Poly(4-amino-3-hydroxynaphthalene-1-sulfonic acid) modified glassy carbon electrode for square wave voltammetric determination of amoxicillin in four tablet brands

Abstract Background Amoxicillin (AMX), which is one of the β-lactam antibiotics used in the treatment of bacterial infections, is known to have a serious mechanism of resistance necessitating continuous monitoring of its level in pharmaceutical and serum samples. Results In this study, we presented selective, accurate, and precise square wave voltammetric method based on poly(4-amino-3-hydroxynaphthalene-1-sulfonic acid) modified glassy carbon electrode (poly(AHNSA/GCE)) for determination of amoxicillin in four selected tablet brands. Appearance of a peak in the oxidative scan direction without a peak in the reductive direction of cyclic voltammograms of both bare GCE and poly(AHNSA/GCE) with four folds current and much reduced potential on the modified electrode showed catalytic property of the modifier towards oxidation of AMX. While cyclic voltammetric studies of effect of scan rate showed predominantly diffusion controlled oxidation of AMX with one electron participation, effect of pH revealed participation of protons and electrons in a 1:1 ratio. The square wave voltammetric peak current response of the modified electrode for AMX showed linear dependence on the concentration of the spiked standard AMX in the range 10–150 µmol L−1 with 9.9 nmol L−1 LOD. The AMX content of the studied tablet brands were found in the range 97.84–100.78% of the labeled value. Spike recovery results of 99.6–100.5%, and interference recovery results of 95.4–100.8% AMX in the presence of 50–200% of ampicillin and cloxicillin validated the applicability of the method for determination of amoxicillin in tablet formulation. Conclusion In contrast to the previously reported works on determination of amoxicillin, the present method showed an excellent performance making it a potential method for determination of amoxicillin in real samples including serum samples.

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Simultaneous determination of caffeine and paracetamol by square wave voltammetry at poly(4-amino-3-hydroxynaphthalene sulfonic acid)-modified glassy carbon electrode

Food Chemistry ◽

10.1016/j.foodchem.2016.04.106 ◽

2016 ◽

Vol 210 ◽

pp. 156-162 ◽

Cited By ~ 55

Author(s):

Molla Tefera ◽

Alemnew Geto ◽

Merid Tessema ◽

Shimelis Admassie

Keyword(s):

Simultaneous Determination ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Sulfonic Acid ◽

Square Wave Voltammetry ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Square Wave ◽

Wave Voltammetry

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Electrochemical Determination of Trace Pb (II) by The Modified Glassy Carbon Electrode Compositing MultiWalled Carbon Nanotubes-Nafion-Bi Film

Journal of Electronics and Sensors ◽

10.31829/2689-6958/jes2020-3(1)-108 ◽

2020 ◽

pp. 1-12

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Modified Electrode ◽

Glassy Carbon ◽

Anodic Stripping Voltammetry ◽

Electrochemical Sensing ◽

Carbon Electrode ◽

Bismuth Film ◽

Modified Glassy Carbon Electrode

A modified glassy carbon electrode (GCE) compositing multi-walled carbon nanotubes (MWCNTs), Nafion and bismuth film was prepared and applied for the sensitive detection of trace Pb (II). MWCNTs were dispersed into ethanol by ultrasonication in the presence of Nafion and the nanotubes are coated onto the bare GCE. After that, an extra Nafion adhesion agent is added to the electrode. By the in situ plating, a bismuth film was fabricated on the MWCNTs-NA/GCE, making the desired electrode, MWCNTs-NA-Bi/GCE. The modified electrode was characterized by differential pulse anodic stripping voltammetry, scanning electron microscopy, and cyclic voltammetry. A deposition potential of –1.4 V (vs. Ag/AgCl) and a deposition time of 300 s were applied to the working electrode under stirred conditions after optimizing. Nanotubes and Nafion concentrations and pH were carefully optimized to determine trace lead ions by using the electrode as an electrochemical-sensing platform. Nafion effectively increased the stability and adhesivity of the composite film. The MWCNTs-NA-Bi film modified electrode can remarkably increase the anodic peak current of Pb2+. The sensitivity of MWCNTs-NA-Bi/GCE is 4.35 times higher than that of the bare GCE with bismuth film. The prepared electrode showed excellent stability and reproducibility and can be applied for determination of Pb2+ contained wastewater.

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Simultaneous determination of TBHQ and BHA on a MWNT-Brij® 35 modified electrode in micellar media

Analytical Methods ◽

10.1039/c5ay01973g ◽

2015 ◽

Vol 7 (19) ◽

pp. 8344-8351 ◽

Cited By ~ 6

Author(s):

Guzel Ziyatdinova ◽

Karina Os'kina ◽

Endzhe Ziganshina ◽

Herman Budnikov

Keyword(s):

Simultaneous Determination ◽

Glassy Carbon Electrode ◽

Modified Electrode ◽

Glassy Carbon ◽

Carbon Electrode ◽

Micellar Medium ◽

Micellar Media ◽

Modified Glassy Carbon Electrode ◽

Simultaneous Voltammetric Determination

Simultaneous voltammetric determination of TBHQ and BHA using a MWNT-Brij® 35 modified glassy carbon electrode in Brij® 35 micellar medium.

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Electrocatalytic Response and Determination of Noradrenaline in the Presence of L-Ascorbic and Uric Acids with Poly(Eriochrome Black T)-Modified Electrode

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc20071177 ◽

2007 ◽

Vol 72 (9) ◽

pp. 1177-1188 ◽

Cited By ~ 7

Author(s):

Xinhua Lin ◽

Wei Li ◽

Hong Yao ◽

Yuanyuan Sun ◽

Liying Huang ◽

...

Keyword(s):

Glassy Carbon Electrode ◽

Modified Electrode ◽

Glassy Carbon ◽

Dynamic Range ◽

Differential Pulse ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Eriochrome Black T ◽

Wide Linear Dynamic Range

A poly(Eriochrome Black T) chemically modified glassy carbon electrode modified with Eriochrome Black T was prepared by cyclic voltammetry. The modified electrode showed an excellent electrocatalytic activity in oxidation of noradrenaline (NA) and could separate its electrochemical responses from those of L-ascorbic acid (AA) and uric acid (UA). Differences of the oxidation peak potentials for NA-AA and UA-NA were about 150 mV. The responses to NA, AA and UA of the modified electrode are relatively independent. Using differential pulse voltammetry, the peak currents of NA at modified glassy carbon electrode increased linearly with the concentration of NA from 0.5 to 100 μmol l-1. The detection limit was 0.2 μmol l-1. With the modified electrode, UA could be selectively determined in the presence of AA. The method showing a wide linear dynamic range and excellent sensitivity was successfully applied to the determination of NA in pharmaceutical injections and various samples.

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Sensitive determination of phenylephrine and chlorprothixene at poly(4-aminobenzene sulfonic acid) modified glassy carbon electrode

Talanta ◽

10.1016/j.talanta.2007.09.018 ◽

2008 ◽

Vol 74 (5) ◽

pp. 1435-1441 ◽

Cited By ~ 23

Author(s):

Fei Huang ◽

Guiying Jin ◽

Yang Liu ◽

Jilie Kong

Keyword(s):

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Sulfonic Acid ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Sensitive Determination

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A voltammetric sensor based on eosin Y film modified glassy carbon electrode for simultaneous determination of hydroquinone and catechol

Analytical Methods ◽

10.1039/c4ay00575a ◽

2014 ◽

Vol 6 (16) ◽

pp. 6494-6503 ◽

Cited By ~ 23

Author(s):

Jiahong He ◽

Ri Qiu ◽

Wenpo Li ◽

Shaohua Xing ◽

Zhongrong Song ◽

...

Keyword(s):

Cyclic Voltammetry ◽

Simultaneous Determination ◽

Glassy Carbon Electrode ◽

Modified Electrode ◽

Glassy Carbon ◽

Eosin Y ◽

Carbon Electrode ◽

Voltammetric Sensor ◽

Modified Glassy Carbon Electrode

By using cyclic voltammetry, eosin Y film was electrodeposited on the surface of glassy carbon electrode (GCE) to obtain the modified electrode (denoted as eosin Y/GCE).

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Square wave voltammetric determination of quercetin in wine and fruit juice samples at poly (safranine O) modified glassy carbon electrode

Sensing and Bio-Sensing Research ◽

10.1016/j.sbsr.2021.100466 ◽

2021 ◽

pp. 100466

Author(s):

Gizaw Tesfaye ◽

Merid Tessema ◽

Negussie Negash ◽

Tesfu Hailu

Keyword(s):

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Fruit Juice ◽

Voltammetric Determination ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Square Wave ◽

Safranine O

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Electroanalytical analysis of guaifenesin on poly(acridine orange) modified glassy carbon electrode and its determination in pharmaceuticals and serum samples

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200709170450 ◽

2020 ◽

Vol 23 ◽

Author(s):

Hasan Işik ◽

Gökçe Öztürk ◽

Fatma Ağin ◽

Dilek Kul

Keyword(s):

Human Serum ◽

Acridine Orange ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Supporting Electrolyte ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Serum Samples ◽

Human Serum Samples

Background: Electroanalytical methods are very functional to detect drugs in pharmaceuticals (tablets, syrups, suppositories, creams and ointments) and biological samples. Objective: In this study, it is aimed to make selective, sensitive, simple, fast and low cost electrochemical analysis of expectorant drug guaifenesin in pharmaceuticals and serum samples. Method: Differential pulse adsorptive stripping voltammetric method for determination of guaifenesin on a poly(acridine orange) modified glassy carbon electrode has been developed. Glassy carbon electrode was modified with electropolymerization of acridine orange monomer for sensitive determination of guaifenesin. Guaifenesin provided highly reproducible and well-defined irreversible oxidation peaks at +1.125 V and +1.128 V (vs. Ag/AgCl) in the selected supporting electrolyte and human serum samples, respectively. Results: Under optimized conditions, linear response of peak current on the concentration of guaifenesin has been obtained in the ranges of 2.00×10-7 to 1.00×10-4 M in Britton Robinson buffer solution at pH 7.0 and 4.00×10-7 to 1.00×10-4 M in serum samples. The precision of the method was detected by intraday and inter-day repeatability studies in the supporting electrolyte and serum samples media. Conclusion: The analytical applicability of the proposed method exhibited satisfying determination results for guaifenesin from pharmaceutical dosage forms (syrup) and human serum samples without any pre-separation procedure.

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A Novel Silver-Doped Poly(p-aminobenzene sulfonic acid) Modified Glassy Carbon Electrode for Analysis of H2O2

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.600.133 ◽

2012 ◽

Vol 600 ◽

pp. 133-136

Author(s):

De Ling Chi ◽

Kai Zhao ◽

Zheng Xiao Liu ◽

Fei Fei Zhang ◽

Zong Hua Wang

Keyword(s):

Glassy Carbon Electrode ◽

Modified Electrode ◽

Glassy Carbon ◽

Sulfonic Acid ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Electrochemical Behaviors

A novel silver-doped poly (p-aminobenzene sulfonic acid) modified electrode was fabricated, of which the electrochemical behaviors were studied with H2O2as a probe. In pH 7.0 PBS, a sensitive reductive peak of H2O2was observed. The modified electrode is of potential in practice for analysis of H2O2in samples such as milk.

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