scholarly journals Indirect comparison of the diagnostic performance of 18F-FDG PET/CT and MRI in differentiating benign and malignant ovarian or adnexal tumors: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xianwen Hu ◽  
Dandan Li ◽  
Zhigang Liang ◽  
Yan Liao ◽  
Ling Yang ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Indirect Comparison ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Adnexal Tumors ◽  
Ct And Mri

Abstract Objective To compare the value of fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging (MRI) in differentiating benign and malignant ovarian or adnexal tumors. Materials and methods English articles reporting on the diagnostic performance of MRI or 18F-FDG PET/CT in identifying benign and malignant ovarian or adnexal tumors published in PubMed and Embase between January 2000 and January 2021 were included in the meta-analysis. Two authors independently extracted the data. If the data presented in the study report could be used to construct a 2 × 2 contingency table comparing 18F-FDG PET/CT and MRI, the studies were selected for the analysis. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to evaluate the quality of the included studies. Forest plots were generated according to the sensitivity and specificity of 18F-FDG PET/CT and MRI. Results A total of 27 articles, including 1118F-FDG PET/CT studies and 17 MRI studies on the differentiation of benign and malignant ovarian or adnexal tumors, were included in this meta-analysis. The pooled sensitivity and specificity for 18F-FDG PET/CT in differentiating benign and malignant ovarian or adnexal tumors were 0.94 (95% CI, 0.87–0.97) and 0.86 (95% CI, 0.79–0.91), respectively, and the pooled sensitivity and specificity for MRI were 0.92 (95% CI: 0.89–0.95) and 0.85 (95% CI: 0.79–0.89), respectively. Conclusion While MRI and 18F-FDG PET/CT both showed to have high and similar diagnostic performance in the differential diagnosis of benign and malignant ovarian or adnexal tumors, MRI, a promising non-radiation imaging technology, may be a more suitable choice for patients with ovarian or accessory tumors. Nonetheless, prospective studies directly comparing MRI and 18F-FDG PET/CT diagnostic performance in the differentiation of benign and malignant ovarian or adnexal tumors are needed.

scholarly journals The diagnostic performance of 18F-FDG PET/CT and MRI in differentiating benign and malignant ovarian tumors: an indirect comparative analysis

2021 ◽  
Author(s):  
Xianwen Hu ◽  
Dandan Li ◽  
Zhigang Liang ◽  
Yan Liao ◽  
Ling Yang ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Malignant Tumors ◽  
Meta Analysis ◽  
Ovarian Tumors ◽  
Scanning Time ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Ct And Mri

Abstract Objective: To compare the value of Fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging(MRI) in differentiating benign and malignant ovarian tumors.Material and Methods: Retrieved the research on the diagnostic performance of MRI or 18F-FDG PET/CT in identifying benign and malignant ovarian tumors published in PubMed and Embase from January 2000 to January 2021. Two authors independently extracted the data of the characteristics of each study. If the data of the study report can be used to construct a 2X2 contingency table comparing 18F-FDG PET/CT and MRI, these studies were selected. The Quality Assessment of Diagnostic Accuracy Studies were used to evaluate the quality of the studies. According to the sensitivity and specificity of 18F-FDG PET/CT and MRI, forest plots is generated.Results：A total of 27 articles including 1118F-FDG PET/CT studies and 17 MRI studies on the differentiation of benign and malignant ovarian or accessory tumors were included for this meta-analysis. The pooled sensitivity and specificity for 18F-FDG PET/CT in differentiating benign and malignant ovarian tumors were 0.92 (95% CI, 0.86-0.96) and 0.86 (95% CI, 0.79-0.91), respectively, and the pooled sensitivity and specificity for MRI were 0.92 (95% CI: 0.89-0.95) and 0.85 (95% CI: 0.79-0.89), respectively.Conclusion：MRI and 18F-FDG PET/CT have the same diagnostic performance in the differential diagnosis of ovarian benign and malignant tumors. However, MRI is more worthy of clinical application because of its lack of radiation, shorter scanning time, and lower medical costs.

scholarly journals Diagnostic performance of 18F-FDG PET/CT in patients with spinal infection: a systematic review and a bivariate meta-analysis

2019 ◽  
Vol 47 (5) ◽  
pp. 1287-1301 ◽  
Author(s):  
Giorgio Treglia ◽  
Mariarosa Pascale ◽  
Elena Lazzeri ◽  
Wouter van der Bruggen ◽  
Roberto C. Delgado Bolton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Spinal Infection ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

18F-FDG PET, combined FDG-PET/CT and MRI for evaluation of bone marrow infiltration in staging of lymphoma: A systematic review and meta-analysis

2012 ◽  
Vol 81 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Lian-Ming Wu ◽  
Fang-Yuan Chen ◽  
Xiao-Xing Jiang ◽  
Hai-Yan Gu ◽  
Yan Yin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Marrow ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Bone Marrow Infiltration ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ct And Mri

Meta-Analysis of the Diagnostic Performance of 18F-FDG-PET/CT Imaging in Native Valve Endocarditis

2020 ◽  
Author(s):  
Domenico Albano ◽  
Francesco Dondi ◽  
Maria Gazzilli ◽  
Raffaele Giubbini ◽  
Francesco Bertagna
Keyword(s):  
Fdg Pet ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Ct Imaging ◽  
Native Valve ◽  
Native Valve Endocarditis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic Accuracy of 18F-FDG-PET/CT and MRI in Predicting the Tumor Response in Locally Advanced Cervical Carcinoma Treated by Chemoradiotherapy: A Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Sharareh Sanei Sistani ◽  
Fateme Parooie ◽  
Morteza Salarzaei
Keyword(s):  
Diagnostic Accuracy ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Advanced Cervical Carcinoma ◽  
Pet Ct ◽  
18F Fdg ◽  
Diagnostic Sensitivity And Specificity ◽  
Fdg Pet Ct ◽  
Ct And Mri

Objective. The aim of this meta-analysis was to compare the diagnostic accuracy of 18F-FDG-PET/CT and MRI in predicting the tumor response in locally advanced cervical carcinoma (LACC) treated by chemoradiotherapy (CRT). Method. This meta-analysis has been performed according to PRISMA guidelines. Systematic searches were conducted using PubMed and Embase databases for articles published from January 1, 2010, to January 1, 2020. By using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool, the reviewers assessed the methodological quality scores of the selected studies. We analyzed the sensitivity, specificity, and accuracy of two diagnostic methods using Meta-DiSc 1.4 and Stata 15. Results. An overall of 15 studies including 1132 patients were included. Sensitivities of PET/CT and MRI were 83.5% and 82.7%, while the corresponding rates for specificities were 77.8% and 68.4%, respectively. The DOR, PLR, and NLR for MRI were 15.140, 2.92, and 22.6. PET/CT had a DOR of 25.21. The PLR and NLR for PET/CT were 4.13 and 0.215, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of residual tumor were 86% and 95%, respectively. The corresponding rates for MRI were 73% and 96%, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of tumor metastases were 97% and 99%, while the corresponding rates for MRI were 31% and 98%, respectively. Conclusion. 18F-FDG PET/CT seemed to have a better overall diagnostic accuracy in the evaluation of treatment response to chemoradiotherapy in LACC patients. MRI showed a really poor sensitivity in the detection of metastases, and PET/CT performed significantly better. However, the difference between these two methods in the detection of residual disease was not significant. More studies are needed to be conducted in order to approve that 18F-FDG PET/CT can be a standard option to assess the treatment response.

scholarly journals The Role of18F-FDG PET/CT and MRI in Assessing Pathological Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Qiufang Liu ◽  
Chen Wang ◽  
Panli Li ◽  
Jianjun Liu ◽  
Gang Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Sensitivity And Specificity ◽  
Fdg Pet ◽  
Pathological Complete Response ◽  
Meta Analysis ◽  
Complete Response ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Ct And Mri

Purpose. We performed this meta-analysis to determine the utilities of18F-FDG PET/CT and MRI in assessing the pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in the same cohort of patients with breast cancer.Methods. Two reviewers systematically searched on PubMed, Scopus, and Springer (from the beginning of 1992 to Aug. 1, 2015) for the eligible articles. Heterogeneity, pooled sensitivity and specificity, positive likelihood ratio, negative likelihood ratio, and the summary receiver operating characteristic (SROC) curve were calculated to estimate the diagnostic efficacy of18F-FDG PET/CT and MRI.Results. A total of 6 studies including 382 pathologically confirmed patients were eligible. The pooled sensitivity and specificity of18F-FDG PET/CT were 0.86 (95% CI: 0.76–0.93) and 0.72 (95% CI: 0.49–0.87), respectively. Pooled sensitivity and specificity of MRI were 0.65 (95% CI: 0.45–0.80) and 0.88 (95% CI: 0.75–0.95), respectively. The area under the SROC curve of18F-FDG PET/CT and MRI was 0.88 and 0.84, respectively.Conclusion. Study indicated that18F-FDG PET/CT had a higher sensitivity and MRI had a higher specificity in assessing pCR in breast cancer patients. Therefore, the combined use of these two imaging modalities may have great potential to improve the diagnostic performance in assessing pCR after NAC.

scholarly journals Diagnostic Performance of 18F-FDG PET(CT) in Bone-Bone Marrow Involvement in Pediatric Neuroblastoma: A Systemic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Lixin Sun ◽  
Bingye Zhang ◽  
Ruchen Peng
Keyword(s):  
Bone Marrow ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Bone Marrow Involvement ◽  
Systemic Review ◽  
Pet Ct ◽  
Statistical Heterogeneity ◽  
18F Fdg ◽  
Fdg Pet Ct

Objective. We sought to perform a systemic review and meta-analysis of the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (computed tomography) (PET(CT)) in detection of bone and/or bone marrow involvement (BMI) in pediatric neuroblastoma (NB). Materials and Methods. We searched electronic databases Pubmed and Embase to retrieve relevant references. We calculated pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR−), diagnostic odds ratio (DOR), and the area under the curve (AUC). Moreover, a summary receiver operating characteristic (SROC) curve and likelihood ratio dot plot were plotted. Study-between statistical heterogeneity was evaluated via I-square index (I2). Subgroup analyses were used to explore heterogeneity. Results. Seven studies including 127 patients were involved in this meta-analysis. The overall sensitivity and specificity were 0.87 (95% CI: 0.65–0.96) with heterogeneity I2 = 88.1% ( p < 0.001 ) and 0.96 (95% CI: 0.67–1.00) with heterogeneity I2 = 77.8% ( p < 0.001 ), respectively. The pooled LR+, LR−, and DOR were 21.3 (95% CI: 2.1–213.9), 0.14 (95% CI: 0.05–0.40), and 157 (95% CI: 16–1532), respectively. The area under the SROC curve was 0.97 (95% CI: 0.95–0.98). Conclusions. Through a meta-analysis, this study suggested that 18F-FDG PET(CT) has a good overall diagnostic accuracy in the detection of bone/BMI in pediatric neuroblastoma.

Contribution of 18F-FDG PET/CT in a case-mix of fever of unknown origin and inflammation of unknown origin: a meta-analysis

2018 ◽  
Vol 60 (6) ◽  
pp. 716-725 ◽  
Author(s):  
Ying Kan ◽  
Wei Wang ◽  
Jie Liu ◽  
Jigang Yang ◽  
Zhenchang Wang
Keyword(s):  
Likelihood Ratio ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Fever Of Unknown Origin ◽  
Meta Analysis ◽  
Unknown Origin ◽  
Number Of Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Background Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are challenging medical problems. Previous studies have shown that 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) plays an important role in the diagnosis of FUO, but few studies have explored this diagnostic technique in relation to IUO. Purpose To systematically review and perform a meta-analysis of published data on the diagnostic performance of PET/CT in the diagnosis of FUO and IUO. Material and Methods A comprehensive literature search was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines published in March 2018. Meta-analysis of diagnostic performance was performed using STATA 12.0 software. Subgroup analysis was performed by stratification based on study design, number of patients, geographic area, and final diagnosis based on 18F-FDG PET/CT. Meta-regression analyses were performed to recognize heterogeneity. Results Our meta-analysis included 23 studies, comprising a total sample size of 1927 patients. The pooled diagnosis performance was calculated with a per-patient-based analysis: sensitivity = 0.84 (95% confidence interval [CI] = 0.79–0.89), specificity = 0.63 (95% CI = 0.49–0.75), positive likelihood ratio = 2.3 (95% CI = 1.5–3.4), negative likelihood ratio = 0.25 (95% CI = 0.16–0.38), diagnostic odds ratio = 9 (95% CI = 4.0–20), and AUC = 0.84 (95% CI = 0.81–0.87). Conclusion In patients with non-specific symptoms and signs, 18F-FDG PET/CT is very helpful for recognizing and excluding diseases, directing further diagnostic decisions, and avoiding unnecessary invasive examinations. We recommend that 18F-FDG PET/CT should be considered among the first-line diagnostic tools for patients with FUO and IUO.

Sign in / Sign up

Export Citation Format

Share Document