Diagnostic Medical Radiation Exposure in Surveillance of Aggressive Lymphoma: Clinical Trial Design Should Reflect Clinical Practice

2015 ◽  
Vol 33 (10) ◽  
pp. 1219-1220 ◽  
Author(s):  
Eliza A. Hawkes ◽  
Geoff Chong ◽  
Andrew Grigg
Keyword(s):  
Clinical Trial ◽  
Clinical Practice ◽  
Radiation Exposure ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Aggressive Lymphoma ◽  
Medical Radiation ◽  
Medical Radiation Exposure

M1319 Do IBS Patients Understand the Difference Between Abdominal Pain vs. Discomfort? Implications for Clinical Practice and Clinical Trial Design

2010 ◽  
Vol 138 (5) ◽  
pp. S-379
Author(s):  
Brennan M. Spiegel ◽  
Roger E. Bolus ◽  
Lucinda A. Harris ◽  
Susan L. Lucak ◽  
Eric Esrailian ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Abdominal Pain ◽  
Clinical Practice ◽  
Trial Design ◽  
Clinical Trial Design ◽  
The Difference

scholarly journals Current state and comparison of the clinical development of bevacizumab, rituximab and trastuzumab biosimilars

2021 ◽  
Author(s):  
Luis Pérez Díaz ◽  
Susana Millán ◽  
Nuran Chaban ◽  
Ana del Campo ◽  
Eduardo Spitzer
Keyword(s):  
Clinical Trial ◽  
Monoclonal Antibodies ◽  
Clinical Practice ◽  
Clinical Management ◽  
Trial Design ◽  
Clinical Trial Design ◽  
Clinical Development ◽  
Point Selection ◽  
Substantial Impact ◽  
Current State

Monoclonal antibodies are highly complex, large and biologic products with a substantial impact on the clinical management of a variety of diseases including cancer. The expiry of patents for essential monoclonal antibodies in cancer care such as bevacizumab, rituximab and trastuzumab, has prompted the global development of biosimilars to balance the biologics market. However, an understanding of the different approach of biosimilar development compared with its reference medicinal product, especially in the context of clinical trial design and end point selection may help oncologists integrating biosimilars into clinical practice. Herein, we reviewed the clinical development of biosimilars in oncology comparing the available clinical data of proposed biosimilars of bevacizumab, rituximab and trastuzumab.

Integrating radiomics into clinical trial design

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
Jessica J. Waninger ◽  
Michael D. Green ◽  
Catherine Cheze Le Rest ◽  
Benjamin Rosen ◽  
Issam El Naqa
Keyword(s):  
Clinical Trial ◽  
Trial Design ◽  
Clinical Trial Design

Reproductive Effects of Low-to-Moderate Medical Radiation Exposure

2012 ◽  
Vol 19 (36) ◽  
pp. 6171-6177 ◽  
Author(s):  
G. Latini ◽  
L. Dipaola ◽  
A. Mantovani ◽  
E. Picano
Keyword(s):  
Radiation Exposure ◽  
Reproductive Effects ◽  
Medical Radiation ◽  
Medical Radiation Exposure
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