Maxillary sinus lift response to platelet-rich plasma associated with autogenous bone, ceramic biphasic HA/β-TCP (70:30), or deproteinized bovine bone

Abstract Background This study evaluated the long-term effects of platelet-rich plasma (PRP) on bone formation and regeneration when associated with autogenous bone graft (AB), porous biphasic calcium phosphate (pBCP), or deproteinized bovine bone (DBB) in maxillary sinus augmentation (MSA) of rabbit. Methods In 54 rabbits, bilateral MSA procedure was performed and randomly one sinus was filled with 200 mm3 material plus blood clot (AB/clot, DBB/clot, and pBCP/clot) and other with the same graft plus PRP (AB/PRP, DBB/PRP, and pBCP/PRP). After 30, 60, and 180 days, microtomographic were performed to analyze the three-dimensional MSA volume and histomorphometric analyses for the percentage of bone and soft tissues ingrowth. Data were compared by two-way ANOVA and the means were compared by the Tukey test, at p < 0.05. Results The percentage of pBCP and DBB were nearly unchanged throughout the whole period and bone formation occurred in the spaces between particles. The MSA volume filled with DBB and pBCP agglutinated with clot and PRP maintained constant during all experimental periods (147.2 mm3 and 154.9 mm3, respectively, p = 0.7377), and no significant changes in the new formatted bone and soft tissue were observed between treatments. In AB/clot and AB/PRP, the MSA volume was similar at 30 days (140.3 mm3 and 137.9 mm3, respectively), but a higher and gradual reduction was observed until 180 days. In the AB/PRP, this reduction was significantly higher (44.2%) than AB/clot (22.5%) (p = 0.01792). Histologically, the addition of PRP to AB accelerated the new bone formation/remodeling maintaining the percentage of new bone similar to AB/clot during all experimental volume (p = 0.6406), while the AB particles showed a higher resorption in AB/PRP than AB/clot until 60 days (mean of 7.8% and 15.1%, respectively, p = 0.0396). Conclusion The association of PRP with the autogenous graft accelerates the process of bone formation/remodeling in MSA, but not had influence on the pBCP and DBB groups.

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Maxillary Sinus Augmentation with Deproteinized Bovine Bone (Bio-Oss®) and Impladent® Dental Implant System Part II. Evaluation of Deprotienized Bovine Bone (Bio-Oss®) and Implant Surface

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2019.75 ◽

2002 ◽

Vol 45 (4) ◽

pp. 167-171 ◽

Cited By ~ 8

Author(s):

Samer Kasabah ◽

Antonín Šimůnek ◽

Jiří Krug ◽

Miguel Cevallos Lecaro

Keyword(s):

Maxillary Sinus ◽

Titanium Implants ◽

Autogenous Bone ◽

Bovine Bone ◽

Implant Surface ◽

Sinus Augmentation ◽

Suitable Material ◽

Group 2 ◽

Group 1 ◽

Deproteinized Bovine Bone

The objective of this clinical study was to determine the predictability of endosseous implant placed in a maxillary sinus augmented with deproteinized bovine bone (Bio-Oss®). A total of 185 implants (109 titanium and 76 hydroxyapatite- coated) were placed in 77 patients representing 92 sinuses either a one- or two-stage surgical technique. A mixture of venous patient’s blood and Bio-Oss® was used alone within 20 sinuses (Group 1), or in combination with autogenous bone within 72 sinuses (Group 2). Thirty-nine implants were placed in Group 1 and 147 implants were inserted in Group 2. The grafted sinuses were evaluated clinically and radiographically at second stage surgery. According to certain criteria, of the implants placed, only two titanium implants (1.08 %) failed with 98.91 % implant survival. There was no statistically variable difference for the use of hydroxyapatite-coated or titanium implants. The two failed implants were from Group 2. No clinical benefit has been achieved from the combination with autogenous bone (P<0.05). All the grafted sinuses were sufficient to place dental implants of at least 12 mm length (100 % graft success). The results of this short-term study support the hypothesis that Bio-Oss® can be a suitable material for sinus augmentation.

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Bioglass Associated With Leukocyte-Poor Platelet-Rich Plasma in the Rabbit Maxillary Sinus: Histomorphometric, Densitometric, and Fractal Analysis

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-09-00072 ◽

2010 ◽

Vol 36 (5) ◽

pp. 333-343 ◽

Cited By ~ 10

Author(s):

Ivy Kiemle Trindade-Suedam ◽

Juliana Aparecida Najarro Dearo de Morais ◽

Rafael Silveira Faeda ◽

Fábio Renato Manzolli Leite ◽

Guilherme Monteiro Tosoni ◽

...

Keyword(s):

Fractal Dimension ◽

Bone Density ◽

Bone Formation ◽

Maxillary Sinus ◽

Platelet Rich Plasma ◽

Autogenous Bone ◽

New Bone Formation ◽

Mean Values ◽

Dimension Analysis ◽

Fractal Dimension Analysis

Abstract The objective of the present study was to evaluate the outcomes of autogenous bone graft (AB) and bioglass (BG) associated or not with leukocyte-poor platelet-rich plasma (LP-PRP) in the rabbit maxillary sinus (MS) by histomorphometric and radiographic analysis. Twenty rabbits divided into 2 groups (G1, G2) were submitted to sinus lift surgery. In G1, 10 MS were grafted with AB and 10 MS were grafted with BG. In G2, 10 MS were grafted with AB + LP-PRP and 10 MS were grafted with BG + LP-PRP. After 90 days, the animals were killed and specimens were obtained, x-rayed, and submitted to histomorphometric, radiographic bone density (RD) and fractal dimension analysis. Radiographic bone density mean values (SD), expressed as aluminum equivalent in mm, of AB, BG, AB + LP-PRP, and BG + LP-PRP groups were 1.79 (0.31), 2.04 (0.39), 1.61 (0.28), and 1.53 (0.30), respectively. Significant differences (P < 0.05) were observed between BG and AB, and BG + PRP and BG. Fractal dimension mean values were 1.48 (0.04), 1.35 (0.08), 1.44 (0.04), and 1.44 (0.06), respectively. Significant differences were observed between BG and AB, and AB + LP-PRP and BG. Mean values for the percentage of bone inside MS were 63.30 (8.60), 52.65 (10.41), 55.25 (7.01), and 51.07 (10.25), respectively. No differences were found. No correlations were observed among percentage of bone, RD and FD. Histological analysis showed that MS treated with AB presented mature and new bone formation. The other groups showed minor bone formation. Within the limitations of this study, the results indicated that at a 90-day time end point, AB yielded better results than AB + LP-PRP, BG, and BG + LP-PRP and should be considered the primary material for MS augmentation.

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