scholarly journals Concurrent myasthenia gravis-related cervical thymoma in a patient with diffuse large B-cell lymphoma: a case report 

2022 ◽  
Vol 16 (1) ◽  
Author(s):  
Chutima Kunacheewa ◽  
Sattawut Wongwiangjunt ◽  
Sanya Sukpanichnant
Keyword(s):  
Myasthenia Gravis ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Neck Mass ◽  
Pathological Examination ◽  
Large B Cell Lymphoma ◽  
Patient Reported ◽  
Pathology Review ◽  
Large B Cell

Abstract Background Cervical thymoma is a rare thymic epithelial neoplasm. Evidence supports an increased risk of second primary malignancies in patients with thymoma. We report a rare case of a patient with synchronous cervical thymoma and diffuse large B-cell lymphoma. Case presentation An 81-year-old Thai woman was referred for further treatment of diffuse large B-cell lymphoma at Siriraj Hospital, Bangkok, Thailand. While waiting for a review of the original pathological examination of a mass in the left neck and a mass in the left arm, the attending physician noticed ptosis of the upper eyelids, which was proven to be caused by myasthenia gravis. The final pathology review confirmed that the arm mass was diffuse large B-cell lymphoma, but the neck mass was cervical thymoma, type B1, not diffuse large B-cell lymphoma. Interestingly, the patient reported that the arm mass had been present for 2 years, while the neck mass had grown rapidly in the past month. A diagnostic challenge had arisen when the initial morphological evaluation was not performed with care, causing the first pathologist to misinterpret that the neoplastic cells in both masses were the same. Conclusion Concurrent cervical thymoma and diffuse large B-cell lymphoma were proven after a careful pathology review, leading to better clinical management.

scholarly journals Iris metastasis of diffuse large B-cell lymphoma misdiagnosed as primary angle-closure glaucoma: A case report and review of the literature

2021 ◽  
Vol 16 (1) ◽  
pp. 61-68
Author(s):  
Zebing Li ◽  
Zhongjing Lin ◽  
Yisheng Zhong ◽  
Xi Shen
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Therapeutic Option ◽  
B Cell Lymphoma ◽  
Angle Closure ◽  
Pathological Examination ◽  
Iris Metastasis ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Background Lymphoma with intraocular metastasis is an uncommon and serious disease. We describe a case of diffuse large B-cell lymphoma (DLBCL) with iris metastasis. Meanwhile, we refer to published case reports retrieved via a PubMed search to summarize this rare disease. Case presentation Glaucoma and uveitis symptoms were found in the left eye of a 50-year-old woman upon admission to the hospital. After treatment and pathological examination, the iris of her left eye was diagnosed with DLBCL. Given the patient’s unfavorable treatment options in the local hospital, primary enucleation was offered as a therapeutic option. Conclusions Iris metastasis of systemic lymphoma is an extremely rare ophthalmic disease with poor prognosis. Ophthalmologists should be able to definitively and differentially diagnose eye symptoms and pay attention to systemic conditions to provide a series of optimized treatments.

scholarly journals SUN-475 Thyroid Extranodal Diffuse Large B-Cell Lymphoma in Setting of Gastric Large B-Cell Lymphoma

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Yan Russell ◽  
Benjamin Schwartz ◽  
Ana Ventura ◽  
Mihaela Oprea ◽  
Jatinder Khokhar ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Neck Mass ◽  
Thyroid Function Tests ◽  
Antibody Treatment ◽  
Large B Cell Lymphoma ◽  
Pet Ct ◽  
H Pylori ◽  
Large B Cell

Abstract Background: We report a case of concomitant thyroid and gastric diffuse large B-cell lymphoma (DLBCL). Clinical Case: A 73 year-old man presented with melena of 2 days duration. EGD revealed a 1.5 x 0.7 cm gastric ulcer. Biopsy revealed marked chronic active gastritis with glandular atypia, positive for H. pylori. Repeat biopsy of the same ulcer post H. pylori treatment demonstrated high-grade B-cell lymphoma. Immunostains were positive for CD20, CD10, BCL6, cyclin D and negative for CD 23 and CD 30. More than 95% of tumor cells expressed Ki-67, while 10% expressed MUM-1 and BCL2. Benign T cells stained positive for CD3 and CD5. FISH was negative for gene rearrangement involving BCL-6/BCL-2 and C-MYC. Staging PET/CT showed hypermetabolic regions involving the stomach wall, large left neck mass and right lung focus. The neck focus had a max SUV 48.5 (8 fold greater than the other sites), that localized to a soft tissue mass measuring 4.9 x 2.7 cm. FNA of the left-sided thyroid mass showed diffuse large B-cell lymphoma with immunostain positive for CD20 and negative for cytokeratin AE1-3, PAX8, and CD 10. The morphology was similar to that of abnormal lymphoid cells in the gastric biopsy. Patient had normal thyroid function tests but positive autoimmune thyroid disease markers (TPO and anti-TG antibody). Treatment with R-CHOP resulted in shrinkage of neck mass. Conclusion: Hypermetabolic regions revealed by PET/CT at distant sites from primary tumor require further evaluation including biopsy as indicated. Clinical correlation and response to chemotherapy can provide supplemental information in the overall assessment of the disease process.

scholarly journals Multifocal Extranodal Involvement of Diffuse Large B-Cell Lymphoma

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Devrim Cabuk ◽  
Y. Taha Gullu ◽  
Ilknur Basyigit ◽  
Ozgur Acikgoz ◽  
Kazım Uygun ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Malignant Tumors ◽  
Fiberoptic Bronchoscopy ◽  
B Cell Lymphoma ◽  
Thoracic Wall ◽  
Mass Lesion ◽  
Pathological Examination ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas. A 68-year-old male with a prior diagnosis of colon non-Hodgkin lymphoma (NHL) was admitted to the hospital with a complaint of cough, sputum, and dyspnea. The chest radiograph showed right hilar enlargement and opacity at the right middle zone suggestive of a mass lesion. Computed tomography of thorax revealed a right-sided mass lesion extending to thoracic wall with the destruction of the third and the fourth ribs and a right hilar mass lesion. Fiberoptic bronchoscopy was performed in order to evaluate endobronchial involvement and showed stenosis with mucosal tumor infiltration in right upper lobe bronchus. The pathological examination of bronchoscopic biopsy specimen reported diffuse large B-cell lymphoma and the patient was accepted as the endobronchial recurrence of sigmoid colon NHL. The patient is still under treatment of R-ICE (rituximab-ifosfamide-carboplatin-etoposide) chemotherapy and partial regression of pulmonary lesions was noted after 3 courses of treatment.

scholarly journals Primary diffuse large B-cell lymphoma of the dura mater and cranial vault

2006 ◽  
Vol 21 (5) ◽  
pp. 1-4 ◽  
Author(s):  
Marcelo Galarza ◽  
Roberto Gazzeri ◽  
Hamed A. Elfeky ◽  
Robert R. Johnson
Keyword(s):  
Radiation Therapy ◽  
B Cell ◽  
Dura Mater ◽  
Cell Lymphoma ◽  
Rare Event ◽  
B Cell Lymphoma ◽  
Cranial Vault ◽  
Pathological Examination ◽  
Large B Cell Lymphoma ◽  
Large B Cell

✓ Primary high-grade lymphoma of the dura mater and cranial vault has rarely been reported. The authors treated a 61-year-old man who presented with a slow-growing scalp mass that involved the cranial vertex. Magnetic resonance imaging revealed an oval mass of the dural type with peripheral edema in the bilateral parietal region, with attachment to the cranial vault and extension to the subgaleal space. After subtotal resection, pathological examination yielded a diagnosis of malignant large B-cell lymphoma. Twenty-three months postoperatively, after undergoing radiation therapy and chemotherapy, the patient is neurologically intact and without systemic dissemination of the malignancy. This is a case of primary malignant B-cell lymphoma of the dura mater with extensive involvement of the skull, which is a very rare event. Imaging-based diagnosis and combined therapy consisting of surgery, radiation therapy, and chemotherapy for the disease are discussed, and the literature on extraaxial malignant lymphomas is extensively reviewed.

scholarly journals Primary diffuse large B-cell lymphoma of endometrium

2015 ◽  
Vol 1 (1) ◽  
pp. 36 ◽  
Author(s):  
Yuqing Zou ◽  
Hongmin Zhao ◽  
Jianhua Gao ◽  
Hong Zhu ◽  
Yong Li ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Radical Surgery ◽  
B Cell Lymphoma ◽  
Abdominal Hysterectomy ◽  
Pathological Examination ◽  
Large B Cell Lymphoma ◽  
Uterine Curettage ◽  
Varied Range ◽  
Large B Cell

<p class="BodyText1">This article was designed to analyze the prognosis and to explore the clinical characteristics and treatment of a case of primary diffuse large B-cell lymphoma (DLBCL) of the endometrium, through a detailed report. <strong>Methods</strong>: This report was done by analyzing a case through its clinical features, pathological examination and immunophenotyping. We believe that this would allow us to forecast the prognosis of the case. <strong>Case Description</strong>: The patient was admitted because of irregular postmenopausal vaginal bleeding for more than a month. She underwent a series of surgical procedures that included abdominal hysterectomy, bilateral adnexectomy, pelvic lymph node dissection and enterolysis owing to the assessed pathological results after uterine curettage. The postoperative pathological results showed that it was a DLBCL. <strong>Conclusion</strong>: Primary DLBCL of the endometrium is rarely reported. Its diagnosis and differential diagnosis mainly depends on pathological examination and immunophenotyping. Radical surgery combined with chemotherapy may be an ideal mode of treatment. The prognosis of the disease has a varied range but radical surgery combined with chemotherapy may improve her quality of life and prolong her survival period.</p>

Diffuse large B cell lymphoma mimics myasthenia gravis

2019 ◽  
Vol 41 (3) ◽  
pp. 727-728
Author(s):  
Veronika Rutar Gorišek ◽  
David Zupančič ◽  
Janez Zidar ◽  
Alenka Horvat Ledinek
Keyword(s):  
Myasthenia Gravis ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell
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