scholarly journals A pilot study of ezetimibe vs. atorvastatin for improving peripheral microvascular endothelial function in stable patients with type 2 diabetes mellitus

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Seigo Sugiyama ◽  
Hideaki Jinnouchi ◽  
Kunio Hieshima ◽  
Noboru Kurinami ◽  
Tomoko Suzuki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Endothelial Function ◽  
Microvascular Endothelial ◽  
Microvascular Endothelial Function

scholarly journals Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus

2016 ◽  
Vol 101 (11) ◽  
pp. 3952-3958 ◽  
Author(s):  
Oskar Kövamees ◽  
Alexey Shemyakin ◽  
Antonio Checa ◽  
Craig E. Wheelock ◽  
Jon O. Lundberg ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Function ◽  
Microvascular Endothelial ◽  
Microvascular Endothelial Function

scholarly journals Effects of erythritol on endothelial function in patients with type 2 diabetes mellitus: a pilot study

2013 ◽  
Author(s):  
Nir Flint ◽  
Naomi M. Hamburg ◽  
Monika Holbrook ◽  
Pamela G. Dorsey ◽  
Rebecca M. LeLeiko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Endothelial Function

scholarly journals Seven-day remote ischaemic preconditioning improves endothelial function in patients with type 2 diabetes mellitus: a randomised pilot study

2019 ◽  
Vol 181 (6) ◽  
pp. 659-669
Author(s):  
Joseph D Maxwell ◽  
Howard H Carter ◽  
Ylva Hellsten ◽  
Gemma D Miller ◽  
Victoria S Sprung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Endothelial Function ◽  
Sample Size ◽  
Ischaemic Preconditioning ◽  
Cerebrovascular Function ◽  
Remote Ischaemic Preconditioning

Background Remote ischaemic preconditioning (rIPC) may improve cardiac/cerebrovascular outcomes of ischaemic events. Ischaemic damage caused by cardiovascular/cerebrovascular disease are primary causes of mortality in type 2 diabetes mellitus (T2DM). Due to the positive effects from a bout of rIPC within the vasculature, we explored if daily rIPC could improve endothelial and cerebrovascular function. The aim of this pilot study was to obtain estimates for the change in conduit artery and cerebrovascular function following a 7-day rIPC intervention. Methods Twenty-one patients with T2DM were randomly allocated to either 7-day daily upper-arm rIPC (4 × 5 min 220 mmHg, interspaced by 5-min reperfusion) or control. We examined peripheral endothelial function using flow mediated dilation (FMD) before and after ischemia-reperfusion injury (IRI, 20 min forearm ischaemic-20 min reperfusion) and cerebrovascular function, assessed by dynamic cerebral autoregulation (dCA) at three time points; pre, post and 8 days post intervention. Results For exploratory purposes, we performed statistical analysis on our primary comparison (pre-to-post) to provide an estimate of the change in the primary and secondary outcome variables. Using pre-intervention data as a covariate, the change from pre-post in FMD was 1.3% (95% CI: 0.69 to 3.80; P = 0.09) and 0.23 %cm/s %/mmHg mmHg/% (−0.12, 0.59; P = 0.18) in dCA normalised gain with rIPC versus control. Based upon this, a sample size of 20 and 50 for FMD and normalised gain, respectively, in each group would provide 90% power to detect statistically significant (P < 0.05) between-group difference in a randomised controlled trial. Conclusion We provide estimates of sample size for a randomised control trial exploring the impact of daily rIPC for 7 days on peripheral endothelial and cerebrovascular function. The directional changes outline from our pilot study suggest peripheral endothelial function can be enhanced by daily rIPC in patients with T2DM.

1131-P: Endoscopic Duodenal Submucosal Laser Ablation for the Treatment of Type 2 Diabetes Mellitus: Results of First-in-Human Pilot Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1131-P ◽  
Author(s):  
MILOS MRAZ ◽  
IDAN MARCOVITCH ◽  
IVANA LANKOVA ◽  
HELENA KRATOCHVILOVA ◽  
ANNA CINKAJZLOVA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Laser Ablation ◽  
Pilot Study

An alcohol-free beer enriched with isomaltulose and a resistant dextrin modulates gut microbiome in subjects with type 2 diabetes mellitus and overweight or obesity: a pilot study

2021 ◽  
Author(s):  
Rocío Mateo-Gallego ◽  
Isabel Moreno-Indias ◽  
Ana M. Bea ◽  
Lidia Sánchez-Alcoholado ◽  
Antonio J. Fumanal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Low Doses ◽  
Resistant Dextrin ◽  
Overweight Or Obesity

An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and maltodextrin within meals significantly impacts gut microbiota in diabetic subjects with overweight or obesity.

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