A multicompartmemt lung model predicts pulmonary pharmacokinetics of inhaled liposomal treprostinil (L606) in healthy volunteer

2021 ◽  
Author(s):  
Pei Kan ◽  
Ko-Jie Chen
Keyword(s):  
Healthy Volunteer ◽  
Lung Model

Near Wall Turbulence Effects on Particle Transport and Deposition in Human Tracheobronchial Multi-Level Bifurcation Model

2015 ◽  
Author(s):  
Amir A. Mofakham ◽  
Lin Tian ◽  
Goodarz Ahmadi
Keyword(s):  
Boundary Conditions ◽  
Particle Deposition ◽  
Flow Simulation ◽  
Tracheobronchial Tree ◽  
Lung Model ◽  
Wall Turbulence ◽  
Nano Particles ◽  
Turbulent Regime ◽  
Computationally Efficient ◽  
Multi Level

Transport and deposition of micro and nano-particles in the upper tracheobronchial tree were analyzed using a multi-level asymmetric lung bifurcation model. The multi-level lung model is flexible and computationally efficient by fusing sequence of individual bifurcations with proper boundary conditions. Trachea and the first two generations of the tracheobronchial airway were included in the analysis. In these regions, the airflow is in turbulent regime due to the disturbances induced by the laryngeal jet. Anisotropic Reynolds stress transport turbulence model (RSTM) was used for mean the flow simulation, together with the enhanced two-layer model boundary conditions. Particular attention is given to evaluate the importance of the “quadratic variation of the turbulent fluctuations perpendicular to the wall” on particle deposition in the upper tracheobroncial airways.

HIGH FREQUENCY PERCUSSIVE VENTILATION CAN MIMIC AIRWAY PRESSURE RELEASE VENTILATION IN A TEST LUNG MODEL

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A38
Author(s):  
Faera L Byerly ◽  
Bruce A Cairns ◽  
Kathy A Short ◽  
John A Haithcock ◽  
Lynn Shapiro ◽  
...  
Keyword(s):  
High Frequency ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Lung Model ◽  
Test Lung ◽  
Pressure Release ◽  
Pressure Release Ventilation
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