HTA Study of Antidepressants for Depression in Dementia: A definitive multi-centre pragmatic randomised controlled double-blind trial of the clinical and cost effectiveness of mirtazapine and sertraline versus placebo for the treatment of depression in dementia presenting in secondary care

2012 ◽  
Author(s):  
Sube Banerjee
Keyword(s):  
Cost Effectiveness ◽  
Secondary Care ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Treatment Of Depression ◽  
Randomised Controlled

A Comparative Double-Blind Trial of the New Antidepressant Caroxazone and Amitriptyline

1978 ◽  
Vol 6 (5) ◽  
pp. 388-394 ◽  
Author(s):  
S Cecchini ◽  
P Petri ◽  
R Ardito ◽  
S R Bareggi ◽  
A Torriti
Keyword(s):  
Clinical Trials ◽  
Rating Scale ◽  
Pharmacological Properties ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
End Of Treatment ◽  
Treatment Of Depression ◽  
Symptom Scores ◽  
Hamilton Rating Scale

On the grounds of pharmacological properties and preliminary clinical trials the efficacy of the new antidepressant caroxazone was compared to amitriptyline in the management of depression. Forty patients mostly suffering from a neurotic or anxious-neurotic depression were admitted to a double-blind trial. All patients completed the study. The Hamilton Rating Scale for Depression was used for the clinical assessment at the beginning, during and at the end of treatment. The trial lasted three weeks. A significant improvement was seen for both drugs after seven days on most symptom scores and on total symptom score. No significant differences were found either at seven days or at the end of treatment between the two drugs. There were no significant differences in the incidence and severity of side-effects. In conclusion, caroxazone appears as an effective and well tolerated drug in the treatment of depression.

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