Renal, thyroid and parathyroid function during lithium treatment: laboratory tests in 207 people treated for 1?30 years

1995 ◽  
Vol 91 (1) ◽  
pp. 48-51 ◽  
Author(s):  
G. Kallner ◽  
U. Petterson
Keyword(s):  
Laboratory Tests ◽  
Lithium Treatment ◽  
Parathyroid Function

scholarly journals Lithium-Associated Hypercalcemia Presenting with Neuropsychiatric Manifestations in a Patient with Bipolar Disorder

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Roukaya Benjelloun ◽  
Imane Motaib ◽  
Yassine Otheman
Keyword(s):  
Bipolar Disorder ◽  
Adverse Effects ◽  
Lithium Treatment ◽  
Neuropsychiatric Symptoms ◽  
Parathyroid Function ◽  
Neuropsychiatric Manifestations

One of the overlooked adverse effects of lithium treatment is neuropsychiatric manifestations induced by hypercalcemia (LAH). Here, we present the case of a patient, with bipolar disorder under lithium, who presented with neuropsychiatric symptoms that revealed hyperparathyroidism-induced hypercalcemia. This case illustrates the importance of monitoring parathyroid function and calcium levels in patients under lithium, especially in premenopaused women. LAH may mimic symptoms of manic episodes and should be sought in the case of brutal onset of confusion, anxiety, and/or hallucinations in the course of a bipolar disorder.

scholarly journals Dementia Improvement after Primary Hyperparathyroidism Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Claudio Voci
Keyword(s):  
Computed Tomography ◽  
Major Depressive Disorder ◽  
Primary Hyperparathyroidism ◽  
Diagnostic Tests ◽  
Laboratory Tests ◽  
Sleep Disturbances ◽  
Lithium Treatment ◽  
Tension Headache ◽  
Parathyroid Glands ◽  
Major Depressive

This is the case of a 76-year-old man admitted to hospital in a delirium state, previously diagnosed with a major depressive disorder at an age of 50 years, treated for years for chronic tension headache. The computed tomography of the head resulted negative. Inpatient laboratory tests revealed a mild hypercalcemia. Due to the progression of the disease (delirium state, dementia, tension headache, and depression), he was again admitted to hospital. The patient showed dysarthria, postural tremors, mirror movements and palmar hyperhidrosis, mild ataxia when walking, and rigidity. Sleep disturbances were also observed. He underwent several clinical diagnostic tests, which resulted negative. After more than 2 years, the ultrasound of the neck identified enlarged parathyroid glands. The patient was surgically treated, and three parathyroid glands were removed. Parathyroidectomy and lithium treatment resulted in improvement of cognitive functions. In elderly patients, concomitant presence of cognitive dysfunction may mask the underlying primary hyperparathyroidism.

scholarly journals Lithium in the treatment of bipolar disorder - monitoring of the adverse effects

2020 ◽  
Vol 73 (1-2) ◽  
pp. 49-53
Author(s):  
Milana Okanovic ◽  
Olga Zivanovic ◽  
Mina Cvjetkovic-Bosnjak ◽  
Vladimir Knezevic ◽  
Djendji Siladji ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Adverse Effects ◽  
Lithium Treatment ◽  
Lithium Therapy ◽  
Parathyroid Function ◽  
First Choice ◽  
Clinically Significant ◽  
American Academy Of Neurology

Introduction. Lithium therapy remains the gold standard in the treatment of bipolar disorder and clinical guidelines recommend it as the first choice for maintenance treatment of bipolar disorder. However, the use of lithium has decreased over the years, mainly due to the fear of its adverse effects. The aim of this paper was to review current literature data for the monitoring and overcoming side effects of lithium therapy in order to provide contemporary evidence for adequate lithium use. Material and Methods. A literature review of lithium therapy in bipolar disorder, using both Medline and manual searches, was performed. Classification of studies, in relation to their quality, was performed using the guidelines established by the American Academy of Neurology. Results. Despite methodological limitations of recent studies, there is irrefutable evidence that lithium therapy can cause toxicity and side effects related to renal, thyroid and parathyroid function, as well as weight gain. Conclusion. There is clear evidence that lithium can cause various side effects, but clinically significant conditions in this regard are rare and successfully treated. Literature data confirm strong efficacy of lithium and suggest its wider use in bipolar disorder. By following clinical recommendations and careful monitoring during lithium treatment, the risk of serious side effects is low compared to its efficacy.

Hyperthyroidism after Treatment with Lithium

1993 ◽  
Vol 38 (9) ◽  
pp. 599-602 ◽  
Author(s):  
E. Persad ◽  
N. Forbath ◽  
H. Merskey
Keyword(s):  
Laboratory Tests ◽  
Thyroid Dysfunction ◽  
Clinical Observation ◽  
Lithium Treatment ◽  
Graves Disease ◽  
Atypical Form ◽  
Early Stages ◽  
Unusual Association

The association between treatment with lithium and hypothyroidism is well documented. Reports of hyperthyroidism are rare and it is less well known among patients treated with lithium. It may be overlooked simply because the clinician will be watching for hypothyroidism, the reverse phenomenon. This paper describes the cases of four patients who have been on long term lithium treatment, all of whom developed Graves’ disease, or an atypical form of hyperthyroidism. Some suggestions are offered to account for the mechanism underlying this unusual association. Although hyperthyroidism may be rare among patients receiving lithium, astute clinical observation and appropriate laboratory tests are called for to detect the early stages of such thyroid dysfunction and to provide appropriate intervention.

Abstract #1017 Parathyroid Function in Hyperthyroidism in Relation to Calcium-Phosphorus Metabolism

2018 ◽  
Vol 24 ◽  
pp. 226-227
Author(s):  
Ayotunde Ale ◽  
Olatunbosum Olawale ◽  
Onyido Okwuchi ◽  
Sunday Ogundele ◽  
Anthonia Ogbera
Keyword(s):  
Phosphorus Metabolism ◽  
Parathyroid Function ◽  
Calcium Phosphorus

Critical limb ischaemia in diabetes: definition, assessment, prognosis

VASA ◽  
2001 ◽  
Vol 30 (Supplement 58) ◽  
pp. 21-27
Author(s):  
Luther
Keyword(s):  
Diabetic Foot ◽  
Laboratory Tests ◽  
Critical Limb Ischaemia ◽  
Limb Ischaemia ◽  
Clinical Use ◽  
Arterial Reconstruction ◽  
Arterial Circulation ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
Fontaine Classification

In diabetic foot disease, critical limb ischaemia (CLI) cannot be precisely described using established definitions. For clinical use, the Fontaine classification complemented with any objective verification of a reduced arterial circulation is sufficient for decision making. For scientific purposes, objective measurement criteria should be reported. Assessment of CLI should rely on the physical examination of the limb arteries, complemented by laboratory tests like the shape of the PVR curve at ankle or toe levels, and arteriography. The prognosis of CLI in diabetic foot disease depends on the success of arterial reconstruction. The best prognosis for the patients is with a preserved limb. Reconstructive surgery is the best choice for the majority of patients.

The Reliability of Retrieval-Induced Forgetting

2012 ◽  
Vol 17 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Rosalind Potts ◽  
Robin Law ◽  
John F. Golding ◽  
David Groome
Keyword(s):  
Individual Differences ◽  
Recognition Test ◽  
Laboratory Tests ◽  
The Other ◽  
Clinical Factors ◽  
Test Items ◽  
T1 And T2 ◽  
Test Materials ◽  
Induced Forgetting

Retrieval-induced forgetting (RIF) refers to the finding that the retrieval of an item from memory impairs the retrieval of related items. The extent to which this impairment is found in laboratory tests varies between individuals, and recent studies have reported an association between individual differences in the strength of the RIF effect and other cognitive and clinical factors. The present study investigated the reliability of these individual differences in the RIF effect. A RIF task was administered to the same individuals on two occasions (sessions T1 and T2), one week apart. For Experiments 1 and 2 the final retrieval test at each session made use of a category-cue procedure, whereas Experiment 3 employed category-plus-letter cues, and Experiment 4 used a recognition test. In Experiment 2 the same test items that were studied, practiced, and tested at T1 were also studied, practiced, and tested at T2, but for the remaining three experiments two different item sets were used at T1 and T2. A significant RIF effect was found in all four experiments. A significant correlation was found between RIF scores at T1 and T2 in Experiment 2, but for the other three experiments the correlations between RIF scores at T1 and T2 failed to reach significance. This study therefore failed to find clear evidence for reliable individual differences in RIF performance, except where the same test materials were used for both test sessions. These findings have important implications for studies involving individual differences in RIF performance.

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