Predictors of end-organ damage in patients with Obstructive Sleep Apnea according to the Baveno classification

Author(s):  
Mariana Serino ◽  
Catarina Cardoso ◽  
Ricardo José Cordeiro ◽  
Joana Ferra ◽  
Filipa Aguiar ◽  
...  
2015 ◽  
Vol 10 (3) ◽  
pp. 182-188 ◽  
Author(s):  
Radostina Vlaeva Cherneva ◽  
Ognian Borisov Georgiev ◽  
Daniela Stoichkova Petrova ◽  
Emil Ivanov Manov ◽  
Dinko Georgiev Valev ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Costas Thomopoulos ◽  
Helena Michalopoulou ◽  
Alexandros Kasiakogias ◽  
Anna Kefala ◽  
Thomas Makris

Enhanced target organ damage and cardiovascular morbidity represent common issues observed in both resistant hypertension and obstructive sleep apnea. Common pathophysiological features and risk factors justify their coexistence, especially in individuals with increased upper-body adiposity. Impaired sodium handling, sympathetic activation, accelerated arterial stiffening, and impaired cardiorenal hemodynamics contribute to drug-resistant hypertension development in obstructive sleep apnea. Effective CPAP therapy qualifies as an effective “add-on” to the underlying antihypertensive pharmacological therapy, and emerging evidence underlines the favorable effect of mineralocorticoid antagonists on both resistant hypertension and obstructive sleep apnea treatment.


2012 ◽  
Vol 18 (6) ◽  
pp. 514-521 ◽  
Author(s):  
N. E. Zvartau ◽  
L. S. Korostovtseva ◽  
I. V. Emelyanov ◽  
Yu. V. Sviryaev

The review discusses the new data about primary aldosteronism and the connection between increase of aldosterone level and resistance to antihypertensive treatment, including patients with obstructive sleep apnea. Also the main pathophysiological mechanisms underlying the progression of end organ damage and leading to resistance to antihypertensive treatment in patients with high aldosterone level are presented.


2018 ◽  
Vol 36 (6) ◽  
pp. 1351-1359 ◽  
Author(s):  
Paola Mattaliano ◽  
Carolina Lombardi ◽  
Davide Sangalli ◽  
Andrea Faini ◽  
Barbara Corrà ◽  
...  

Author(s):  
Cesare Cuspidi ◽  
Marijana Tadic ◽  
Elisa Gherbesi ◽  
Carla Sala ◽  
Guido Grassi

2012 ◽  
Vol 18 (3) ◽  
pp. 184-190 ◽  
Author(s):  
N. E. Zvartau ◽  
YU. V. Sviryaev ◽  
L. S. Korostovtseva ◽  
A. O. Konradi

The article reviews possible mechanisms responsible for drug resistance in hypertensive patients with obstructive sleep apnea. Data about more profound target organ damage, partly explained by activation of inflammation, endothelial dysfunction due to recurrent hypoxia episodes and by blood pressure pattern in apnea patients are presented. Stimulation of renin-angiotensin-aldosterone system has a negative impact on cardiovascular system and deteriorates sleep apnea severity.


2019 ◽  
Vol 4 (5) ◽  
pp. 878-892
Author(s):  
Joseph A. Napoli ◽  
Linda D. Vallino

Purpose The 2 most commonly used operations to treat velopharyngeal inadequacy (VPI) are superiorly based pharyngeal flap and sphincter pharyngoplasty, both of which may result in hyponasal speech and airway obstruction. The purpose of this article is to (a) describe the bilateral buccal flap revision palatoplasty (BBFRP) as an alternative technique to manage VPI while minimizing these risks and (b) conduct a systematic review of the evidence of BBFRP on speech and other clinical outcomes. A report comparing the speech of a child with hypernasality before and after BBFRP is presented. Method A review of databases was conducted for studies of buccal flaps to treat VPI. Using the principles of a systematic review, the articles were read, and data were abstracted for study characteristics that were developed a priori. With respect to the case report, speech and instrumental data from a child with repaired cleft lip and palate and hypernasal speech were collected and analyzed before and after surgery. Results Eight articles were included in the analysis. The results were positive, and the evidence is in favor of BBFRP in improving velopharyngeal function, while minimizing the risk of hyponasal speech and obstructive sleep apnea. Before surgery, the child's speech was characterized by moderate hypernasality, and after surgery, it was judged to be within normal limits. Conclusion Based on clinical experience and results from the systematic review, there is sufficient evidence that the buccal flap is effective in improving resonance and minimizing obstructive sleep apnea. We recommend BBFRP as another approach in selected patients to manage VPI. Supplemental Material https://doi.org/10.23641/asha.9919352


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