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