scholarly journals Iris metastasis of diffuse large B-cell lymphoma misdiagnosed as primary angle-closure glaucoma: A case report and review of the literature

2021 ◽  
Vol 16 (1) ◽  
pp. 61-68
Author(s):  
Zebing Li ◽  
Zhongjing Lin ◽  
Yisheng Zhong ◽  
Xi Shen
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Therapeutic Option ◽  
B Cell Lymphoma ◽  
Angle Closure ◽  
Pathological Examination ◽  
Iris Metastasis ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Background Lymphoma with intraocular metastasis is an uncommon and serious disease. We describe a case of diffuse large B-cell lymphoma (DLBCL) with iris metastasis. Meanwhile, we refer to published case reports retrieved via a PubMed search to summarize this rare disease. Case presentation Glaucoma and uveitis symptoms were found in the left eye of a 50-year-old woman upon admission to the hospital. After treatment and pathological examination, the iris of her left eye was diagnosed with DLBCL. Given the patient’s unfavorable treatment options in the local hospital, primary enucleation was offered as a therapeutic option. Conclusions Iris metastasis of systemic lymphoma is an extremely rare ophthalmic disease with poor prognosis. Ophthalmologists should be able to definitively and differentially diagnose eye symptoms and pay attention to systemic conditions to provide a series of optimized treatments.

Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma

2019 ◽  
Vol 69 (3) ◽  
pp. 148-154 ◽  
Author(s):  
Ayako Sakakibara ◽  
Yuichiro Inagaki ◽  
Eiki Imaoka ◽  
Yu Sakai ◽  
Masafumi Ito ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Autopsy Case ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Primary high-grade diffuse large B-cell lymphoma of the glans penis

2021 ◽  
Vol 14 (11) ◽  
pp. e243844
Author(s):  
Marylou Fenech ◽  
David Pisani ◽  
David James Camilleri
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Hand Surgery ◽  
B Cell Lymphoma ◽  
Treatment Modalities ◽  
Successful Outcome ◽  
Large B Cell Lymphoma ◽  
Proper Diagnosis ◽  
Large B Cell

Diffuse large B-cell lymphoma (DLBCL) of the penis is a rare haematological malignancy, with less than 30 cases being reported in the literature. Our case mentions a 57-year-old man who presented with a penile lesion that was diagnosed as DLBCL on histological biopsy. Targeted investigation and proper diagnosis are essential to distinguish it from squamous cell carcinoma (SCC) of the glans, which presents similarly. Since guidelines are not available, the author compared different management mentioned in case reports and the outcome was noted. Chemotherapy, radiotherapy and surgery were the treatment modalities most used; out of which, chemotherapy had the most successful outcome. On the other hand, surgery is the preferred modality in SCC of the penis. This further consolidates the need for guidelines with regard to proper diagnosis and management of this malignancy.

Breast Implant-Associated EBV-Positive Diffuse Large B-cell Lymphoma: Two case reports and literature review

2021 ◽  
pp. 153589
Author(s):  
Sarah Morgan ◽  
Rosemarie Tremblay-LeMay ◽  
Joan E. Lipa ◽  
Monalisa Sur ◽  
Jan Delabie ◽  
...  
Keyword(s):  
Literature Review ◽  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Breast Implant ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

CD4-positive diffuse large B cell lymphoma identified by flow cytometry: two case reports

2010 ◽  
Vol 92 (1) ◽  
pp. 198-203 ◽  
Author(s):  
Marisa Arrondini ◽  
Antonella Barreca ◽  
Sabrina Aliberti ◽  
Anna Demurtas ◽  
Fabrizio Tondat ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Diffuse large B cell lymphoma of the cranial vault: two case reports

2015 ◽  
Vol 32 (4) ◽  
pp. 275-280 ◽  
Author(s):  
Ryosuke Tashiro ◽  
Masayuki Kanamori ◽  
Hiroyoshi Suzuki ◽  
Akihiro Utsunomiya ◽  
Kuniaki Meguro ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Cranial Vault ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Man Nie ◽  
Likun Du ◽  
Weicheng Ren ◽  
Julia Joung ◽  
Xiaofei Ye ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Therapeutic Option ◽  
B Cell Lymphoma ◽  
Synthetic Lethal Interaction ◽  
Synthetic Lethal ◽  
Large B Cell Lymphoma ◽  
Genome Wide ◽  
A Genome ◽  
Large B Cell

AbstractDiffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoid malignancy and a highly heterogeneous disease. In this study, we performed whole-genome and transcriptome sequencing, and a genome-wide CRISPR-Cas9-knockout screen to study an activated B-cell-like DLBCL cell line (RC-K8). We identified a distinct pattern of genetic essentialities in RC-K8, including a dependency on CREBBP and MDM2. The dependency on CREBBP is associated with a balanced translocation involving EP300, which results in a truncated form of the protein that lacks the critical histone acetyltransferase (HAT) domain. The synthetic lethal interaction between CREBBP and EP300 genes, two frequently mutated epigenetic modulators in B-cell lymphoma, was further validated in the previously published CRISPR-Cas9 screens and inhibitor assays. Our study suggests that integration of the unbiased functional screen results with genomic and transcriptomic data can identify both common and unique druggable vulnerabilities in DLBCL and histone acetyltransferases inhibition could be a therapeutic option for CREBBP or EP300 mutated cases.

scholarly journals Multifocal Extranodal Involvement of Diffuse Large B-Cell Lymphoma

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Devrim Cabuk ◽  
Y. Taha Gullu ◽  
Ilknur Basyigit ◽  
Ozgur Acikgoz ◽  
Kazım Uygun ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Malignant Tumors ◽  
Fiberoptic Bronchoscopy ◽  
B Cell Lymphoma ◽  
Thoracic Wall ◽  
Mass Lesion ◽  
Pathological Examination ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas. A 68-year-old male with a prior diagnosis of colon non-Hodgkin lymphoma (NHL) was admitted to the hospital with a complaint of cough, sputum, and dyspnea. The chest radiograph showed right hilar enlargement and opacity at the right middle zone suggestive of a mass lesion. Computed tomography of thorax revealed a right-sided mass lesion extending to thoracic wall with the destruction of the third and the fourth ribs and a right hilar mass lesion. Fiberoptic bronchoscopy was performed in order to evaluate endobronchial involvement and showed stenosis with mucosal tumor infiltration in right upper lobe bronchus. The pathological examination of bronchoscopic biopsy specimen reported diffuse large B-cell lymphoma and the patient was accepted as the endobronchial recurrence of sigmoid colon NHL. The patient is still under treatment of R-ICE (rituximab-ifosfamide-carboplatin-etoposide) chemotherapy and partial regression of pulmonary lesions was noted after 3 courses of treatment.

scholarly journals All That Wheezes Is Not Asthma: A Case of Diffuse Large B-Cell Lymphoma of the Larynx

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Bushra Rahman ◽  
Jawad Bilal ◽  
Qurat Ul Ain Riaz Sipra ◽  
Irbaz Bin Riaz
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Laryngeal Neoplasms ◽  
Diagnostic Challenge ◽  
Large B Cell Lymphoma ◽  
Acute Airway Obstruction ◽  
High Index Of Suspicion ◽  
Large B Cell

Localized laryngeal lymphoma is a rare entity with an incidence of less than 1% of all laryngeal neoplasms. Diffuse large B-cell lymphoma (DLBCL) is the most common type of laryngeal neoplasms. Here, we describe a case of a young 28-year-old female with large B-cell lymphoma who remained undiagnosed for a long time owing to a myriad of nonspecific presentation including “wheezing.” Although primary laryngeal lymphomas constitute a diagnostic challenge since they are rare, one should have a high index of suspicion for lymphoma of the larynx in patients presenting with unresolved wheezing as it can present catastrophically with acute airway obstruction requiring immediate surgical intervention which was observed in this case. Treatment includes radiotherapy, chemotherapy, immunotherapy, or a combination of these. We hope that the discussions ensuing from case reports regarding uncommon presentations of laryngeal lymphoma may spur the formation of regional/international databases for the description of lymphomas with unusual presentations. This effort can lead to in-depth study of cases and prompt awareness of “rare and subtle presentations” of laryngeal lymphoma.

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