DNA methylation profile predicts risk of recurrence in tamoxifen-treated, node-negative breast cancer patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 525-525 ◽  
Author(s):  
S. Maier ◽  
I. Nimmrich ◽  
A. Marx ◽  
S. Eppenberger-Castori ◽  
F. Jaenicke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Methylation Profile ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Risk Of Recurrence ◽  
Node Negative Breast Cancer ◽  
Dna Methylation Profile

DNA methylation profile predicts risk of recurrence in tamoxifen-treated, node-negative breast cancer patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 525-525
Author(s):  
S. Maier ◽  
I. Nimmrich ◽  
A. Marx ◽  
S. Eppenberger-Castori ◽  
F. Jaenicke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Methylation Profile ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Risk Of Recurrence ◽  
Node Negative Breast Cancer ◽  
Dna Methylation Profile

Multicenter Study Using Paraffin-Embedded Tumor Tissue Testing PITX2 DNA Methylation As a Marker for Outcome Prediction in Tamoxifen-Treated, Node-Negative Breast Cancer Patients

2008 ◽  
Vol 26 (31) ◽  
pp. 5036-5042 ◽  
Author(s):  
Nadia Harbeck ◽  
Inko Nimmrich ◽  
Arndt Hartmann ◽  
Jeffrey S. Ross ◽  
Tanja Cufer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Hormone Receptor Positive ◽  
Node Negative Breast Cancer ◽  
Fresh Frozen ◽  
Pcr Technology ◽  
Treated Breast

Purpose We recently reported DNA methylation of the paired-like homeodomain transcription factor 2 (PITX2) gene to be strongly correlated with increased risk of recurrence in node-negative, hormone receptor–positive, tamoxifen-treated breast cancer patients using fresh frozen specimens. Aims of the present study were to establish determination of PITX2 methylation for routine analysis in formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and to test PITX2 DNA methylation as a biomarker for outcome prediction in an independent patient cohort. Patients and Methods Real-time polymerase chain reaction (PCR) technology was validated for FFPE tissue by comparing methylation measurements in FFPE specimens with those in fresh frozen specimens from the same tumor. The impact of PITX2 methylation on time to distant metastasis was then evaluated in FFPE specimens from hormone receptor–positive, node-negative breast cancer patients (n = 399, adjuvant tamoxifen monotherapy). Results Reproducibility of the PCR assay in replicate measurements (rs ≥ 0.95; n = 150) and concordant measurements between fresh frozen and FFPE tissues (rs = 0.81; n = 89) were demonstrated. In a multivariate model, PITX2 methylation added significant information (hazard ratio = 2.35; 95% CI, 1.20 to 4.60) to established prognostic factors (tumor size, grade, and age). Conclusion PITX2 methylation can be reliably assessed by real-time PCR technology in FFPE tissue. Together with our earlier studies, we have accumulated substantial evidence that PITX2 methylation analysis holds promise as a practical assay for routine clinical use to predict outcome in node-negative, tamoxifen-treated breast cancer, which might allow, based on future validation studies, the identification of low-risk patients who may be treated by tamoxifen alone.

K167: is it a prognostic index in node negative breast cancer patients?

2001 ◽  
Vol 37 ◽  
pp. S121
Author(s):  
F. Valcamonico ◽  
G. Grigolato ◽  
F. Donato ◽  
V.D. Ferrari ◽  
E. Simoncini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Prognostic Index ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer

OncotypeDX Recurrence Score Does Not Predict Nodal Burden in Clinically Node Negative Breast Cancer Patients

2018 ◽  
Vol 26 (3) ◽  
pp. 815-820 ◽  
Author(s):  
S. E. Tevis ◽  
R. Bassett ◽  
I. Bedrosian ◽  
C. H. Barcenas ◽  
D. M. Black ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Recurrence Score ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Nodal Burden

scholarly journals Arm lymphoedema and upper limb impairments in sentinel node-negative breast cancer patients: A one year follow-up study

The Breast ◽  
2016 ◽  
Vol 29 ◽  
pp. 102-108 ◽  
Author(s):  
An De Groef ◽  
Marijke Van Kampen ◽  
Elena Tieto ◽  
Petra Schönweger ◽  
Marie-Rose Christiaens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Upper Limb ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Follow Up Study ◽  
Node Negative Breast Cancer ◽  
Arm Lymphoedema ◽  
One Year
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