scholarly journals Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Toshihisa Kimura ◽  
Tamotsu Togawa ◽  
Atsushi Iida ◽  
Sakon Noriki ◽  
Yasunori Sato ◽  
...  
Keyword(s):  
Cellular Senescence ◽  
Sarcomatoid Carcinoma ◽  
Immunohistochemical Analysis ◽  
Point Of View ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of The Pancreas ◽  
Underlying Mechanisms ◽  
Short Term Survival

Abstract Aim Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient’s long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis. Findings The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.

scholarly journals Long-term survival after resection of sarcomatoid carcinoma of the pancreas: an updated experience

2017 ◽  
Vol 219 ◽  
pp. 238-243 ◽  
Author(s):  
Alex B. Blair ◽  
Richard A. Burkhart ◽  
James F. Griffin ◽  
James A. Miller ◽  
Matthew J. Weiss ◽  
...  
Keyword(s):  
Sarcomatoid Carcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of The Pancreas

scholarly journals Sarcomatoid carcinoma of the pancreas with rare long-term survival: a case report

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Toshihisa Kimura ◽  
Daisuke Fujimoto ◽  
Tamotsu Togawa ◽  
Makoto Ishida ◽  
Atsushi Iida ◽  
...  
Keyword(s):  
Case Report ◽  
Sarcomatoid Carcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of The Pancreas

Nonfunctioning islet cell carcinoma of the pancreas: An evaluation of seven patients who underwent resection followed by long-term survival

Surgery Today ◽  
1999 ◽  
Vol 29 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Naofumi Eriguchi ◽  
Shigeaki Aoyagi ◽  
Masao Hara ◽  
Shuichi Fukuda ◽  
Eiji Tanaka ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Islet Cell ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of The Pancreas ◽  
Islet Cell Carcinoma ◽  
Nonfunctioning Islet Cell Carcinoma

Nonfunctioning Islet Cell Carcinoma of the Pancreas: An Evaluation of Seven Patients Who Underwent Resection Followed by Long-Term Survival

Surgery Today ◽  
1999 ◽  
Vol 29 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Naofumi Eriguchi ◽  
Shigeaki Aoyagi ◽  
Masao Hara ◽  
Shuichi Fukuda ◽  
Eiji Tanaka ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Islet Cell ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of The Pancreas ◽  
Islet Cell Carcinoma ◽  
Nonfunctioning Islet Cell Carcinoma

scholarly journals CT findings and the prognostic value of the Koret CT score in cats with traumatic brain injury

2021 ◽  
pp. 1098612X2110053
Author(s):  
Ohad Mann ◽  
Dana Peery ◽  
Ronnie Bader Segev ◽  
Sigal Klainbart ◽  
Efrat Kelmer ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Intracranial Haemorrhage ◽  
Ct Scans ◽  
Short Term ◽  
Term Survival ◽  
Long Term Survival ◽  
Head Ct ◽  
Ct Findings ◽  
Short Term Survival

Objectives The aims of this study were to evaluate associations between abnormal head CT findings and outcome, and to examine the prognostic value of the Koret CT score (KCTS) in cats sustaining acute traumatic brain injury (TBI). Methods The medical records of cats hospitalised with TBI that underwent head CT scans within 72 h of admission were retrospectively reviewed. CT scans were evaluated independently by a radiologist and a neurologist who were blinded to the outcome. A KCTS and modified Glasgow Coma Scale (MGCS) were assigned to each cat and the association between abnormal CT findings, KCTS, MGCS and outcome were analysed. Results Fourteen cats were included in the study: nine (64.2%) survivors and five (35.7%) non-survivors. Of the nine cats that were discharged, one was a short-term survivor (10 days) and eight (57.1%) were long-term survivors (⩾6 months). Abnormal CT findings included lateral ventricle asymmetry/midline shift (42.8%), intracranial haemorrhage (35.7%), caudotentorial lesions (14.2%) and cranial vault fractures (14.2%), all of which were depressed. Intracranial haemorrhage was found to be significantly and negatively associated with short-term ( P = 0.005) and long-term ( P = 0.023) survival. KCTS was significantly associated with short-term survival ( P = 0.002) and long-term survival ( P = 0.004). A KCTS cut-off value of 2 yielded a 100% sensitivity and 100% specificity for short-term survival and 100% sensitivity and 80% specificity for long-term survival. A MGCS cut-off value of ⩾13 was associated with a 100% sensitivity and 100% specificity for short-term survival, and with a 100% sensitivity and 80% specificity for long-term survival. Conclusions and relevance KCTS, performed up to 72 h from injury, can be used as an additional diagnostic tool for the prediction of survival in cats with TBI.

scholarly journals Transcriptomic Response of Listeria monocytogenes during the Transition to the Long-Term-Survival Phase

2011 ◽  
Vol 77 (17) ◽  
pp. 5966-5972 ◽  
Author(s):  
Jia Wen ◽  
Xiangyu Deng ◽  
Zengxin Li ◽  
Edward G. Dudley ◽  
Ramaswamy C. Anantheswaran ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Cell Envelope ◽  
Growth Stages ◽  
Transcriptomic Response ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
Serotype 4B ◽  
Underlying Mechanisms

ABSTRACTListeria monocytogenescan change its cellular morphology from bacilli to cocci during the transition to the long-term-survival (LTS) phase. The LTS cells demonstrated increased baro- and thermotolerance compared to their vegetative counterparts. So far, the underlying mechanisms that trigger this morphological and physiological transition remain largely unknown. In this study, we compared the transcriptomic profiles ofL. monocytogenesserotype 4b strain F2365 at different growth stages in tryptic soy broth with yeast extract (TSBYE) using a whole-genome DNA chip approach. We identified a total of 225 differentially expressed genes (≥4-fold;P< 0.05) during the transition to the LTS phase in TSBYE. Genes related to cell envelope structure, energy metabolism, and transport were most significantly upregulated in the LTS phase. The upregulation of compatible solute transporters may lead to the accumulation of cellular solutes, lowering intracellular water activity and thus increasing bacterial stress resistance during the transition to the LTS phase. The downregulation of genes associated with protein synthesis may indicate a status of metabolic dormancy of the LTS cells. The transcriptomic profiles of resuscitated LTS cells in fresh TSBYE resembled those of log-phase cells (r=0.94), as the LTS cells rapidly resume metabolic activities and transit back to log phase with decreased baro- and thermotolerance.

Association Between the Most Frequent Complications After Surgery for Stage I–III Colon Cancer and Short-Term Survival, Long-Term Survival, and Recurrences

2016 ◽  
Vol 23 (9) ◽  
pp. 2858-2865 ◽  
Author(s):  
A. J. Breugom ◽  
D. T. van Dongen ◽  
E. Bastiaannet ◽  
F. W. Dekker ◽  
L. G. M. van der Geest ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stage I ◽  
Short Term ◽  
Term Survival ◽  
Long Term Survival ◽  
Short Term Survival

Intraductal papillary components in invasive ductal carcinoma of the pancreas are associated with long-term survival of patients

2001 ◽  
Vol 32 (8) ◽  
pp. 834-841 ◽  
Author(s):  
Noriyoshi Fukushima ◽  
Michiie Sakamoto ◽  
Kiyoshi Mukai ◽  
Yae Kanai ◽  
Kazuaki Shimada ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of The Pancreas
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