scholarly journals Plasma renin activity profile of patients with congenital adrenal hyperplasia in Semarang, Indonesia: a preliminary study

2013 ◽  
Vol 2013 (S1) ◽  
Author(s):  
Mahayu Dewi Ariani ◽  
Nani Maharani ◽  
Udin Bahrudin ◽  
Agustini Utari ◽  
Sultana MH Faradz
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenal Hyperplasia ◽  
Activity Profile ◽  
Preliminary Study

scholarly journals Association Between Plasma Renin Activity with Hypertension in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Enzyme Deficiency

2021 ◽  
Author(s):  
Siska Mayasari Lubis ◽  
Eka Lakshmi Hidayati ◽  
Frida Soesanti ◽  
Bambang Tridjaja AAP
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Cross Sectional Study ◽  
Renin Activity ◽  
Enzyme Deficiency ◽  
Activity Levels ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Salt Wasting

Abstract BackgroundHypertension is an uncommon manifestation of congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency (21-OHD CAH). Nevertheless, it is necessary to continuously be aware of hypertension incidence in 21-OHD CAH patients and its possible causes. Conflicting results regarding the role of PRA have been reported. This study aims to evaluate the association between plasma renin activity levels (PRA) with hypertension in 21-OHD CAH children. MethodsWe did an observational analytic study with a cross-sectional study design. The subjects were 21-OHD CAH children, aged >6 months to 18 years, selected by consecutive sampling and then compared between 21-OHD CAH with hypertension and non-hypertension groups. We gathered 40 subjects, 20 subjects in hypertension and 20 subjects in non-hypertension groups.ResultsThere were 16 from 27 (59.3%) and 4 from 13 subjects (30.8%) with hypertension in salt-wasting and simple virilizing type, respectively. There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt wasting patients (p=0,016). The risk of hypertension in salt wasting patients with low PRA levels was 1,09 times after controlling for sex, 17-OHP levels, and the last fludrocortisone dose. The last dose of hydrocortisone had a significant relationship with the incidence of hypertension in salt wasting patients. ConclusionsThis study concludes that hypertension in 21-OHD CAH patients during the study period was 32%. The risk of hypertension in salt wasting patients with low PRA levels was 1.09 times after being controlled for sex, 17 OHP level, and the last dose of fludrocortisone.

PLASMA RENIN ACTIVITY AND ALDOSTERONE SECRETION IN CONGENITAL ADRENAL HYPERPLASIA

1967 ◽  
Vol 56 (1_Suppl) ◽  
pp. S84 ◽  
Author(s):  
A. F. Muller ◽  
C. Godard ◽  
A. M. Riondel ◽  
R. Veyrat ◽  
A. Mégevand
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenal Hyperplasia ◽  
Aldosterone Secretion

scholarly journals Plasma renin activity in the management of congenital adrenal hyperplasia.

1984 ◽  
Vol 59 (4) ◽  
pp. 360-365 ◽  
Author(s):  
K D Griffiths ◽  
J M Anderson ◽  
B T Rudd ◽  
N K Virdi ◽  
G Holder ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenal Hyperplasia

scholarly journals Plasma Renin Activity and the Response to Sodium Depletion in Salt-Losing Congenital Adrenal Hyperplasia

1982 ◽  
Vol 16 (2) ◽  
pp. 118-122
Author(s):  
Bruce S Keenan ◽  
John H Holcombe ◽  
Donnie P Wilson ◽  
Rebecca T Kirkland ◽  
Elaine Potts ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Plasma Renin ◽  
Renin Activity ◽  
Sodium Depletion ◽  
Adrenal Hyperplasia

PLASMA RENIN ACTIVITY AND ALDOSTERONE SECRETION IN CONGENITAL ADRENAL HYPERPLASIA

PEDIATRICS ◽  
1968 ◽  
Vol 41 (5) ◽  
pp. 883-896
Author(s):  
Claude Godard ◽  
Anne M. Riondel ◽  
Robert Veyrat ◽  
Albert Mégevand ◽  
Alex F. Muller
Keyword(s):  
Plasma Renin Activity ◽  
Congenital Adrenal Hyperplasia ◽  
Salt Intake ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Renin Activity ◽  
Adrenal Hyperplasia ◽  
Aldosterone Secretion ◽  
Normal Children ◽  
Salt Restriction

Experiments were undertaken to study simultaneously plasma renin activity (PRA) and aldosterone secretion (Aldo-SR) in seven patients with congenital adrenal hyperplasia (CAH), aged 5 months to 12 years, and four normal subjects. Control values of renin on a liberal salt intake in 28 children were 19 ± 16 ng/l/minute, which is considerably higher than in adults (9 ± 7.6 ng/l/minute). Of the seven patients, four had PRA levels between 26 and 39 ng/l/minute. The other three had levels of 115, 249, and 1,250 ng/l/minute on a liberal salt intake. Aldo-SR was between 131 and 264 µg/24 hours in four subjects and was low in two (12 and 37 µg/24 hours). Salt restriction increased PRA 3.5 to five times in four patients, compared with two times in four normal subjects. Despite the high renin values, Aldo-SR increased at the utmost threefold, compared with a four- to eightfold increase in the normal children. That discrepancy between PRA and Aldo-SR points to a defect in aldosterone synthesis in all forms of CAH. PRA and Aldo-SR were both lowered by steroid therapy.

PLASMA RENIN ACTIVITY IN CONGENITAL VIRILIZING ADRENAL HYPERPLASIA

PEDIATRICS ◽  
1968 ◽  
Vol 41 (5) ◽  
pp. 897-904
Author(s):  
Masashi Imai ◽  
Yoshio Igarashi ◽  
Hirofumi Sokabe
Keyword(s):  
Sodium Chloride ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Adrenal Hyperplasia ◽  
Peripheral Plasma

Peripheral plasma renin activity was markedly elevated in two cases of the salt-losing form of congenital virilizing adrenal hyperplasia. The renin activity was reduced after treatment with deoxycorticosterone and sodium chloride. In the hypertensive form of the plasma renin activity was suppressed.

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