Aviation promotes trade and tourism by connecting regions, people, and countries. Having a functional and efficient airport pavement network is important to improve aviation traffic and to provide safer mobility to almost 800 million passengers travelling in the U.S. per year. The Federal Aviation Administration has initiated and actively been participating in many projects to further advance pavement design and performance to meet user requirements. To accomplish that, quantitative data are needed; such data may be collected from the pavement response to gear and environment loading. In this study, responses from four instrumented taxiway concrete slabs at John F. Kennedy International Airport were analyzed. The collected data were used to develop machine-learning (ML) based prediction models to compute the temperature, curling and bending strains within pavement. The ML models were developed using the support vector machine (SVM) algorithm. The results showed that SVM based ML models can predict pavement responses with a high accuracy and low computation time. Furthermore, in the case of feeding more data from various airports, ML models have proven to be a promising technique for pavement analysis engine for future airport pavement design frameworks. This study also produces recommendations for future data collection projects to have well-designed databases for data-driven models development.