The impact of indocyanine green (ICG) angiography in multiple diagnostic imaging for the management of exudative age-related macular degeneration (ARMD): a single blind prospective randomised controlled trial of fluorescein angiography vs FA & ICG

2013 ◽  
Author(s):  
Sergio Pagliarini
Keyword(s):  
Randomised Controlled Trial ◽  
Diagnostic Imaging ◽  
Indocyanine Green ◽  
Controlled Trial ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Icg Angiography ◽  
Randomised Controlled ◽  
The Impact ◽  
Single Blind

scholarly journals Dietary intervention in patients with age-related macular degeneration: protocol for a randomised controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e024774 ◽  
Author(s):  
Diana Tang ◽  
Paul Mitchell ◽  
Victoria Flood ◽  
Annette Kifley ◽  
Alison Hayes ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Macular Degeneration ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
Empirical Evaluation ◽  
Age Related Macular Degeneration ◽  
Dietary Recommendations ◽  
Phone Calls ◽  
Age Related ◽  
Randomised Controlled

IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness. After smoking, nutrition is the key modifiable factor in reducing AMD incidence and progression, and no other preventative treatments are currently available. At present, there is an evidence–practice gap of dietary recommendations made by eye care practitioners and those actually practised by patients with AMD. To address this gap, a telephone-delivered dietary intervention tailored to patients with AMD will be piloted. The study aims to improve dietary intake and behaviours in patients with AMD. This type of nutrition-focused healthcare is currently not considered in the long-term management of AMD and represents the first empirical evaluation of a telephone-supported application encouraging adherence to dietary recommendations for AMD.Methods and analysis140 participants with AMD will be recruited for this randomised controlled trial. Those lacking English fluency; unwilling to engage in the intervention or provide informed consent were excluded. Following the completion of the baseline questionnaire, participants will be randomised into one of two arms: intervention or wait-list control (70 each in the intervention and control groups). Intervention participants will receive a detailed mail-delivered workbook containing information on healthy eating behaviours that promote optimal macular health, as well as scheduled phone calls over 4 months from an accredited practising dietitian. Descriptive statistics and multivariate stepwise linear regressions analyses will be used to summarise and determine the changes in dietary intakes, respectively. Economic analysis will be conducted to determine intervention feasibility and possibility of a large-scale rollout.Ethics and disseminationThe study was approved by the University of Sydney Human Research Ethics Committee (HREC) (Reference: HREC 2018/219). Study findings will be disseminated via presentations at national/international conferences and peer-reviewed journal articles.Trial registration numberACTRN12618000527268; Pre-results.

scholarly journals Implementing a multi-modal support service model for the family caregivers of persons with age-related macular degeneration: a study protocol for a randomised controlled trial

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e018204 ◽  
Author(s):  
Bamini Gopinath ◽  
Ashley Craig ◽  
Annette Kifley ◽  
Gerald Liew ◽  
Jaye Bloffwitch ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Family Caregivers ◽  
Controlled Trial ◽  
Behavioural Therapy ◽  
Support Service ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Cognitive Behavioural ◽  
Registration Number ◽  
Randomised Controlled

IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness and low vision among older adults. Previous research shows a high prevalence of distress and disruption to the lifestyle of family caregivers of persons with late AMD. This supports existing evidence that caregivers are ‘hidden patients’ at risk of poor health outcomes. There is ample scope for improving the support available to caregivers, and further research should be undertaken into developing services that are tailored to the requirements of family caregivers of persons with AMD. This study aims to implement and evaluate an innovative, multi-modal support service programme that aims to empower family caregivers by improving their coping strategies, enhancing hopeful feelings such as self-efficacy and helping them make the most of available sources of social and financial support.Methods and analysisA randomised controlled trial consisting of 360 caregiver–patient pairs (180 in each of the intervention and wait-list control groups). The intervention group will receive the following: (1) mail-delivered cognitive behavioural therapy designed to improve psychological adjustment and adaptive coping skills; (2) telephone-delivered group counselling sessions allowing caregivers to explore the impacts of caring and share their experiences; and (3) education on available community services/resources, financial benefits and respite services. The cognitive behavioural therapy embedded in this programme is the best evaluated and widely used psychosocial intervention. The primary outcome is a reduction in caregiver burden. Secondary outcomes include improvements in caregiver mental well-being, quality of life, fatigue and self-efficacy. Economic analysis will inform whether this intervention is cost-effective and if it is feasible to roll out this service on a larger scale.Ethics and disseminationThe study was approved by the University of Sydney human research ethics committee. Study findings will be disseminated via presentations at national/international conferences and peer-reviewed journal articles.Trial registration numberThe trial registration number is ACTRN12616001461482; pre-results.

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