Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of Hiv Infection

2003 ◽  
Author(s):  
Erik De Clercq
Keyword(s):  
Hiv Infection ◽  
Antiviral Agents

Dendronized PLGA nanoparticles with anionic carbosilane dendrons as antiviral agents against HIV infection

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73817-73826 ◽  
Author(s):  
Marta Galán ◽  
Cristina Fornaguera ◽  
Paula Ortega ◽  
Gabriela Calderó ◽  
Raquel Lorente ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Antiviral Agents ◽  
Plga Nanoparticles ◽  
Anti Hiv Agents ◽  
Anti Hiv

PLGA nanoparticles functionalized with carbosilane anionic dendrons have been prepared. The biocompatibility and HIV activity have been explored in PBMC and HEC-1A cells. The results indicate that these systems are powerful anti-HIV agents.

Can HIV infection be eradicated through use of potent antiviral agents?

2010 ◽  
Vol 23 (6) ◽  
pp. 628-632 ◽  
Author(s):  
Lina Josefsson ◽  
Viktor Dahl ◽  
Sarah Palmer
Keyword(s):  
Hiv Infection ◽  
Antiviral Agents

scholarly journals Griffithsin-Modified Electrospun Fibers as a Delivery Scaffold To Prevent HIV Infection

2016 ◽  
Vol 60 (11) ◽  
pp. 6518-6531 ◽  
Author(s):  
Tiffany N. Grooms ◽  
Hung R. Vuong ◽  
Kevin M. Tyo ◽  
Danial A. Malik ◽  
Lee B. Sims ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Antiviral Agents ◽  
Electrospun Fibers ◽  
Virus Infections ◽  
Sexually Transmitted ◽  
Treatment Regimens ◽  
Potent Inhibition ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACTDespite current prophylactic strategies, sexually transmitted infections (STIs) remain significant contributors to global health challenges, spurring the development of new multipurpose delivery technologies to protect individuals from and treat virus infections. However, there are few methods currently available to prevent and no method to date that cures human immunodeficiency virus (HIV) infection or combinations of STIs. While current oral and topical preexposure prophylaxes have protected against HIV infection, they have primarily relied on antiretrovirals (ARVs) to inhibit infection. Yet continued challenges with ARVs include user adherence to daily treatment regimens and the potential toxicity and antiviral resistance associated with chronic use. The integration of new biological agents may avert some of these adverse effects while also providing new mechanisms to prevent infection. Of the biologic-based antivirals, griffithsin (GRFT) has demonstrated potent inhibition of HIV-1 (and a multitude of other viruses) by adhering to and inactivating HIV-1 immediately upon contact. In parallel with the development of GRFT, electrospun fibers (EFs) have emerged as a promising platform for the delivery of agents active against HIV infection. In the study described here, our goal was to extend the mechanistic diversity of active agents and electrospun fibers by incorporating the biologic GRFT on the EF surface rather than within the EFs to inactivate HIV prior to cellular entry. We fabricated and characterized GRFT-modified EFs (GRFT-EFs) with different surface modification densities of GRFT and demonstrated their safety and efficacy against HIV-1 infectionin vitro. We believe that EFs are a unique platform that may be enhanced by incorporation of additional antiviral agents to prevent STIs via multiple mechanisms.

Myelodysplastic features in patients with long-term HIV infection and haemophilia

Haemophilia ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 47-52 ◽  
Author(s):  
O. Katsarou ◽  
E. Terpos ◽  
E. Patsouris ◽  
P. Peristeris ◽  
N. Viniou ◽  
...  
Keyword(s):  
Hiv Infection

Behavioural risk factors for HIV infection amongst blood donors in London

1996 ◽  
Vol 6 (1) ◽  
pp. 31-36 ◽  
Author(s):  
F. M. Cowan ◽  
A. M. Johnson ◽  
J. Wadsworth ◽  
M. Brennan
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Blood Donors ◽  
Behavioural Risk Factors

Human Immunodeficiency Virus (HIV) Infection in Children

1987 ◽  
Vol 1 (3) ◽  
pp. 381-395 ◽  
Author(s):  
Beverly Ryan ◽  
Edward Connor ◽  
Anthony Minnefor ◽  
Frank Desposito ◽  
James Oleske
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Immunodeficiency Virus
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