Trial of a Sustained Release Form of Amitriptyline (Lentizol) in the Treatment of Depressive Illness

1973 ◽  
Vol 123 (572) ◽  
pp. 69-71 ◽  
Author(s):  
G. Sedman
Keyword(s):  
Single Dose ◽  
Sustained Release ◽  
Dosage Level ◽  
Depressive Illness ◽  
Double Blind ◽  
Sustained Release Form ◽  
Release Form

The advantages of a new sustained release form of amitriptyline (Lentizol) which can be given in a single dose for the treatment of depressive illness have recently been described by Sims (1972) and Haider (1972). This paper reports a similar double blind cross-over trial in the treatment of depressive illness (ICD 296) of the same substance compared against conventional amitriptyline at an overall higher dosage level.

A Single Daily Dose of a New Form of Amitriptyline in Depressive Illness

1972 ◽  
Vol 120 (558) ◽  
pp. 521-522 ◽  
Author(s):  
Ijaz Haider
Keyword(s):  
Sustained Release ◽  
Clinical Experience ◽  
Depressive Illness ◽  
Single Daily Dose ◽  
Once Daily ◽  
Sustained Release Form ◽  
Daily Dose ◽  
The Common ◽  
New Form ◽  
Release Form

In order to try to overcome the common clinical experience of patients who do not take the drugs prescribed for them (Wilcox et al., 1965) a sustained release form of amitriptyline (Lentizol) has recently been made available. This trial was undertaken to test the efficacy of this formulation given once daily at night compared to standard amitriptyline given thrice daily.

Clinical Trial Comparison of a Sustained Release Form of Amitriptyline with Dothiepin

1980 ◽  
Vol 8 (4) ◽  
pp. 286-292 ◽  
Author(s):  
T Dorman
Keyword(s):  
Clinical Trial ◽  
Sustained Release ◽  
Admission Criteria ◽  
Double Blind ◽  
Release Preparation ◽  
Sustained Release Form ◽  
Trial Subject ◽  
The Mean ◽  
Release Form ◽  
Group Trial

A double-blind between-group trial was undertaken in fifty depressed patients to compare the efficacy of a sustained release form of amitriptyline (Lentizol®) with dothiepin (Prothiaden®) over a 5-week period. Patients fulfilling defined admission criteria were randomly allocated to treatment with evening dosage of either 50 mg of the sustained release preparation or 75 mg of dothiepin for the first week of the trial. Subject to review as necessary, these dosages were doubled at the end of the first week. Both drugs effected significant and appreciable improvement over the 5-week period, with the mean responses at the end of the trial retaining the same relative positions as at the beginning.

Human Availability Studies of Five Vitamins in Sustained Release Form

1961 ◽  
Vol 9 (3) ◽  
pp. 324-330 ◽  
Author(s):  
SAMUEL M. GREENBERG ◽  
JOHN F. HERNDON ◽  
DONALD R. MACDONNELL ◽  
THOMAS L. FLANAGAN ◽  
AMADEO BONDI
Keyword(s):  
Sustained Release ◽  
Sustained Release Form ◽  
Release Form

scholarly journals Depressive symptoms as a side effect of the sustained release form of methylphenidate in a 7-year-old boy with attention-deficit hyperactivity disorder

2012 ◽  
Vol 69 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Aneta Lakic
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Depressive Symptoms ◽  
Side Effects ◽  
Sustained Release ◽  
Attention Deficit ◽  
Depressive Symptomatology ◽  
Hyperactivity Disorder ◽  
Sustained Release Form ◽  
The Brain ◽  
Release Form

Introduction. Hyperkinetic disorder or attention-deficit hyperactivity disorder (ADHD) is a clinical entity consisting of a cluster of symptoms including hyperactivity, attention disorder and impulse control disorder group. In the context of ADHD etiology we may say that genetic, clinical and imaging studies point out a disruption of the brain dopamine system, which is corroborated by the clinical effectiveness of stimulant drugs, which increase extracellular dopamine in the brain. Basically, it is a biological and not psychological disorder, which is important both for the comprehension and therapeutical approach to this problem. Today, the best recommended approach regarding children with ADHD is a combination of two therapeutic modalities: pharmacotherapy and behavioral treatment. The first-choice drugs for this disorder belong to the group of sympathomimetics - psychostimulants and atomoxetine (more recently). As the firstchoice therapy, methylphenydate in sustained release form has numerous advantages. Like all drugs, methylphenidate has its unwanted side effects. Most common are: loss of appetite, weight loss, sleeping disorders, irritability, headache. These side effects are well-known and documented in the literature. By analysing the available literature we have found cases of psychiatric side effects such as: psychosis, mania, visual hallucinations, agitation, suicidal ideas. We have not found examples of ADHD in children who use increased dosage of sustained release of methylphenidate leading to depressive symptomatology. On the other side, methylphenidate may be prescribed for off-label use in treatmentresistant cases of depression. Case report. The case of a 7- year-old boy diagnosed with ADHD was on a minimal dose of sustained release form of methylphenidate. After initial titration of the drug, i.e. after raising the dose to the next level the boy developed clinical signs of depression. The treatment was ceased and depressive symptoms were withdrawed. Conclusion. Manifestation of depressive symptomatology after dose increasement of sustained release form of methylphenidate in a 7-year-old boy with ADHD represents an uncommon side effect. Precise drug activity mechanisms responsible for the appearance of these symptoms remains to be explained.

Antiischemic effects of a newly developed capsule containing 120 mg isosorbide dinitrate in sustained release form

1988 ◽  
Vol 61 (15) ◽  
pp. 1352-1353 ◽  
Author(s):  
Sigmund Silber ◽  
Astrid C. Vogler ◽  
Franz Spiegelsberger ◽  
Margot Vogel ◽  
Karl Theisen
Keyword(s):  
Sustained Release ◽  
Isosorbide Dinitrate ◽  
Sustained Release Form ◽  
Release Form

Analysis of the Efficiency of Microencapsulated Sustained-Release Form of Naloxone on the Experimental Model of Fentanyl Poisoning

2017 ◽  
Vol 163 (6) ◽  
pp. 737-741 ◽  
Author(s):  
N. G. Vengerovich ◽  
M. A. Yudin ◽  
V. N. Bykov ◽  
A. S. Nikiforov ◽  
O. I. Aleshina ◽  
...  
Keyword(s):  
Sustained Release ◽  
Experimental Model ◽  
Sustained Release Form ◽  
Release Form

‘Dry emulsion’ — a sustained release form: Modelling of drug transfers in liquids

1987 ◽  
Vol 36 (1) ◽  
pp. 81-88 ◽  
Author(s):  
N. Farah ◽  
J. Bouzon ◽  
M. Rollet ◽  
J.L. Taverdet ◽  
J.M. Vergnaud
Keyword(s):  
Sustained Release ◽  
Sustained Release Form ◽  
Dry Emulsion ◽  
Release Form
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