Electroanalytical analysis of guaifenesin on poly(acridine orange) modified glassy carbon electrode and its determination in pharmaceuticals and serum samples

2020 ◽  
Vol 23 ◽  
Author(s):  
Hasan Işik ◽  
Gökçe Öztürk ◽  
Fatma Ağin ◽  
Dilek Kul
Keyword(s):  
Human Serum ◽  
Acridine Orange ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Supporting Electrolyte ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Human Serum Samples

Background: Electroanalytical methods are very functional to detect drugs in pharmaceuticals (tablets, syrups, suppositories, creams and ointments) and biological samples. Objective: In this study, it is aimed to make selective, sensitive, simple, fast and low cost electrochemical analysis of expectorant drug guaifenesin in pharmaceuticals and serum samples. Method: Differential pulse adsorptive stripping voltammetric method for determination of guaifenesin on a poly(acridine orange) modified glassy carbon electrode has been developed. Glassy carbon electrode was modified with electropolymerization of acridine orange monomer for sensitive determination of guaifenesin. Guaifenesin provided highly reproducible and well-defined irreversible oxidation peaks at +1.125 V and +1.128 V (vs. Ag/AgCl) in the selected supporting electrolyte and human serum samples, respectively. Results: Under optimized conditions, linear response of peak current on the concentration of guaifenesin has been obtained in the ranges of 2.00×10-7 to 1.00×10-4 M in Britton Robinson buffer solution at pH 7.0 and 4.00×10-7 to 1.00×10-4 M in serum samples. The precision of the method was detected by intraday and inter-day repeatability studies in the supporting electrolyte and serum samples media. Conclusion: The analytical applicability of the proposed method exhibited satisfying determination results for guaifenesin from pharmaceutical dosage forms (syrup) and human serum samples without any pre-separation procedure.

scholarly journals Electrochemical Determination of Furosemide Drug at Tranexamic Acid Gold Nanoparticles Modified Glassy Carbon Electrode

2021 ◽  
Vol 22 (1) ◽  
pp. 172-179
Author(s):  
Tasawar Ali Chandio
Keyword(s):  
Gold Nanoparticles ◽  
Tranexamic Acid ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Supporting Electrolyte ◽  
Electrochemical Determination ◽  
Calibration Plot ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode

The reported work discussed the simpler and sensitive strategy for the electrochemical determination of furosemide by employed tranexamic acid derived gold nanoparticles modified glassy carbon electrode (GCE). The synthesis of tranexamic acid derived gold nanoparticles (Tr- AuNps) was carried out using single step approach. The synthesized Tr-AuNps were characterized by using atomic force microscopy (AFM), illustrated that the particles are spherical in shape with an average size of 35 nm. The synthesized AuNps have modified the sensing surface of GCE. The modified GCE demonstrated highly catalytic behavior for the oxidation of loop diuretic drug furosemide. The influence of pH and supporting electrolyte was examined and the working conditions were optimized. The amperometric determination of furosemide was also carried out at the Tr-AuNps modified GCE under stirred conditions using Britton Robinson buffer (BR buffer) as supporting electrolyte at pH 5. The linear calibration plot showed the dependence of the peak current on increasing concentrations of furosemide in the range of 50 μM to 500 μM furosemide with the detection limit of 5 μM. The proposed sensing plan has been successfully employed for the quantification of furosemide in human urine samples with satisfactory recoveries.

scholarly journals Poly(4-amino-3-hydroxynaphthalene-1-sulfonic acid) modified glassy carbon electrode for square wave voltammetric determination of amoxicillin in four tablet brands

BMC Chemistry ◽  
2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Adane Kassa ◽  
Meareg Amare
Keyword(s):  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Sulfonic Acid ◽  
Current Response ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Square Wave

Abstract Background Amoxicillin (AMX), which is one of the β-lactam antibiotics used in the treatment of bacterial infections, is known to have a serious mechanism of resistance necessitating continuous monitoring of its level in pharmaceutical and serum samples. Results In this study, we presented selective, accurate, and precise square wave voltammetric method based on poly(4-amino-3-hydroxynaphthalene-1-sulfonic acid) modified glassy carbon electrode (poly(AHNSA/GCE)) for determination of amoxicillin in four selected tablet brands. Appearance of a peak in the oxidative scan direction without a peak in the reductive direction of cyclic voltammograms of both bare GCE and poly(AHNSA/GCE) with four folds current and much reduced potential on the modified electrode showed catalytic property of the modifier towards oxidation of AMX. While cyclic voltammetric studies of effect of scan rate showed predominantly diffusion controlled oxidation of AMX with one electron participation, effect of pH revealed participation of protons and electrons in a 1:1 ratio. The square wave voltammetric peak current response of the modified electrode for AMX showed linear dependence on the concentration of the spiked standard AMX in the range 10–150 µmol L−1 with 9.9 nmol L−1 LOD. The AMX content of the studied tablet brands were found in the range 97.84–100.78% of the labeled value. Spike recovery results of 99.6–100.5%, and interference recovery results of 95.4–100.8% AMX in the presence of 50–200% of ampicillin and cloxicillin validated the applicability of the method for determination of amoxicillin in tablet formulation. Conclusion In contrast to the previously reported works on determination of amoxicillin, the present method showed an excellent performance making it a potential method for determination of amoxicillin in real samples including serum samples.

Electrochemical studies of ascorbic acid, dopamine, and uric acid at a dl-norvaline-deposited glassy carbon electrode

2014 ◽  
Vol 92 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Mahmoud Mohamed Kamel ◽  
Ehab Mahmoud Abdalla ◽  
Mohamed Sayed Ibrahim ◽  
Yassin Mohamed Temerk
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Solution Ph

The electrochemical behavior of ascorbic acid (AA), dopamine (DA), and uric acid (UA) on a dl-norvaline-modified glassy carbon electrode (GCE) was studied by cyclic voltammetry. The bare GCE failed to distinguish the oxidation peaks of AA, DA, and UA in phosphate-buffered solution (pH 5.0), while the dl-norvaline-modified GCE could separate them efficiently. In differential pulse voltammetric (DPV) measurements, the modified electrode resolved the overlapped voltammetric responses of AA, DA, and UA into three well-defined voltammetric peaks. Under optimum conditions, the anodic peak currents of DPV for AA, DA, and UA were proportional to the concentration in the range of 20–400, 1–40, and 15–180 μmol/L, respectively, with a correlation coefficient (r) of around 0.998. The detection limits were 5, 0.3, and 10 μmol/L (S/N = 3) for AA, DA, and UA, respectively. Satisfactory results were achieved for the determination of AA in vitamin C tablets, DA in a dopamine ampoule sample, and UA in human blood serum samples.

Determination of diltiazem in the presence of timolol in human serum samples using a nanoFe3O4@GO modified glassy carbon electrode

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51734-51744 ◽  
Author(s):  
Mohammad Hasanzadeh ◽  
Mohammad Hossein Pournaghi-Azar ◽  
Nasrin Shadjou ◽  
Abolghasem Jouyban
Keyword(s):  
Graphene Oxide ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Chemically Modified Electrode ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Magnetic Graphene Oxide ◽  
Chemically Modified

A new chemically modified electrode was constructed based on a magnetic graphene oxide modified glassy carbon electrode (nanoFe3O4@GO-GC).

scholarly journals Voltammetric determination of dopamine using modified glassy carbon electrode by electrografting of catechol

2017 ◽  
Vol 82 (9) ◽  
pp. 1053-1061 ◽  
Author(s):  
Zeinab Pourghobadi ◽  
Davood Neamatollahi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Diagnostic Technique ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Linear Calibration ◽  
Serum Samples ◽  
Relative Standard ◽  
Replicate Measurements

By means of cyclic voltammetry as a diagnostic technique, the present study tried to describe the behaviour of dopamine (DP) at the bare and catechol electrografted glassy carbon electrode (CA/GCE). The results indicated that the CA/GCE exhibits high electrocatalytic activity toward DP. The DP cycling of the CA/GCE in DP showed two linear calibration ranges between 5.0?100 and 100?750 ?M with a detection limit of 0.86 ?M. For 6 DP replicate measurements (50 ?M); the relative standard deviation (RSD) was 2.7 %. This method was successfully used for the determination of DP in serum samples.

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