Control Of Parathyroid Function By Dopamine

2019 ◽  
pp. 99-116
Author(s):  
E. M. Brown ◽  
C. J. Chen ◽  
H. B. Niznik ◽  
E. L. Fogel ◽  
D. Hawkins
Keyword(s):  
2018 ◽  
Vol 24 ◽  
pp. 226-227
Author(s):  
Ayotunde Ale ◽  
Olatunbosum Olawale ◽  
Onyido Okwuchi ◽  
Sunday Ogundele ◽  
Anthonia Ogbera

2020 ◽  
Vol 71 (6) ◽  
pp. 397-404
Author(s):  
Ryosuke Takahashi ◽  
Hiroaki Kawabe ◽  
Nobuaki Koide ◽  
Kazuchika Ohno ◽  
Yosuke Ariizumi ◽  
...  

2021 ◽  
pp. 1-9
Author(s):  
Mechteld C. de Jong ◽  
Leyre Lorente-Poch ◽  
Joan Sancho-Insenser ◽  
Virginia Rozalén García ◽  
Caroline Brain ◽  
...  

Background: Parathyroid failure after total thyroidectomy is the commonest adverse event amongst both children and adults. The phenomenon of late recovery of parathyroid function, especially in young patients with persistent hypoparathyroidism, is not well understood. This study investigated differences in rates of parathyroid recovery in children and adults and factors influencing this. Methods: A joint dual-centre database of patients who underwent a total thyroidectomy between 1998 and 2018 was searched for patients with persistent hypoparathyroidism, defined as dependence on oral calcium and vitamin D supplementation at 6 months. Demographic, surgical, pathological, and biochemical data were collected and analysed. <F00_Regular>Parathyroid Glands Remaining</F00_Regular> in Situ (PGRIS) score was calculated. Results: Out of 960 patients who had total thyroidectomy, 94 (9.8%) had persistent hypoparathyroidism at 6 months, 23 (24.5%) children with a median [range] age 10 [0–17], and 71 (75.5%) adults aged 55 [25–82] years, respectively. Both groups were comparable regarding sex, indication, extent of surgery, and PGRIS score. After a median follow-up of 20 months, the parathyroid recovery rate was identical for children and adults (11 [47.8%] vs. 34 [47.9%]; p = 0.92). Sex, extent, and indication for surgery had no effect on recovery (all p > 0.05). PGRIS score = 4 (HR = 0.48) and serum calcium >2.25 mmol/L (HR = 0.24) at 1 month were associated with a decreased risk of persistent hypoparathyroidism on multivariate analysis (p < 0.05). Conclusion: Almost half of patients recovered from persistent hypoparathyroidism after 6 months; therefore, the term persistent instead of permanent hypoparathyroidism should be used. Recovery rates of parathyroid function in children and adults were similar. Regardless of age, predictive factors for recovery were PGRIS score = 4 and a serum calcium >2.25 mmol/L at 1 month.


1967 ◽  
Vol 1 (1) ◽  
pp. 219-228 ◽  
Author(s):  
Lawrence G. Raisz ◽  
Donald R. Taves
Keyword(s):  

2009 ◽  
Vol 24 (4) ◽  
pp. 693-701 ◽  
Author(s):  
Natalia O Kuchuk ◽  
Natasja M van Schoor ◽  
Saskia M Pluijm ◽  
Arkadi Chines ◽  
Paul Lips

1987 ◽  
Vol 5 (2) ◽  
pp. 287-297
Author(s):  
Priscilla Hensel ◽  
Michael F. Roizen
Keyword(s):  

1977 ◽  
Vol 86 (4) ◽  
pp. 768-783 ◽  
Author(s):  
I. Transbø ◽  
F. Schønau Jørgensen ◽  
I. Hornum ◽  
N. Keiding

ABSTRACT The limited usefulness of radioimmunoassays of parathyroid hormone in the differential diagnosis of hypercalcaemia invites the use of methods measuring effects of parathyroid hormone (PTH). Data from 4–5-day metabolic studies in 107 hypercalcaemic patients (78 retrospective and 29 prospective cases) were combined in a hypercalcaemia discrimination index (HDI). HDI = (urine calcium (mg/24 h) x 100 x serum phosphate (mg/100 ml))/(serum total calcium (mg/100 ml) x 24-h clearance of creatinine (ml/min)) expresses in one figure the combined actions of PTH on the renal handling of calcium and on serum phosphate. A multivariate analysis confirmed that HDI offered optimal discrimination. An identical discrimination was observed in the prospective series. In the complete series HDI = 137 was the optimal discrimination point. Classification of the patients as having hyperparathyroidism (HPT) or pseudohyperparathyroidism (P-HPT) (< 137) or non-parathyroid hypercalcaemia (NON-PTH) (≧ 137) corresponded in 100 out of 107 patients (93.5%) with the final clinical diagnosis. The effects on HDI of sex, age, season, urine losses, high calcium intake and use of thiazides were also evaluated. HDI appears to be a valuable tool in the endocrine evaluation of hypercalcaemic patients. Used in combination with radioimmunoassays measuring genuine but not ectopic PTH HDI may serve to classify hypercalcaemic patients within the following 3 subgroups: HPT, P-HPT and NON-PTH.


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