scholarly journals Two cases of relapsed HIV-associated visceral leishmaniasis successfully treated with combination therapy

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Antonio Mastroianni ◽  
Paolo Gaibani ◽  
Giada Rossini ◽  
Caterina Vocale ◽  
Maria Carla Re ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Combination Therapy

scholarly journals Combination therapy for visceral leishmaniasis

2013 ◽  
Vol 2 (2) ◽  
pp. 32-33 ◽  
Author(s):  
MR Banjara
Keyword(s):  
Visceral Leishmaniasis ◽  
Combination Therapy

DOI: http://dx.doi.org/10.3126/ijim.v2i2.8318Int J Infect Microbiol 2013;2(2):32-33 

scholarly journals Combination Therapy with Paromomycin-Associated Stearylamine-Bearing Liposomes Cures Experimental Visceral Leishmaniasis through Th1-Biased Immunomodulation

2011 ◽  
Vol 55 (4) ◽  
pp. 1661-1670 ◽  
Author(s):  
Antara Banerjee ◽  
Manjarika De ◽  
Nahid Ali
Keyword(s):  
Visceral Leishmaniasis ◽  
Combination Therapy ◽  
Low Dose ◽  
Transforming Growth Factor ◽  
Prolonged Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Single Shot ◽  
Synergistic Activity ◽  
Combination Drug ◽  
Promising Alternative

ABSTRACTVisceral leishmaniasis (VL) caused by the parasiteLeishmania donovaniis a potentially fatal disease. Available limited drugs are toxic, require prolonged treatment duration, and are costly. A low-cost parenteral formulation of paromomycin sulfate (PM) has recently been approved for the treatment of VL. Monotherapy with PM runs the risk of development of resistance. Hence, efforts are needed to develop a combination therapy of PM with other drugs to shorten the duration of treatment and prolong the effective life of the drug. PM was formulated with leishmanicidal stearylamine (SA)-bearing phosphatidylcholine (PC) liposomes for low-dose therapy.In vitroandin vivoantileishmanial effects of the combination drug were determined. The immunomodulatory role of PC-SA-PM was determined using enzyme-linked immunosorbent assay (ELISA) and flow cytometry. Excluding the spleen, for which the therapeutic effect was additive, a remarkable synergistic activity toward cure and prophylaxis with a single-shot low-dose treatment with PC-SA-associated PM was achieved with BALB/c mice. PC-SA-PM showed an immunomodulatory effect on CD4+and CD8+T cells for gamma interferon (IFN-γ) production and downregulated disease-associated interleukin-10 (IL-10) and transforming growth factor β (TGF-β) to almost negligible levels. Such combination chemotherapy may provide a promising alternative for the cure of leishmaniasis, with a plausible conversion of the host immune response from a disease-promoting pattern to a Th1-biased response indicative of long-term resistance.

scholarly journals TLR9 and MyD88 are crucial for the maturation and activation of dendritic cells by paromomycin-miltefosine combination therapy in visceral leishmaniasis

2014 ◽  
Vol 171 (5) ◽  
pp. 1260-1274 ◽  
Author(s):  
Sushmita Das ◽  
Mukta Rani ◽  
Vidyanand Rabidas ◽  
Krishna Pandey ◽  
Ganesh Chandra Sahoo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Visceral Leishmaniasis ◽  
Combination Therapy

Combination therapy for visceral leishmaniasis

2010 ◽  
Vol 10 (3) ◽  
pp. 184-194 ◽  
Author(s):  
Johan van Griensven ◽  
Manica Balasegaram ◽  
Filip Meheus ◽  
Jorge Alvar ◽  
Lutgarde Lynen ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Combination Therapy

A rare case of Visceral leishmaniasis with multiple relapse and multi-drug unresponsive: successfully treated with combination therapy

2011 ◽  
Vol 33 (5) ◽  
pp. 726-729 ◽  
Author(s):  
Nawin Kumar ◽  
Prabhat Kumar Sinha ◽  
Krishna Pandey ◽  
Neena Verma ◽  
Chandra Shekhar Lal ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Combination Therapy ◽  
Rare Case ◽  
Multiple Relapse

scholarly journals Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case

2018 ◽  
Vol 51 (3) ◽  
pp. 393-396 ◽  
Author(s):  
Maria Antonia Ferreira Gomes ◽  
Lana Lira Cantidio de Medeiros ◽  
Fernanda Paula Dantas Lobo ◽  
Nathália Rayane Silva Wanderley ◽  
Ana Paula Rodrigues Matos ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Combination Therapy ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Pentamidine Isethionate ◽  
Visceral Leishmaniasis Case
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