scholarly journals Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Merav Heshin-Bekenstein ◽  
Liat Perl ◽  
Aimee O. Hersh ◽  
Emily von Scheven ◽  
Ed Yelin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Adult Height ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Final Adult Height ◽  
Sectional Analysis ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Findings and Feasibility of Major Salivary Gland Ultrasound in Childhood-Onset Systemic Lupus Erythematosus: A Pilot Study

2020 ◽  
Author(s):  
Joseph McDonald ◽  
Patricia Vega-Fernandez ◽  
Tracy Ting
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Salivary Gland ◽  
Lupus Erythematosus ◽  
Major Salivary Gland ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Clinic Setting ◽  
Igg Level ◽  
Onset Systemic Lupus Erythematosus

Abstract Background: Childhood-onset systemic lupus erythematosus (cSLE) is a complex autoimmune disorder with multi-organ manifestations and can be associated with other rheumatic diseases including Sjögren’s syndrome (SS). Salivary gland ultrasound (SGUS) represents a noninvasive tool to screen for salivary gland disease in rheumatic disease patients. The aims of this cross-sectional study were to determine feasibility of major SGUS in a clinic setting and to identify characteristics in a cohort of cSLE patients (without confirmed SS) that may be associated with salivary gland abnormalities consistent with secondary SS.Methods: Patients with SLE onset prior to age 18 were recruited. Patients completed questionnaires rating symptoms and underwent major SGUS examination. Disease and demographic differences were compared between cSLE patients with abnormal SGUS vs. cSLE patients with normal SGUS using t-tests and Fisher’s exact tests.Results: 31 cSLE patients were recruited, 84% were female, 55% were Caucasian. The average disease duration among all patients was 5 years. Average time to complete the SGUS examination and scoring protocol was 7 minutes. 35% of SGUS scores were abnormal and significantly associated with IgG level at diagnosis, and anti-Ro and anti-La antibodies.Conclusions: This is the first study to assess major SGUS in a cohort of patients with cSLE without prior diagnoses of SS. The SGUS protocol was feasible to perform by rheumatologists in a clinic setting. Although the sample size was small, SGUS abnormalities were identified in one-third of patients. IgG level at diagnosis and anti-Ro and anti-La antibodies may be associated with SGUS abnormalities.

scholarly journals Vaccination coverage in systemic lupus erythematosus—a cross-sectional analysis of the German long-term study (LuLa cohort)

Rheumatology ◽  
2018 ◽  
Vol 57 (8) ◽  
pp. 1439-1447 ◽  
Author(s):  
Gamal Chehab ◽  
Jutta G Richter ◽  
Ralph Brinks ◽  
Rebecca Fischer-Betz ◽  
Borgi Winkler-Rohlfing ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vaccination Coverage ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Term Study ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Long Term Study ◽  
Sectional Analysis

Medical adherence in patients with systemic lupus erythematosus in Germany: predictors and reasons for non-adherence – a cross-sectional analysis of the LuLa-cohort

Lupus ◽  
2018 ◽  
Vol 27 (10) ◽  
pp. 1652-1660 ◽  
Author(s):  
G Chehab ◽  
G M Sauer ◽  
J G Richter ◽  
R Brinks ◽  
R Willers ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Sufficient Information ◽  
Medical Adherence ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Long Term Study ◽  
High Adherence ◽  
Sectional Analysis

Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adherence. Our aim was to investigate the adherence to lupus-specific medications in German lupus patients and to assess influencing factors including detrimental or beneficial effects of health perceptions and beliefs. Methods The Lupus Erythematosus (LE) Long-Term Study (LuLa-study) is a nationwide longitudinal study among German Caucasian patients with systemic lupus erythematosus who have been assessed annually using a self-reported questionnaire since 2001. In 2013, we included questions concerning medical adherence (Morisky Medication Adherence Scale; MMAS-4), beliefs about medication prescribed (BMQ), illness perception and about the patients’ health locus of control (HLC). We present a cross-sectional analysis to assess predictors of adherence using a multivariable stepwise logistic regression. Results Five hundred and seventy-nine patients participated, 81 of whom did not take any lupus-specific medication and 40 of whom did not complete the MMAS-4 and were therefore omitted. Only 62.7% reported high adherence. Unintentional behaviour for low medical adherence exceeded the intentional behaviour by far. The use of azathioprine (OR: 1.85; 95% CI: 1.02–3.34), prednisone <7.5 mg (OR: 1.56; 95% CI: 0.97–2.49), a higher age (OR: 1.06; 95% CI: 1.03–1.08) and higher external HLC (OR: 1.15; 95% CI: 1.01–1.30) proved conducive for high adherence in our multivariable model. On the contrary, the general perception of medication being harmful or addictive (OR: 0.89; 95% CI: 0.82–0.97) was detrimental. Conclusion A low belief that one's own health is determined by healthcare providers (external HLC) and the belief of the harmfulness of medication were independent predictors of low adherence besides age and the choice of the medical agent. The recognition of these potential obstacles in physician–patient relationships is essential to ameliorate adherence. Provision of sufficient information and education might help to reach the best possible outcome.

scholarly journals Findings and feasibility of major salivary gland ultrasound in childhood-onset systemic lupus erythematosus: a pilot study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Joseph McDonald ◽  
Patricia Vega-Fernandez ◽  
Tracy Ting
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Salivary Gland ◽  
Lupus Erythematosus ◽  
Major Salivary Gland ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Clinic Setting ◽  
Igg Level ◽  
Onset Systemic Lupus Erythematosus

Abstract Background Childhood-onset systemic lupus erythematosus (cSLE) is a complex autoimmune disorder with multi-organ manifestations and can be associated with other rheumatic diseases including Sjögren’s syndrome (SS). Salivary gland ultrasound (SGUS) represents a noninvasive tool to screen for salivary gland disease in rheumatic disease patients. The aims of this cross-sectional study were to determine feasibility of major SGUS in a clinic setting and to identify characteristics in a cohort of cSLE patients (without confirmed SS) that may be associated with salivary gland abnormalities consistent with secondary SS. Methods Patients with SLE onset prior to age 18 were recruited. Patients completed questionnaires rating symptoms and underwent major SGUS examination. Disease and demographic differences were compared between cSLE patients with abnormal SGUS vs. cSLE patients with normal SGUS using t-tests and Fisher’s exact tests. Results Thirty-one cSLE patients were recruited, 84% were female, 55% were Caucasian. The average disease duration among all patients was 5 years. Average time to complete the SGUS examination and scoring protocol was 7 min. 35% of SGUS scores were abnormal and significantly associated with IgG level at diagnosis, and anti-Ro and anti-La antibodies. Conclusions This is one of the first studies to our knowledge that assesses major SGUS in a cohort of patients with cSLE without prior diagnoses of SS. The SGUS protocol was feasible to perform by rheumatologists in a clinic setting. Although the sample size was small, SGUS abnormalities were identified in one-third of patients. IgG level at diagnosis and anti-Ro and anti-La antibodies may be associated with SGUS abnormalities.

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