scholarly journals Quantitative evaluation of activity of thyroid-associated Ophthalmopathy using short-tau inversion recovery (STIR) sequence

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qian Ge ◽  
Xiaohui Zhang ◽  
Lu Wang ◽  
Yao Fan ◽  
Qian Huang ◽  
...  
Keyword(s):  
Disease Activity ◽  
Signal Intensity ◽  
Extraocular Muscles ◽  
Inversion Recovery ◽  
Clinical Activity ◽  
Roc Curve Analysis ◽  
Inferior Rectus ◽  
Good Efficiency ◽  
Stir Sequence ◽  
Short Tau Inversion Recovery

Abstract Objective Quantitatively staging TAO using MRI remains limited. Our study aims to identify the cut-off signal intensity value for staging TAO using STIR sequence scan. Methods Between June 2018 and July 2020, a number of 51 patients with TAO (102 eyes) and 19 volunteer controls (38 eyes) were recruited. The clinical and biochemical parameters were measured in each patient. Disease activity was diagnosed based on the Clinical Activity Score (CAS). The signal intensities of extraocular muscles were scanned using short-tau inversion recovery (STIR) sequences from MRI. Results Compared to the inactive TAO patients and the controls, the signal intensity ratios (SIRs) of the superior rectus, inferior rectus, medial rectus, lateral rectus on STIR images were significantly increased in the active TAO patients. After adjustment for age and smokers, the SIRs of four extraocular muscles showed strong associations with CAS. By receiver operator characteristic (ROC) curve analysis, all four muscle SIRs demonstrated good efficiency for predicting disease activity [area under curve (AUC) 0.75–0.83, all P < 0.01]. The identified cut-off SIR values were further validated in a new group of TAO patients (30 eyes) enrolled between September 2020 and January 2021. The cut-off SIR value of > 2.9 in the inferior rectus showed optimal diagnostic value for staging the active TAO. Conclusions the signal intensity of extraocular muscles on STIR sequence was a good predictor for TAO activity. A cut-off SIR value of > 2.9 in the inferior rectus could be applied to evaluate the active stage of TAO.

Evaluation of extraocular muscles in patients with thyroid associated ophthalmopathy using apparent diffusion coefficient measured by magnetic resonance imaging before and after radiation therapy

2021 ◽  
pp. 028418512110340
Author(s):  
Wu Yu ◽  
Lao Zheng ◽  
Zhang Shuo ◽  
Liu Xingtong ◽  
Jiang Mengda ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Radiation Therapy ◽  
Apparent Diffusion Coefficient ◽  
Extraocular Muscles ◽  
Clinical Activity ◽  
Inferior Rectus ◽  
Thyroid Associated Ophthalmopathy ◽  
Before And After ◽  
Apparent Diffusion ◽  
The Mean

Background Thyroid-associated ophthalmopathy (TAO) is an autoimmune orbital disease characterized by edema of extraocular muscles (EOMs). Purpose To characterize the inflammation of EOMs in patients with TAO before and after radiation therapy using apparent diffusion coefficient (ADC) and to analyze the correlation between ADC and clinical activity of TAO. Material and Methods The ADCs of superior rectus (SR), inferior rectus (IR), medial rectus (MR), and lateral rectus (LR) muscles were measured in 52 eyes of 26 patients with TAO before and three months after orbital radiation therapy. In addition, 38 eyes of 20 healthy volunteers were included. The clinical activity score (CAS) was evaluated. The ADC maps were reconstructed and measured on the coronal diffusion-weighted imaging (DWI) sequence and calculated in mm2/s. Results The mean ADCs of EOMs before treatment were 1.42 ± 0.23 in SR, 1.37 ± 0.23 in IR, 1.41 ± 0.21 in MR, and 1.28 ± 0.25 in LR. The mean ADCs after treatment were 1.27 ± 0.18, 1.22 ± 0.26, 1.30 ± 0.22, and 1.15 ± 0.21, respectively. The ADCs were significantly decreased after treatment (all P < 0.001). The ADCs of patients with TAO were significantly higher than those of controls. There was a statistically significant correlation between the mean ADCs and the CAS in each patient with TAO both before and after treatment (before: r = 0.520; P < 0.001; after: r = 0.625; P < 0.001). Conclusion The ADC values of EOMs can be exploited as a quantitative indicator to evaluate the clinical activity and monitor the therapeutic responses of patients with TAO.

Grading of Inflammatory Disease Activity in the Sacroiliac Joints with Magnetic Resonance Imaging: Comparison Between Short-tau Inversion Recovery and Gadolinium Contrast-enhanced Sequences

2009 ◽  
Vol 37 (2) ◽  
pp. 393-400 ◽  
Author(s):  
KAREN BERENTH MADSEN ◽  
NIELS EGUND ◽  
ANNE GRETHE JURIK
Keyword(s):  
Bone Marrow ◽  
Magnetic Resonance ◽  
Image Resolution ◽  
Inversion Recovery ◽  
Sacroiliac Joints ◽  
Gadolinium Contrast ◽  
Fatty Replacement ◽  
Stir Sequence ◽  
Short Tau Inversion Recovery ◽  
Marrow Activity

Objective. We investigated the potential concordance of 2 different magnetic resonance (MR) sequences — short-tau inversion recovery (STIR) and fat-saturated T1-weighted spin-echo after application of gadolinium (Gd) contrast medium to detect active bone marrow abnormalities at the sacroiliac joints (SIJ) in patients with spondyloarthritis (SpA).Methods. Blinded and using the Danish scoring method, we evaluated transaxial MR images of the 2 sequences in 40 patients with SpA with disease duration of 3–14 years. Both the cartilaginous and ligamentous portions of the SIJ were analyzed.Results. There was a significant positive correlation between the activity scores obtained by STIR and Gd-enhanced sequences (p < 0.0001). Agreement in the detection of bone marrow abnormalities occurred in 60 of the 80 joints, 35 with and 25 without signs of active disease. Discordance with STIR-positive marrow activity scores occurred in only 11 joints; Gd-enhanced positive scores in 9 joints. The STIR sequence detected remnants of marrow activity in the periphery of chronic fatty replacement not seen or partly obscured on the Gd sequence. Small subchondral enhancing lesions may not be scored on the STIR sequence, mostly because of reduced image resolution.Conclusion. Active bone marrow abnormalities were detected nearly equally well with STIR and Gd-enhanced fat-suppressed T1 sequences in patients with SpA, with STIR being most sensitive to visualize active abnormalities in the periphery of chronic changes.

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