scholarly journals Acute hepatitis C in persons infected with the human immunodeficiency virus (HIV): the 'real-life setting' proves the concept

2010 ◽  
Vol 13 (Suppl 4) ◽  
pp. P202
Author(s):  
P Ingiliz ◽  
MJ Obermeier ◽  
L Weitner ◽  
C Cordes ◽  
A Moll ◽  
...  





2010 ◽  
Vol 30 (8) ◽  
pp. 1169-1172 ◽  
Author(s):  
Martin Vogel ◽  
Thijs Van De Laar ◽  
Bernd Kupfer ◽  
Hans-Jürgen Stellbrink ◽  
Tim Kümmerle ◽  
...  




2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Romain Ragonnet ◽  
Sylvie Deuffic-Burban ◽  
Christoph Boesecke ◽  
Marguerite Guiguet ◽  
Karine Lacombe ◽  
...  

Abstract Background Hepatitis C virus (HCV) infection is often asymptomatic, and the date of infection is almost impossible to determine. Furthermore, spontaneous clearance (SC) may occur, but little is known about its time of occurrence. Methods Data on human immunodeficiency virus (HIV)-HCV coinfected individuals were used to inform a stochastic simulation model of HCV viral load kinetics, alanine aminotransferase (ALT), and HCV antibodies during acute hepatitis C. The dates of diagnosis and potential SC were estimated through a Bayesian approach. Hepatitis C virus diagnosis was assumed to be based on an elevated ALT level detected during a control visit for HIV-infected individuals, which occurred every 3 months (scenario A) or every 6 months (scenario B). Results We found that HCV diagnosis occurred after a median of 115 days and 170 days of infection in scenarios A and B, respectively. Among spontaneous clearers, SC occurred after a median time of 184 days after infection. Seven percent (scenario B) to 10% (scenario A) of SCs appeared more than 6 months after diagnosis, and 3% (both scenarios) of SCs appeared more than 1 year after diagnosis. Conclusions Acute hepatitis C diagnosis occurs late in HIV-HCV coinfected individuals. Screening for HCV in HIV-infected individuals should be performed frequently to reduce delays. Our findings about late occurrence of SC support “wait and see” strategies for treatment initiation from an individual basis. However, early treatment initiation may reduce HCV transmission.



Hepatology ◽  
2010 ◽  
Vol 52 (6) ◽  
pp. 1915-1921 ◽  
Author(s):  
Lionel Piroth ◽  
Christine Larsen ◽  
Christine Binquet ◽  
Laurent Alric ◽  
Isabelle Auperin ◽  
...  




2008 ◽  
Vol 48 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Patrice Cacoub ◽  
Philippe Halfon ◽  
Eric Rosenthal ◽  
Gilles Pialoux ◽  
Yves Benhamou ◽  
...  


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