scholarly journals LPLgene variants affect apoC-III response to combination therapy of statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia

2012 ◽  
Vol 53 (3) ◽  
pp. 556-560 ◽  
Author(s):  
Ariel Brautbar ◽  
Salim S. Virani ◽  
John Belmont ◽  
Vijay Nambi ◽  
Peter H. Jones ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Combination Therapy ◽  
Randomized Clinical Trial ◽  
Fenofibric Acid ◽  
Mixed Dyslipidemia

scholarly journals Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia

2011 ◽  
Vol 219 (2) ◽  
pp. 737-742 ◽  
Author(s):  
Ariel Brautbar ◽  
Daniel Covarrubias ◽  
John Belmont ◽  
Fremiet Lara-Garduno ◽  
Salim S. Virani ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Combination Therapy ◽  
Randomized Clinical Trial ◽  
Gene Region ◽  
Fenofibric Acid ◽  
Mixed Dyslipidemia ◽  
Apoa5 Gene

scholarly journals Rosuvastatin and Fenofibrate Combination in The Treatment of Mixed Hyperlipidemia: A Narrative Review

2021 ◽  
Vol 4 (03) ◽  
pp. 867-877
Author(s):  
Kaushik Biswas ◽  
Ajoy Tiwari ◽  
Prachi Jadhav ◽  
Amit Goel ◽  
G V Chanukya
Keyword(s):  
Cardiovascular Risk ◽  
Combination Therapy ◽  
Fenofibric Acid ◽  
Cardiovascular Risk Reduction ◽  
Residual Cardiovascular Risk ◽  
Statin Monotherapy ◽  
Mixed Dyslipidemia ◽  
Lipid Control ◽  
Patient At Risk ◽  
Mixed Hyperlipidemia

Introduction: Patients with mixed dyslipidemia are presented with high levels of low-density lipid cholesterol (LDL-C), triglycerides (TG), and reduced high-density lipid cholesterol (HDL-C). Though useful in lowering LDL-C, therapy with rosuvastatin is insufficient in optimizing the overall lipid profile, thus putting the patient at risk of residual cardiovascular risk. A combination of statin with other lipid-modifying agents has been used with more efficient lipid control and cardiovascular risk prevention. Of these, fenofibric acid is the most frequently used, along with rosuvastatin. Methods: Authors conducted a literature search of published literature to assess the use of rosuvastatin and fenofibrate combination in the management of mixed hyperlipidaemia. Results and discussion: The authors selected a total of 46 articles to be included in the review. Due to the small number of articles and heterogeneity on the combination of rosuvastatin and fenofibrate combination in mixed hyperlipidemia, the findings herein are presented using narrative summaries. Based on the thorough assessment of the selected literature, the essential themes that emerged from the review include safety and efficacy of rosuvastatin and fenofibrate combination, place of therapy of rosuvastatin, and fenofibrate combination, and potential cardiovascular risk reduction with rosuvastatin and fenofibrate combination.   Conclusion: Based on the review, the authors suggested that the combination therapy with fenofibric acid was beneficial, well-tolerated with a similar safety profile compared with statin monotherapy. The combination therapy of moderate dose rosuvastatin and fenofibric acid led to a reduction of cardiovascular risk factors via several pathways.

scholarly journals The Effect of Combination Therapy; Manual Therapy and Exercise, in Patients With Non-Specific Chronic Neck Pain: A Randomized Clinical Trial

2017 ◽  
pp. 113-121 ◽  
Author(s):  
Maryam Ghodrati ◽  
Zahra Mosallanezhad ◽  
Mohsen Shati ◽  
Forouzan Rastgar Koutenaei ◽  
Mohammad Reza Nourbakhsh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Combination Therapy ◽  
Neck Pain ◽  
Randomized Clinical Trial ◽  
Manual Therapy ◽  
Chronic Neck Pain ◽  
Therapy Manual

Efficacy and Safety of Fenofibric Acid and Rosuvastatin Combination Therapy in Women 55 Years or Older (Post-Menopausal) with Mixed Dyslipidemia

2009 ◽  
Vol 3 (3) ◽  
pp. 221-222 ◽  
Author(s):  
Anne Carol Goldberg ◽  
Nanette K. Wenger ◽  
Dawn M. Carlson ◽  
Maureen T. Kelly ◽  
Carolyn M. Setze ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Efficacy And Safety ◽  
Fenofibric Acid ◽  
Mixed Dyslipidemia ◽  
Post Menopausal

Combination therapy with rosuvastatin and fenofibric acid for mixed dyslipidemia: overview of efficacy and safety

2010 ◽  
Vol 5 (5) ◽  
pp. 627-649 ◽  
Author(s):  
Terry A Jacobson ◽  
Peter H Jones ◽  
Eli M Roth
Keyword(s):  
Combination Therapy ◽  
Efficacy And Safety ◽  
Fenofibric Acid ◽  
Mixed Dyslipidemia
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