scholarly journals Correction to: Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Mark Connelly ◽  
◽  
Jennifer E. Weiss
Keyword(s):  
Rheumatic Diseases ◽  
Functional Disability ◽  
Juvenile Fibromyalgia

scholarly journals Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Mark Connelly ◽  
◽  
Jennifer E. Weiss
Keyword(s):  
Rheumatic Disease ◽  
Rheumatic Diseases ◽  
Pediatric Rheumatology ◽  
Functional Disability ◽  
Juvenile Dermatomyositis ◽  
Functional Limitations ◽  
Well Being ◽  
Effect Sizes ◽  
Juvenile Fibromyalgia ◽  
Disease Effect

Abstract Background Severe pain and impairments in functioning are commonly reported for youth with juvenile fibromyalgia. The prevalence and impact of pain in other diseases commonly managed in pediatric rheumatology comparatively have been rarely systematically studied. The objective of the current study was to determine the extent to which high levels of pain and functional limitations, and the strength of their association, are unique to youth with juvenile primary fibromyalgia syndrome/JPFS) relative to other pediatric rheumatic diseases. Methods Using data from 7753 patients enrolled in the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, we compared the levels and association of pain and functional limitations between youth with JPFS and those with other rheumatic diseases. Results Pain levels were rated highest among youth with JPFS (M = 6.4/10, SD = 2.4) and lowest for juvenile dermatomyositis (M = 1.7/10, SD = 2.2), with pain significantly higher in the JPFS group than any other pediatric rheumatic disease (effect sizes = .22 to 1.05). Ratings on measures of functioning and well-being also were significantly worse for patients with JPFS than patients with any other rheumatic disease (effect sizes = .62 to 1.06). The magnitude of association between pain intensity and functional disability, however, generally was higher in other rheumatic diseases than in JPFS. Pain was most strongly associated with functional limitations in juvenile dermatomyositis, juvenile idiopathic arthritis, and mixed connective tissue disease. Conclusions JPFS is unique among conditions seen in pediatric rheumatology with regard to ratings of pain and disability. However, pain appears to be comparably or more highly associated with level of functional impairment in other pediatric rheumatic diseases. Pain in childhood rheumatic disease thus would benefit from increased prioritization for research and treatment.

Epidermal Neurite Density in Skin Biopsies from Patients with Juvenile Fibromyalgia

2020 ◽  
pp. jrheum.200378
Author(s):  
Alexis Boneparth ◽  
Shan Chen ◽  
Daniel B. Horton ◽  
L. Nandini Moorthy ◽  
Ian Farquhar ◽  
...  
Keyword(s):  
Functional Disability ◽  
Meta Analysis ◽  
Skin Surface ◽  
Lower Leg ◽  
Healthy Controls ◽  
Juvenile Fibromyalgia ◽  
Neurite Density ◽  
American College Of Rheumatology ◽  
Small Fiber ◽  
Diagnostic Threshold

Objective Fibromyalgia is defined by idiopathic, chronic, widespread musculoskeletal pain. In adults with fibromyalgia, meta-analysis of lower-leg skin biopsy demonstrated 45% pooled prevalence of abnormally low epidermal neurite density (END). END <5th centile of the normal distribution is the consensus diagnostic threshold for small-fiber neuropathy. However, the clinical significance of END findings in fibromyalgia is unknown. The prevalence of small fiber pathology has not yet been studied in juvenile fibromyalgia. Methods We screened 21 patients aged 13-20y with fibromyalgia diagnosed by pediatric rheumatologists. Fifteen meeting the American College of Rheumatology criteria (modified for juvenile fibromyalgia) underwent lower-leg measurements of END and completed validated questionnaires assessing pain, functional disability, and dysautonomia symptoms. The primary outcome was proportion of fibromyalgia patients with END <5th centile of age/gender/race-based laboratory norms. Cases were systematically matched by ethnicity, race, sex, and age to a group of previously biopsied healthy adolescents with selection blinded to biopsy results. All 23 controls matching demographic criteria were included. Results Among biopsied JFM patients, 53% (8/15) had END <5th centile versus 4% (1/23) of healthy controls (p<0.001). Mean patient END was 273/mm2 skin surface (95% confidence interval: 198-389) versus 413 (95% CI: 359-467; p<0.001). As expected, fibromyalgia patients reported more functional disability, dysautonomia, and pain than healthy controls. Conclusion Abnormal END reduction is common in adolescents with fibromyalgia, with similar prevalence to adults with fibromyalgia. More studies are needed to fully characterize the significance of low END in fibromyalgia and to elucidate the clinical implications of these findings.

Trends in Treatment, Outcomes, and Incidence of Orthopedic Surgery in Patients with Rheumatoid Arthritis: An Observational Cohort Study Using the Japanese National Database of Rheumatic Diseases

2017 ◽  
Vol 44 (11) ◽  
pp. 1575-1582 ◽  
Author(s):  
Takumi Matsumoto ◽  
Jinju Nishino ◽  
Naohiro Izawa ◽  
Masashi Naito ◽  
Jun Hirose ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Outcome ◽  
Rheumatic Diseases ◽  
Orthopedic Surgery ◽  
Functional Disability ◽  
Supply And Demand ◽  
Linear Regression Analysis ◽  
National Database ◽  
Orthopedic Procedures ◽  
Annual Data

Objective.In this study, we investigated the changes in clinical outcome, treatment, and incidence of orthopedic surgery in patients with rheumatoid arthritis (RA) from 2004 to 2014.Methods.Data were studied from the Japanese nationwide cohort database, NinJa (National Database of Rheumatic Diseases by iR-net in Japan), from 2004 to 2014. The time trends in the incidence of orthopedic procedures were analyzed using linear regression analysis. The cross-sectional annual data were compared between 2004 and 2014 to analyze the changes in clinical outcome and treatment.Results.The incidence of orthopedic surgeries in patients with RA consistently decreased from 72.2 procedures per 1000 patients in 2004 to 51.5 procedures per 1000 patients in 2014 (regression coefficient = −0.0028, 95% CI −0.0038 to −0.0019, p < 0.001). The greatest reduction was found in total knee arthroplasty and total hip arthroplasty. Disease activity and functional disability improved significantly over this decade. The proportions of patients receiving methotrexate and biologic disease-modifying antirheumatic drugs significantly increased from 39.6% and 1.7% in 2004 to 63.8% and 27.4% in 2014, respectively.Conclusion.The overall incidence of orthopedic surgeries in patients with RA significantly decreased, accompanied by improved clinical outcomes because of the expanded use of effective drugs; however, the declining trend differed between procedures or locations. The results from the present study suggest that there might be a change in supply and demand for orthopedic surgeries.

Obstetrics and pregnancy

2013 ◽  
Author(s):  
Monika Østensen ◽  
Radboud Dolhain ◽  
Guillermo Ruiz-Irastorza
Keyword(s):  
Rheumatic Disease ◽  
Pregnancy Outcome ◽  
Rheumatic Diseases ◽  
Functional Disability ◽  
Fetal Outcome ◽  
Disease Symptoms ◽  
Spontaneous Improvement ◽  
Maternal Disease

Rheumatic diseases occur preferentially in women, often during their childbearing years. Most women with rheumatic disease wish to have children, even when functional disability is present. Better therapy and better prognosis for many of the rheumatic diseases has resulted in more patients considering pregnancy. The interaction of pregnancy and the rheumatic diseases is varied, ranging from spontaneous improvement to aggravation, sometimes severe, of disease symptoms. Likewise, rheumatic diseases differ with regard to the occurrence of complications during pregnancy, and pregnancy outcome. This chapter describes fertility, the course of maternal disease during pregnancy, and fetal outcome.

Obstetrics and pregnancy

2013 ◽  
pp. 121-126
Author(s):  
Monika Østensen ◽  
Radboud Dolhain ◽  
Guillermo Ruiz-Irastorza
Keyword(s):  
Rheumatic Disease ◽  
Pregnancy Outcome ◽  
Rheumatic Diseases ◽  
Functional Disability ◽  
Fetal Outcome ◽  
Disease Symptoms ◽  
Spontaneous Improvement ◽  
Maternal Disease

Rheumatic diseases occur mostly in women, often during their childbearing years. Most women with rheumatic disease wish to have children, even when functional disability is present. Better therapy and better prognosis for many of the rheumatic diseases has resulted in more patients considering pregnancy. The interaction of pregnancy and rheumatic diseases is varied, ranging from spontaneous improvement to aggravation, sometimes severe, of disease symptoms. Likewise, rheumatic diseases differ with regard to the occurrence of complications during pregnancy, and pregnancy outcome. This chapter describes fertility, the course of maternal disease during pregnancy, and fetal outcome.

scholarly journals Laboratory Interpretation of Rheumatic Diseases

2021 ◽  
pp. 67-81
Author(s):  
Altaf Abdulkhaliq ◽  
Manal Alotaibi
Keyword(s):  
Early Diagnosis ◽  
Rheumatic Diseases ◽  
Functional Disability ◽  
Effective Therapy ◽  
Disease Outcome ◽  
Disease Specific

AbstractGenerally the diagnosis of rheumatic diseases is based on a set of clinical, serological, and radiological measures. The discovery of a novel test that appears to be considerably more disease-specific and preferably sensitive would be of value for the early diagnosis and immediate, effective therapy to prevent joint deterioration, functional disability, and unfavorable disease outcome [1].

Sign in / Sign up

Export Citation Format

Share Document