Retinal blood flow is increased in type 1 diabetes mellitus patients with advanced stages of retinopathy

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler ﬂowmetry in children with diﬀerent experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler ﬂowmetry using a laser analyzer for capillary blood ﬂow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood ﬂow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac ﬂuctuations, low efciency and redistribution of blood ﬂow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the eﬀectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outﬂow.

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Effects of C-peptide on forearm blood flow and brachial artery dilatation in patients with type 1 diabetes mellitus

Acta Physiologica Scandinavica ◽

10.1046/j.1365-201x.2001.00860.x ◽

2001 ◽

Vol 172 (3) ◽

pp. 159-165 ◽

Cited By ~ 21

Author(s):

E. Fernqvist-Forbes ◽

B.-L. Johansson ◽

M. J. Eriksson

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Brachial Artery ◽

Forearm Blood Flow ◽

C Peptide

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The Effects of Plasma Insulin and Glucose on Myocardial Blood Flow in Patients With Type 1 Diabetes Mellitus

Yearbook of Cardiology ◽

10.1016/s0145-4145(07)70150-8 ◽

2006 ◽

Vol 2006 ◽

pp. 241-242

Author(s):

B.J. Gersh

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Myocardial Blood Flow ◽

Type 1 Diabetes Mellitus ◽

Plasma Insulin

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Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans

Circulation ◽

10.1161/circulationaha.110.992297 ◽

2011 ◽

Vol 124 (14) ◽

pp. 1548-1556 ◽

Cited By ~ 46

Author(s):

Omar Rana ◽

Christopher D. Byrne ◽

David Kerr ◽

David V. Coppini ◽

Soha Zouwail ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Myocardial Blood Flow ◽

Type 1 Diabetes Mellitus ◽

Healthy Humans ◽

Flow Reserve ◽

Acute Hypoglycemia ◽

Myocardial Blood Flow Reserve

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Elevated Skeletal Muscle Blood Flow in Noncomplicated Type 1 Diabetes Mellitus

Hypertension ◽

10.1161/01.hyp.34.5.1080 ◽

1999 ◽

Vol 34 (5) ◽

pp. 1080-1085 ◽

Cited By ~ 30

Author(s):

Gerald Vervoort ◽

Jack F. Wetzels ◽

Jos A. Lutterman ◽

Laurus G. van Doorn ◽

Jo H. Berden ◽

...

Keyword(s):

Diabetes Mellitus ◽

Skeletal Muscle ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Muscle Blood Flow ◽

Skeletal Muscle Blood Flow

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Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration

Scientific Reports ◽

10.1038/s41598-021-83484-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Galina Yankova ◽

Darya Tur ◽

Daniil Parshin ◽

Alexander Cherevko ◽

Andrey Akulov

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Cross Sections ◽

Cfd Simulation ◽

Blood Flow Rate ◽

Cfd Modeling ◽

Blood Flow Modeling

AbstractType 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies.

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Early Changes of Blood Flow Parameters of Ophthalmic Artery in Patients with Type 1 Diabetes Mellitus

Beyoglu Eye Journal ◽

10.14744/bej.2020.15238 ◽

2020 ◽

Author(s):

Serdar Ozates

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Ophthalmic Artery ◽

Flow Parameters

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Peculiarities of microcirculation in peridont tissues in children of key age groups sufficient type 1 diabetes. Part I

Periodontology ◽

10.25636/pmp.1.2019.1.1 ◽

2019 ◽

Vol 24 (1) ◽

pp. 4-10

Author(s):

B. N. Davydov ◽

D. A. Domenyk ◽

S. V. Dmitrienko

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Laser Doppler Flowmetry ◽

Laser Doppler ◽

Diabetic Microangiopathy ◽

Healthy Children ◽

Doppler Flowmetry

The relevance of the research topic. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders.Purpose – identifcation of microcirculation features of the blood by the method of laser Doppler ﬂowmetry in children with different experience of type 1 diabetes in key age categories.Methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler ﬂowmetry using a laser analyzer for capillary blood ﬂow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood ﬂow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac ﬂuctuations, low effciency and redistribution of blood ﬂow in favor of the nutritive link.Summary. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early - compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late - decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outﬂow.

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