scholarly journals Extraction socket grafting using recombinant human bone morphogenetic protein-2-clinical implications and histological observations

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Khushboo Jeevan Durge ◽  
Vidya Sudhindra Baliga ◽  
Shilpa Bangalore Sridhar ◽  
Prasad Vijayrao Dhadse ◽  
Gayatri Chandrakant Ragit
Keyword(s):  
Bone Morphogenetic Protein ◽  
Tooth Extraction ◽  
De Novo ◽  
Bone Morphogenetic Protein 2 ◽  
Key Indicator ◽  
Implant Placement ◽  
Beta Tricalcium Phosphate ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Bone Particles

Abstract Objectives Rehabilitation of edentulous ridges to promote the insertion of dental implants has been the key indicator for retaining osseous structures since tooth extraction. Recombinant Bone Morphogenetic Protein-2(rhBMP-2) is exploited for bone augmentation due to its osteoinductive capacity. The objective of the study to determine the effectiveness of bone induction for implant placement by rhBMP-2 delivered on beta-tricalcium phosphate graft (β-TCP) and PRF following tooth extraction. Results Minimal changes in the width of the crestal bone relative to baseline values were found three months after socket grafting. A bone loss in the mesiodistal and buccolingual aspects of 0.6 ± 0.13 mm and 0.5 ± 0.13 mm was found, respectively. While drilling before the implant placement, the bone's clinical hardness evaluated through tactile was analogous to drilling into spruce or white pine wood. Total radiographic bone filling was seen in 3 months and no additional augmentation was needed during implant placement. Besides, histology shows no residual graft of bone particles. Therefore, the data from this study demonstrated that the novel combination of rhBMP-2 + β-TCP mixed with PRF has an effect on de novo bone formation and can be recommended for socket grafting before implant placement.

scholarly journals Extraction socket grafting using  Recombinant human bone morphogenetic protein-2 -Clinical implications and histological observations.

2020 ◽  
Author(s):  
Khushboo Jeevan Durge ◽  
Vidya Sudhindra Baliga ◽  
Shilpa Banglore Srid ◽  
Prasad Vijayrao Dhadse ◽  
Gayatri Chandrakant Ragit
Keyword(s):  
Bone Morphogenetic Protein ◽  
Tooth Extraction ◽  
De Novo ◽  
Bone Morphogenetic Protein 2 ◽  
White Pine ◽  
Implant Placement ◽  
Beta Tricalcium Phosphate ◽  
Bone Width ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein

Abstract Objectives –The main indication for preserving osseous structures following tooth extraction has been the rehabilitation of edentulous ridges to facilitate the placement of dental implants. Recombinant Bone Morphogenetic Protein-2(rhBMP-2) is exploited for bone augmentation due to its osteoinductive capacity. This study aimed to determine the effectiveness of bone induction for implant placement by rhBMP-2 delivered on beta-tricalcium phosphate graft (β-TCP) and PRF following tooth extraction.Results- At three months following socket grafting, minimal changes in the crestal bone width compared to baseline values were seen. A bone loss of 0.6 ± 0.13 mm and 0.5 ± 0.13 mm at the mesiodistal and buccolingual aspects, respectively, was seen. While drilling before the implant placement, the bone's clinical hardness evaluated through tactile was analogous to drilling into spruce or white pine wood. Complete radiographic bone fill was seen in 3 months, and there was no need for any additional augmentation during implant placement. Besides, histology revealed no residual bone particulate graft. Therefore, the data from this study demonstrated that the novel combination of rhBMP-2 +β-TCP mixed with PRF has an effect on de novo bone formation and can be recommended for socket grafting before implant placement.

scholarly journals Recombinant human bone morphogenetic protein -2 in combination with β-Tricalcium Phosphate and Platelet Rich Fibrin for Socket Preservation before Implant Placement

2020 ◽  
Author(s):  
Khushboo Jeevan Durge ◽  
Vidya Sudhindra Baliga ◽  
Shilpa Banglore Srid ◽  
Prasad Vijayrao Dhadse ◽  
Gayatri Chandrakant Ragit
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
White Pine ◽  
Socket Preservation ◽  
Implant Placement ◽  
Morphogenetic Protein ◽  
Bone Changes ◽  
Human Bone Morphogenetic Protein ◽  
Distal Aspect

Abstract Objectives –Periosteum is a rich source of osteoprogenitor cells, and flapless extraction technique allows for preservation of periosteum. Recombinant Bone Morphogenetic Protein-2 has osteoinductive capacity and has been exploited for bone augmentation. The aim of this study is to determine the effectiveness of rhBMP-2 for socket preservation along with β-TCP and PRF to enhance bone quality, clinically and radiographically.Results- Minimal crestal bone changes were seen at 3 months compared to baseline values; bone loss of 0.6 ± 0.13 mm at mesio-distal aspect, 0.5 ± 0.13 mm at bucco-lingual aspect. At 3 months reentry, no residual bone particulate graft were seen in any of site. Clinical hardness of bone evaluated through tactile perception while drilling, prior to implant placement, was analogous to drilling into spruce or white pine wood. Histologic analysis confirmed the absence of residual bone graft indicating new bone formation .Complete radiographic fill was seen at 3 months. The patients in current study showed adequate bone formation in grafted sockets and required no additional augmentation during implant placement. Therefore, based on the results and within the limitations of study it can be suggested that, rhBMP-2 with PRF and β-TCP can be recommended for socket preservation prior to implant placement

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