Dexamethasone for the treatment of depression: a randomized, placebo- controlled, double-blind trial

1995 ◽  
Vol 152 (2) ◽  
pp. 265-267 ◽  
1978 ◽  
Vol 6 (5) ◽  
pp. 388-394 ◽  
Author(s):  
S Cecchini ◽  
P Petri ◽  
R Ardito ◽  
S R Bareggi ◽  
A Torriti

On the grounds of pharmacological properties and preliminary clinical trials the efficacy of the new antidepressant caroxazone was compared to amitriptyline in the management of depression. Forty patients mostly suffering from a neurotic or anxious-neurotic depression were admitted to a double-blind trial. All patients completed the study. The Hamilton Rating Scale for Depression was used for the clinical assessment at the beginning, during and at the end of treatment. The trial lasted three weeks. A significant improvement was seen for both drugs after seven days on most symptom scores and on total symptom score. No significant differences were found either at seven days or at the end of treatment between the two drugs. There were no significant differences in the incidence and severity of side-effects. In conclusion, caroxazone appears as an effective and well tolerated drug in the treatment of depression.


1981 ◽  
Vol 7 (4) ◽  
pp. 234-240 ◽  
Author(s):  
P. Lemoine ◽  
A. Achaintre ◽  
G. Balvay ◽  
H. Bonnet ◽  
R. Burgat ◽  
...  

1974 ◽  
Vol 2 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Norman Capstick ◽  
Kenneth C Rooke

A double-blind trial comparing the action of opipramol against a combination of phenelzine and chlordiazepoxide in the treatment of depressive states was carried out jointly in a psychiatric out-patient clinic and in a general practice. While both preparations were effective there was no statistically significant difference favouring one agent at the end of the six weeks trial period. Certain advantages occurred with each preparation at different times during the trial period, and these are described in the text.


2007 ◽  
Vol 177 (4S) ◽  
pp. 35-35
Author(s):  
Gianluca Giannarini ◽  
Andrea Mogorovich ◽  
Girolamo Morelli ◽  
Maurizio De Maria ◽  
Francesca Manassero ◽  
...  

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