AIDS dementia complex (ADC) and HIV infection of the CNS: Pathophysiologically-based approach to treatment and evaluation

1997 ◽  
Vol 103 (1) ◽  
pp. 27
Author(s):  
R Price
Keyword(s):  
Hiv Infection ◽  
Aids Dementia Complex ◽  
Aids Dementia

scholarly journals HIV infection of macrophages and pathogenesis of AIDS dementia complex: interaction of the host cell and viral genotype

1997 ◽  
Vol 62 (1) ◽  
pp. 117-125 ◽  
Author(s):  
A. L. Cunningham ◽  
H. Naif ◽  
N. Saksena ◽  
G. Lynch ◽  
J. Chang ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Host Cell ◽  
Complex Interaction ◽  
Aids Dementia Complex ◽  
Viral Genotype ◽  
Aids Dementia

Cellular Basis of HIV Infection of the CNS and the AIDS Dementia Complex:

1995 ◽  
Vol 1 (1) ◽  
pp. 133-160 ◽  
Author(s):  
Margaret M. Esiri ◽  
Christine S. Morris
Keyword(s):  
Hiv Infection ◽  
Aids Dementia Complex ◽  
Cellular Basis ◽  
Aids Dementia

Human Immunodeficiency Virus Infection, Dementia and the Older Patient

1993 ◽  
Vol 27 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Graeme J. Kernutt ◽  
Amanda J. Price ◽  
Fiona K. Judd ◽  
Graham D. Burrows
Keyword(s):  
Hiv Infection ◽  
Aids Dementia Complex ◽  
Aetiological Factor ◽  
Older Individuals ◽  
Older Person ◽  
Alzheimer Type ◽  
Subcortical Dementia ◽  
Aids Dementia ◽  
Immunodeficiency Virus ◽  
The Many

Australian statistics have shown that 10.9% of AIDS cases have occurred in the 50 years and over age group. To date little attention has been given to the many issues surrounding HIV infection in the older population, for example, the failure to consider HIV as an aetiological factor in the older person presenting with neuropsychiatric disorder and the potential for misdiagnosis of AIDS dementia complex as dementia of the Alzheimer type. This paper includes a discussion of the clinical features of the AIDS dementia complex, its resemblance to the syndrome of “subcortical dementia”, and review of the literature reporting dementia as the presenting feature of HIV infection in older individuals.

HIV Infection of the Brain Microvasculature and Its Contribution to the AIDS Dementia Complex

1995 ◽  
Vol 1 (1) ◽  
pp. 85-99 ◽  
Author(s):  
Ashlee V. Moses ◽  
Stephan G. Stenglein ◽  
Jay A. Nelson
Keyword(s):  
Hiv Infection ◽  
Aids Dementia Complex ◽  
Aids Dementia ◽  
Brain Microvasculature ◽  
The Brain

Zidovudine treatment of the AIDS dementia complex: Results of a placebo-controlled trial

1993 ◽  
Vol 33 (4) ◽  
pp. 343-349 ◽  
Author(s):  
John J. Sidtis ◽  
Constantine Gatsonis ◽  
Richard W. Price ◽  
Elyse J. Singer ◽  
Ann C. Collier ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Aids Dementia Complex ◽  
Aids Dementia ◽  
Zidovudine Treatment

scholarly journals Interleukin-6 and granulocyte macrophage-csf in the cerebrospinal fluid from hiv infected subjects with involvement of the central nervous system

1992 ◽  
Vol 50 (2) ◽  
pp. 180-182 ◽  
Author(s):  
O. Perrella ◽  
M. Guerriero ◽  
E. Izzo ◽  
M. Soscia ◽  
P. B. Carrieri
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Interleukin 6 ◽  
Neurological Diseases ◽  
Aids Dementia Complex ◽  
Gm Csf ◽  
Aids Dementia ◽  
High Incidence ◽  
The Central Nervous System ◽  
Csf Levels

We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.

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