Correlating cognition and cortical excitability with pain in fibromyalgia: a case control study

Abstract Background Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal symptoms, primarily attributed to sensitization of somatosensory system carrying pain. Few reports have investigated the impact of fibromyalgia symptoms on cognition, corticomotor excitability, sleepiness, and the sleep quality — all of which can deteriorate the quality of life in fibromyalgia. However, the existing reports are underpowered and have conflicting directions of findings, limiting their generalizability. Therefore, the present study was designed to compare measures of cognition, corticomotor excitability, sleepiness, and sleep quality using standardized instruments in the recruited patients of fibromyalgia with pain-free controls. Methods Diagnosed cases of fibromyalgia were recruited from the Rheumatology department for the cross-sectional, case-control study. Cognition (Mini-Mental State Examination, Stroop color-word task), corticomotor excitability (Resting motor threshold, Motor evoked potential amplitude), daytime sleepiness (Epworth sleepiness scale), and sleep quality (Pittsburgh sleep quality index) were studied according to the standard procedure. Results Thirty-four patients of fibromyalgia and 30 pain-free controls were recruited for the study. Patients of fibromyalgia showed decreased cognitive scores (p = 0.05), lowered accuracy in Stroop color-word task (for color: 0.02, for word: 0.01), and prolonged reaction time (< 0.01, < 0.01). Excessive daytime sleepiness in patients were found (< 0.01) and worsened sleep quality (< 0.01) were found. Parameters of corticomotor excitability were comparable between patients of fibromyalgia and pain-free controls. Conclusions Patients of fibromyalgia made more errors, had significantly increased reaction time for cognitive tasks, marked daytime sleepiness, and impaired quality of sleep. Future treatment strategies may include cognitive deficits and sleep disturbances as an integral part of fibromyalgia management.

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Subjective sleep disorders and daytime sleepiness in patients with restrictive type anorexia nervosa and effects on quality of life: a case-control study.

10.21203/rs.3.rs-167173/v1 ◽

2021 ◽

Author(s):

Andrea Romigi ◽

Nicola B. Mercuri ◽

Marco Caccamo ◽

Federica Testa ◽

Giuseppe Vitrani ◽

...

Keyword(s):

Quality Of Life ◽

Anorexia Nervosa ◽

Sleep Quality ◽

Sleep Disorders ◽

Daytime Sleepiness ◽

Case Control Study ◽

Case Control ◽

Physical Role ◽

Control Study

Abstract Purpose To evaluate sleep disorders and daytime drowsiness in a cohort of patients affected by anorexia nervosa (AN) and their impact on health-related quality of life (HRQoL). Method We evaluated AN patients and healthy controls (C) by the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Beck Depression Index. We also utilized the Short-Form Health Survey (SF-36) questionnaire to assess HRQoL in both AN and C. Results: Twenty-eight out of 34 AN patients (82.3%) had a pathological PSQI score while 10/34 (29.4%) healthy subjects (p<0.0001). The overall PSQI score was significantly higher in AN than in the controls (p=0.0004). The components sleep quality (p=0.008), sleep duration (p=0.03), sleep efficiency (p=0.004), sleep disturbances (p=0.01) and daytime dysfunction (p=0.002) were higher than C. SF36 showed significantly reduced scores of standardized physical components (p=0.01) and standardized mental components (p<0.0001) in AN, while physical function (p=0.0001), physical role (p=0.0005) and general health (p<0.0001), vitality (p=0.001), social functioning (p=0.0006) emotional role (p=0.002) and mental health (p<0.0001) were significantly decreased in AN. We found a significant correlation between the PSQI score and the physical role (r=-0.35, p=0.03) and education (r=0.38, p=0.02).Conclusion We demonstrated low sleep quality lacking subjective daytime sleepiness in AN. Sleep quality correlated significantly with HRQoL (physical role) and level of education. Level of evidence: level III case-control study

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Evaluation of Anxiety Levels and Sleep Quality of Family Members Providing Home Care Services: A Case-Control Study

Turkish Journal of Family Medicine & Primary Care ◽

10.21763/tjfmpc.765490 ◽

2020 ◽

Author(s):

Nurcan AKBAŞ GÜNEŞ

Keyword(s):

Sleep Quality ◽

Home Care ◽

Case Control Study ◽

Family Members ◽

Home Care Services ◽

Case Control ◽

Care Services ◽

Anxiety Levels ◽

Control Study

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A Case-Control Study on Excessive Daytime Sleepiness in Episodic Migraine

Cephalalgia ◽

10.1111/j.1468-2982.2007.01399.x ◽

2007 ◽

Vol 27 (10) ◽

pp. 1115-1119 ◽

Cited By ~ 47

Author(s):

P Barbanti ◽

G Fabbrini ◽

C Aurilia ◽

N Vanacore ◽

G Cruccu

Keyword(s):

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Case Control Study ◽

Sleep Problems ◽

Episodic Migraine ◽

Case Control ◽

Anxiety And Depression ◽

Affective Symptoms ◽

Control Study

Migraine patients often complain of sleepiness, a problem that manifests both during and outside an attack, may impair the quality of life and can lead to potentially harmful situations. Findings from an uncontrolled study suggest that a high percentage of migraineurs experience excessive daytime sleepiness (EDS). We investigated EDS in a case-control study on 100 patients with episodic migraine and 100 age- and sex-matched healthy controls and also assessed sleep quality, anxiety and depression. Although it was found that EDS was more frequent in migraineurs than in controls (14% vs. 5%; odds ratio 3.1; 95% confidence interval 1.1–8.9), the frequency was lower than previously reported. EDS correlated with migraine disability, sleep problems and anxiety. EDS in patients with migraine probably stems from the full constellation of headache-sleep-affective symptoms resulting from the complex clinical burden of the disease.

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