scholarly journals Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network

2018 ◽  
Vol 12 (S4) ◽  
Author(s):  
Abbas Khan ◽  
Arif Ali ◽  
Muhammad Junaid ◽  
Chang Liu ◽  
Aman Chandra Kaushik ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Drug Targets ◽  
Interaction Network ◽  
Protein Protein Interaction ◽  
Diamond Blackfan Anemia ◽  
Novel Drug ◽  
Protein Protein Interaction Network ◽  
Novel Drug Targets

scholarly journals Application of Thermodynamics and Protein–Protein Interaction Network Topology for Discovery of Potential New Treatments for Temporal Lobe Epilepsy

2021 ◽  
Vol 11 (17) ◽  
pp. 8059
Author(s):  
Chang Yu ◽  
Edward A. Rietman ◽  
Hava T. Siegelmann ◽  
Marco Cavaglia ◽  
Jack A. Tuszynski
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Ribosomal Proteins ◽  
Drug Targets ◽  
Interaction Network ◽  
Current Standard ◽  
Protein Protein Interaction ◽  
Protein Protein Interaction Network

In this paper, we propose a bioinformatics-based method, which introduces thermodynamic measures and topological characteristics aimed to identify potential drug targets for pharmaco-resistant epileptic patients. We apply the Gibbs homology analysis to the protein–protein interaction network characteristic of temporal lobe epilepsy. With the identification of key proteins involved in the disease, particularly a number of ribosomal proteins, an assessment of their inhibitors is the next logical step. The results of our work offer a direction for future development of prospective therapeutic solutions for epilepsy patients, especially those who are not responding to the current standard of care.

Sign in / Sign up

Export Citation Format

Share Document