Procalcitonin as a diagnostic marker of infections and inflammation

2018 ◽  
Vol 54 (3) ◽  
pp. 179-184
Author(s):  
Weronika Kolasińska ◽  
Agnieszka Jankowska-Kulawy
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Viral Infections ◽  
Diagnostic Marker ◽  
Systemic Inflammatory Response ◽  
Clinical Algorithms

Infections are quite common, especially in long-term hospitalized patients. Eearly differential diagnosis of severe bacterial and viral infections in patients in severe or critical condition is particularly important. Procalcitonin is a good and, above all, early marker of sepsis and generalized inflammatory states. 85% sensitivity and 91% specificity of this study were shown in the differentiation patients with systemic inflammatory response syndrome noninfectious and sepsis defined as a systemic inflammatory response syndrome induced by infection. The usage of procalcitonin assays in clinical algorithms may accelerate the diagnosis of infectious conditions, reduce the abuse of antibiotics and optimize therapy with these drugs. Therefore, the determination of procalcitonin concentration is increasingly used in clinical practice.

scholarly journals Potential Lipid Signatures for Diagnosis and Prognosis of Sepsis and Systemic Inflammatory Response Syndrome

Metabolites ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 359
Author(s):  
Giovana Colozza Mecatti ◽  
Salvador Sánchez-Vinces ◽  
Anna Maria A. P. Fernandes ◽  
Marcia C. F. Messias ◽  
Gabrielle K. D. de Santis ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Systemic Inflammatory Response ◽  
Negative Ion ◽  
Multivariate Statistical ◽  
Diagnosis And Prognosis ◽  
Negative Ion Mode ◽  
Potential Tool

Systemic inflammatory response syndrome (SIRS) and sepsis are two conditions which are difficult to differentiate clinically and which are strongly impacted for prompt intervention. This study identified potential lipid signatures that are able to differentiate SIRS from sepsis and to predict prognosis. Forty-two patients, including 21 patients with sepsis and 21 patients with SIRS, were involved in the study. Liquid chromatography coupled to mass spectrometry and multivariate statistical methods were used to determine lipids present in patient plasma. The obtained lipid signatures revealed 355 features for the negative ion mode and 297 for the positive ion mode, which were relevant for differential diagnosis of sepsis and SIRS. These lipids were also tested as prognosis predictors. Lastly, L-octanoylcarnitine was found to be the most promising lipid signature for both the diagnosis and prognosis of critically ill patients, with accuracies of 75% for both purposes. In short, we presented the determination of lipid signatures as a potential tool for differential diagnosis of sepsis and SIRS and prognosis of these patients.

scholarly journals Systemic inflammatory response syndrome and long-term outcome after intracerebral hemorrhage

2019 ◽  
Vol 6 (5) ◽  
pp. e588 ◽  
Author(s):  
Manuel Hagen ◽  
Jochen A. Sembill ◽  
Maximilian I. Sprügel ◽  
Stefan T. Gerner ◽  
Dominik Madžar ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Intracerebral Hemorrhage ◽  
Functional Outcome ◽  
Liver Dysfunction ◽  
Systemic Inflammatory Response ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Hematoma Enlargement

ObjectiveTo investigate whether the systemic inflammatory response syndrome (SIRS) without infection as surrogate of a systemic immune response is associated with poor long-term functional outcome in patients with spontaneous intracerebral hemorrhage (ICH).MethodsWe analyzed consecutive patients with spontaneous ICH from our prospective cohort study (2018–2015). SIRS was defined according to standard criteria: i.e., 2 or more of the following parameters during hospitalization: body temperature <36°C or >38°C, respiratory rate >20 per minute, heart rate >90 per minute, or white blood cell count <4,000/μL or >12,000/μL in the absence of infection. The primary outcome consisted of the modified Rankin Scale (mRS) at 3 and 12 months investigated by adjusted ordinal shift analyses. Bias and confounding were addressed by propensity score matching and multivariable regression models.ResultsOf 780 patients with ICH, 21.8% (n = 170) developed SIRS during hospitalization. Patients with SIRS showed more severe ICH compared with those without; i.e., larger ICH volumes (18.3 cm3, interquartile range [IQR 4.6–47.2 cm3] vs 7.4 cm3, IQR [2.4–18.6 cm3]; p < 0.01), increased intraventricular hemorrhage (57.6%, n = 98/170 vs 24.8%, n = 79/319; p < 0.01), and poorer neurologic admission status (NIH Stroke Scale score 16, IQR [7–30] vs 6, IQR [3–12]; p < 0.01). ICH severity-adjusted analyses revealed an independent association of SIRS with poorer functional outcome after 3 (OR 1.80, 95% CI [1.08–3.00]; p = 0.025) and 12 months (OR 1.76, 95% CI [1.04–2.96]; p = 0.034). Increased ICH volumes on follow-up imaging (OR 1.38, 95% CI [1.01–1.89]; p = 0.05) and previous liver dysfunction (OR 3.01, 95% CI [1.03–10.19]; p = 0.04) were associated with SIRS.ConclusionsIn patients with ICH, we identified SIRS to be predictive of poorer long-term functional outcome over the entire range of mRS estimates. Clinically relevant associations with SIRS were documented for previous liver dysfunction and hematoma enlargement.

SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE IN PATIENTS WITH ACUTE RESPIRATORY VIRAL INFECTIONS OF CHILDREN

2017 ◽  
Vol 96 (4) ◽  
pp. 22-27 ◽  
Author(s):  
I. V. Babachenko ◽  
◽  
L. A. Alekseeva ◽  
O. M. Ibragimova ◽  
Т. V. Bessonova ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Viral Infections ◽  
Systemic Inflammatory Response ◽  
Respiratory Viral Infections
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