Concurrent or sequential adjuvant hormonoradiotherapy after conservative surgery for early stage breast cancer: First results of the CO-HO-RT phase II randomized trial

Purpose The optimal integration of chemotherapy with radiation (RT) for patients with early-stage breast cancer remains uncertain. We present the long-term results of a prospective randomized trial to address this question. Patients and Methods Two hundred forty-four patients were randomly assigned after conservative breast surgery to receive 12 weeks of cyclophosphamide, doxorubicin, methotrexate, fluorouracil, and prednisone (CAMFP) before RT (CT-first) or after RT (RT-first). Median follow-up for surviving patients was 135 months. Results There were no significant differences between the CT-first and RT-first arms in time to any event, distant metastasis, or death. Sites of first failure were also not significantly different. Conclusion Among breast cancer patients treated with conservative surgery, there is no advantage to giving RT before adjuvant chemotherapy. However, this study does not have enough statistical power to rule out a clinically important survival benefit for either sequence.

Download Full-text

163 Contralateral breast cancer after conservative surgery and radiation therapy in early-stage breast cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(99)90181-5 ◽

1999 ◽

Vol 45 (3) ◽

pp. 231-232

Author(s):

J.S. Wong ◽

J.E. Garber ◽

A.J. Nixon ◽

R. Gelman ◽

A. Recht ◽

...

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Contralateral Breast Cancer ◽

Early Stage ◽

Conservative Surgery ◽

Contralateral Breast ◽

Early Stage Breast Cancer

Download Full-text

Subcutaneous Quadrantectomy Is A Safe Procedure in Management of Early Stage Breast Cancer.

10.21203/rs.3.rs-892576/v1 ◽

2021 ◽

Author(s):

Eva Lieto ◽

Annamaria Auricchio ◽

Silvia Erario ◽

Giovanni Del Sorbo ◽

Francesca Cardella

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Axillary Dissection ◽

Early Stage ◽

Length Of Hospital Stay ◽

Oncologic Outcome ◽

Conservative Surgery ◽

Early Stage Breast Cancer ◽

Safe Procedure

Abstract Background: Surgical treatment of breast cancer, the most frequent cancer in women, is deeply changed in the last years turning towards a progressive minimally invasion, both in extend of demolition and in axillary dissection completeness. This is due to the flexibility of the concept of radicality that today is taylored on the patient, rather than on the disease; If oncologic radicality is preserved, a less invasive operation on the breast is mandatory. In the era of mini-invasive surgery, a patient may ask for an aesthetic care without any additional health risk.Methods: In this article, we compared two groups of 75 consecutive patients undergoing conservative surgery for early stage breast cancer; the two groups were randomized for standard quadrantectomy and totally subcutaneous quadrantectomy. Statistical analysis was carried out for comparing data.Results: No difference in oncologic outcome was found with the different surgical procedures; the length of hospital stay and the incidence of late breast deformities were significantly less in subcutaneous quadrantectomy group. Conclusions: We conclude that, in early breast cancer, a totally subcutaneous surgical procedure of resection is feasible and safe and ensures an absolutely better aesthetical result, that involves patient’s quality of life.

Download Full-text