scholarly journals Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Caroline König ◽  
Martha I Cárdenas ◽  
Jesús Giraldo ◽  
René Alquézar ◽  
Alfredo Vellido
Keyword(s):  
G Protein ◽  
Systematic Approach ◽  
G Protein Coupled Receptors ◽  
Label Noise ◽  
Classification Errors ◽  
Class C ◽  
G Protein Coupled

scholarly journals Minireview: Nutrient Sensing by G Protein-Coupled Receptors

2013 ◽  
Vol 27 (8) ◽  
pp. 1188-1197 ◽  
Author(s):  
Eric M. Wauson ◽  
Andrés Lorente-Rodríguez ◽  
Melanie H. Cobb
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
G Protein ◽  
Taste Receptor ◽  
Sweet Taste ◽  
Nutrient Sensing ◽  
G Protein Coupled Receptors ◽  
Amino Acid Availability ◽  
Class C ◽  
G Protein Coupled

G protein-coupled receptors (GPCRs) are membrane proteins that recognize molecules in the extracellular milieu and transmit signals inside cells to regulate their behaviors. Ligands for many GPCRs are hormones or neurotransmitters that direct coordinated, stereotyped adaptive responses. Ligands for other GPCRs provide information to cells about the extracellular environment. Such information facilitates context-specific decision making that may be cell autonomous. Among ligands that are important for cellular decisions are amino acids, required for continued protein synthesis, as metabolic starting materials and energy sources. Amino acids are detected by a number of class C GPCRs. One cluster of amino acid-sensing class C GPCRs includes umami and sweet taste receptors, GPRC6A, and the calcium-sensing receptor. We have recently found that the umami taste receptor heterodimer T1R1/T1R3 is a sensor of amino acid availability that regulates the activity of the mammalian target of rapamycin. This review focuses on an array of findings on sensing amino acids and sweet molecules outside of neurons by this cluster of class C GPCRs and some of the physiologic processes regulated by them.

scholarly journals Representation Learning for Class C G Protein-Coupled Receptors Classification

Molecules ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 690 ◽  
Author(s):  
Raúl Cruz-Barbosa ◽  
Erik-German Ramos-Pérez ◽  
Jesús Giraldo
Keyword(s):  
G Protein ◽  
Representation Learning ◽  
G Protein Coupled Receptors ◽  
Class C ◽  
G Protein Coupled

Entropy in the alignment and dimerization of class C G-protein coupled receptors

2007 ◽  
pp. 85-93
Author(s):  
M. K. Dean ◽  
C. Higgs ◽  
R. E. Smith ◽  
P. D. Scott ◽  
R. P. Bywater ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Class C ◽  
G Protein Coupled

scholarly journals The activation mechanism of class-C G-protein coupled receptors

2004 ◽  
Vol 96 (5) ◽  
pp. 335-342 ◽  
Author(s):  
J.-P Pin ◽  
J Kniazeff ◽  
C Goudet ◽  
A.-S Bessis ◽  
J Liu ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Activation Mechanism ◽  
Class C ◽  
G Protein Coupled

scholarly journals Allosteric functioning of dimeric class C G-protein-coupled receptors

FEBS Journal ◽  
2005 ◽  
Vol 272 (12) ◽  
pp. 2947-2955 ◽  
Author(s):  
J-P. Pin ◽  
J. Kniazeff ◽  
J. Liu ◽  
V. Binet ◽  
C. Goudet ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Class C ◽  
G Protein Coupled

scholarly journals Class C G protein-coupled receptors: reviving old couples with new partners

2017 ◽  
Vol 3 (4-6) ◽  
pp. 57-63 ◽  
Author(s):  
Thor C. Møller ◽  
David Moreno-Delgado ◽  
Jean-Philippe Pin ◽  
Julie Kniazeff
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Class C ◽  
G Protein Coupled
Sign in / Sign up

Export Citation Format

Share Document