A new series of indole-based pyranoquinoline derivatives
P
1–24
has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl-
N
-allyl-indole-3-carbaldehydes
1a–d
; active methylenes
2a–c
; and 4-hydroxy-1-substituted quinolin-2(1
H
)-one
3a–b
catalysed by an organocatalyst tetra-
n
-butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.
A facile and efficient synthesis of 1,8-dioxodecahydroacridines derivatives catalyzed by cobalt–alanine metal complex under aqueous ethanol media
