scholarly journals Correction to: Evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shouhong Wang ◽  
Yun-Bo Shi
Keyword(s):  
Xenopus Laevis ◽  
Xenopus Tropicalis ◽  
Evolutionary Divergence ◽  
Tail Regeneration

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shouhong Wang ◽  
Yun-Bo Shi
Keyword(s):  
Xenopus Laevis ◽  
Refractory Period ◽  
Genetic Basis ◽  
Diploid Species ◽  
Xenopus Tropicalis ◽  
Evolutionary Divergence ◽  
Tail Regeneration ◽  
Genetic Studies ◽  
Spinal Cord Dorsal ◽  
Organ Replacement

AbstractTissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate. Anuran Xenopus laevis has been used as a model to study regeneration as many tadpole organs can regenerate. In particular, the tail, which consists of many axial and paraxial tissues, such as spinal cord, dorsal aorta and muscle, commonly present in vertebrates, can fully regenerate when amputated at late embryonic stages and most of the tadpole stages. Interestingly, between stage 45 when feeding begins to stage 47, the Xenopus laevis tail cannot regenerate after amputation. This period, termed “refractory period”, has been known for about 20 years. The underlying molecular and genetic basis is unclear in part due to the difficult to carry out genetic studies in this pseudo-tetraploid species. Here we compared tail regeneration between Xenopus laevis and the highly related diploid anuran Xenopus tropicalis and found surprisingly that Xenopus tropicalis lacks the refractory period. Further molecular and genetic studies, more feasible in this diploid species, should reveal the basis for this evolutionary divergence in tail regeneration between two related species and facilitate the understanding how tissue regenerative capacity is controlled, thus with important implications for human regenerative medicine.

scholarly journals Effects of freezing and activation on membrane quality and DNA damage in Xenopus tropicalis and Xenopus laevis spermatozoa

2017 ◽  
Vol 29 (8) ◽  
pp. 1556 ◽  
Author(s):  
S. Morrow ◽  
J. Gosálvez ◽  
C. López-Fernández ◽  
F. Arroyo ◽  
W. V. Holt ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Membrane Damage ◽  
Membrane Integrity ◽  
Subsequent Development ◽  
Xenopus Tropicalis ◽  
Model Organisms ◽  
Sperm Chromatin ◽  
Dna Integrity ◽  
Sperm Cryopreservation ◽  
Sperm Plasma Membrane

There is growing concern over the effect of sperm cryopreservation on DNA integrity and the subsequent development of offspring generated from this cryopreserved material. In the present study, membrane integrity and DNA stability of Xenopus laevis and Xenopus tropicalis spermatozoa were evaluated in response to cryopreservation with or without activation, a process that happens upon exposure to water to spermatozoa of some aquatic species. A dye exclusion assay revealed that sperm plasma membrane integrity in both species decreased after freezing, more so for X. laevis than X. tropicalis spermatozoa. The sperm chromatin dispersion (SCD) test showed that for both X. tropicalis and X. laevis, activated frozen spermatozoa produced the highest levels of DNA fragmentation compared with all fresh samples and frozen non-activated samples (P < 0.05). Understanding the nature of DNA and membrane damage that occurs in cryopreserved spermatozoa from Xenopus species represents the first step in exploiting these powerful model organisms to understand the developmental consequences of fertilising with cryopreservation-damaged spermatozoa.

Patterns of Mitosis and Activation of the Map-Kinase Cascade during Tadpole Tail Regeneration in the Refractory Period of Xenopus laevis Development

2018 ◽  
Vol 49 (5) ◽  
pp. 260-263
Author(s):  
A. S. Ivanova ◽  
G. V. Ermakova ◽  
A. G. Zaraisky ◽  
M. B. Tereshina
Keyword(s):  
Xenopus Laevis ◽  
Map Kinase ◽  
Refractory Period ◽  
Tail Regeneration ◽  
Map Kinase Cascade ◽  
Tadpole Tail ◽  
Kinase Cascade

scholarly journals Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos

2018 ◽  
pp. 19-32 ◽  
Author(s):  
Marcin Wlizla ◽  
Sean McNamara ◽  
Marko E. Horb
Keyword(s):  
Xenopus Laevis ◽  
Xenopus Tropicalis

A Level Set Approach to Simulating Xenopus laevis Tail Regeneration

2016 ◽  
Author(s):  
Zachary Serlin ◽  
Jason Rife ◽  
Michael Levin
Keyword(s):  
Xenopus Laevis ◽  
Level Set ◽  
Tail Regeneration ◽  
Level Set Approach

scholarly journals In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration

2016 ◽  
Vol 21 (4) ◽  
pp. 358-369 ◽  
Author(s):  
Miyuki Suzuki ◽  
Chiyo Takagi ◽  
Shinichirou Miura ◽  
Yuto Sakane ◽  
Makoto Suzuki ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Histone H3 ◽  
Tail Regeneration

Thyroid-stimulating hormone (TSH): Measurement of intracellular, secreted, and circulating hormone in Xenopus laevis and Xenopus tropicalis

2011 ◽  
Vol 171 (3) ◽  
pp. 319-325 ◽  
Author(s):  
Joseph J. Korte ◽  
Robin M. Sternberg ◽  
Jose A. Serrano ◽  
Kara R. Thoemke ◽  
Scott M. Moen ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Thyroid Stimulating Hormone ◽  
Xenopus Tropicalis ◽  
Stimulating Hormone

scholarly journals Hif1α is required for Wnt regulated gene expression during Xenopus tropicalis tail regeneration

2021 ◽  
Author(s):  
Jeet H Patel ◽  
Preston A Schattinger ◽  
Evan E Takayoshi ◽  
Andrea Elizabeth Wills
Keyword(s):  
Gene Expression ◽  
Hox Genes ◽  
Xenopus Tropicalis ◽  
Neural Patterning ◽  
Tail Regeneration ◽  
Induced Stress ◽  
Developmental Signaling ◽  
Early Injury ◽  
Responsive Element ◽  
Regulated Gene Expression

Regeneration of complex tissues is initiated by an injury-induced stress response, eventually leading to activation of developmental signaling pathways, such as Wnt signaling. How early injury cues are interpreted and coupled to activation of these developmental signals and their targets is not well understood. Here, we show that Hif1α, a stress induced transcription factor, is required for tail regeneration in Xenopus tropicalis. We find that Hif1α is required for regeneration of differentiated axial tissues, including axons and muscle. Using RNA-sequencing, we find that Hif1α and Wnt converge on a broad set of genes required for posterior specification and differentiation, including the posterior hox genes. We further show that Hif1α is required for transcription via a Wnt-responsive element, a function that is conserved in both regeneration and early neural patterning. Our findings indicate a regulatory role for Hif1α in Wnt mediated gene expression across multiple tissue contexts.

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