Differential diagnosis of systemic inflammatory response syndrome versus sepsis based on a multiplex quantitative PCR assay

Infections are quite common, especially in long-term hospitalized patients. Eearly differential diagnosis of severe bacterial and viral infections in patients in severe or critical condition is particularly important. Procalcitonin is a good and, above all, early marker of sepsis and generalized inflammatory states. 85% sensitivity and 91% specificity of this study were shown in the differentiation patients with systemic inflammatory response syndrome noninfectious and sepsis defined as a systemic inflammatory response syndrome induced by infection. The usage of procalcitonin assays in clinical algorithms may accelerate the diagnosis of infectious conditions, reduce the abuse of antibiotics and optimize therapy with these drugs. Therefore, the determination of procalcitonin concentration is increasingly used in clinical practice.

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Procalcitonin for the differential diagnosis of infectious and non-infectious systemic inflammatory response syndrome after cardiac surgery

Journal of Intensive Care ◽

10.1186/2052-0492-2-35 ◽

2014 ◽

Vol 2 (1) ◽

pp. 35 ◽

Cited By ~ 6

Author(s):

Dong Zhao ◽

Jianxin Zhou ◽

Go Haraguchi ◽

Hirokuni Arai ◽

Chieko Mitaka

Keyword(s):

Differential Diagnosis ◽

Cardiac Surgery ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Systemic Inflammatory Response

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Evaluation of usefulness of myeloperoxidase index (MPXI) for differential diagnosis of systemic inflammatory response syndrome (SIRS) in the emergency department

Emergency Medicine Journal ◽

10.1136/emermed-2013-203137 ◽

2014 ◽

Vol 32 (4) ◽

pp. 304-307 ◽

Cited By ~ 3

Author(s):

Yong Sung Cha ◽

Jeong Min Yoon ◽

Woo Jin Jung ◽

Yong Won Kim ◽

Tae Hoon Kim ◽

...

Keyword(s):

Emergency Department ◽

Differential Diagnosis ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Systemic Inflammatory Response

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Potential Lipid Signatures for Diagnosis and Prognosis of Sepsis and Systemic Inflammatory Response Syndrome

Metabolites ◽

10.3390/metabo10090359 ◽

2020 ◽

Vol 10 (9) ◽

pp. 359

Author(s):

Giovana Colozza Mecatti ◽

Salvador Sánchez-Vinces ◽

Anna Maria A. P. Fernandes ◽

Marcia C. F. Messias ◽

Gabrielle K. D. de Santis ◽

...

Keyword(s):

Differential Diagnosis ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Systemic Inflammatory Response ◽

Negative Ion ◽

Multivariate Statistical ◽

Diagnosis And Prognosis ◽

Negative Ion Mode ◽

Potential Tool

Systemic inflammatory response syndrome (SIRS) and sepsis are two conditions which are difficult to differentiate clinically and which are strongly impacted for prompt intervention. This study identified potential lipid signatures that are able to differentiate SIRS from sepsis and to predict prognosis. Forty-two patients, including 21 patients with sepsis and 21 patients with SIRS, were involved in the study. Liquid chromatography coupled to mass spectrometry and multivariate statistical methods were used to determine lipids present in patient plasma. The obtained lipid signatures revealed 355 features for the negative ion mode and 297 for the positive ion mode, which were relevant for differential diagnosis of sepsis and SIRS. These lipids were also tested as prognosis predictors. Lastly, L-octanoylcarnitine was found to be the most promising lipid signature for both the diagnosis and prognosis of critically ill patients, with accuracies of 75% for both purposes. In short, we presented the determination of lipid signatures as a potential tool for differential diagnosis of sepsis and SIRS and prognosis of these patients.

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