scholarly journals Vitamin D Status, Parathyroid Function, Bone Turnover, and BMD in Postmenopausal Women With Osteoporosis: Global Perspective

2009 ◽  
Vol 24 (4) ◽  
pp. 693-701 ◽  
Author(s):  
Natalia O Kuchuk ◽  
Natasja M van Schoor ◽  
Saskia M Pluijm ◽  
Arkadi Chines ◽  
Paul Lips
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Global Perspective ◽  
Vitamin D Status ◽  
Parathyroid Function

scholarly journals Vitamin D status of 51–75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover

2006 ◽  
Vol 9 (2) ◽  
pp. 225-233 ◽  
Author(s):  
Tom R Hill ◽  
Maria M O'Brien ◽  
Christel Lamberg-Allardt ◽  
Jette Jakobsen ◽  
Mairead Kiely ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Elevated Serum ◽  
Dietary Calcium Intake ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Serum Pth ◽  
Biochemical Indices

AbstractObjectivesTo assess the vitamin D status of Irish postmenopausal women during wintertime, and to examine its relationship with serum parathyroid hormone (PTH) and biochemical markers of bone turnover. In addition, the determinants of wintertime serum 25-hydroxyvitamin D (25OH–D) levels in these women were investigated.DesignA cross-sectional observational study.SettingCork City, Ireland (52°N).SubjectsNinety-five apparently healthy, free-living postmenopausal women (aged 51–75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism.ResultsForty-eight per cent and 7% of women had serum 25OH–D levels <50 nmol l−1and <25 nmol l−1, respectively. 25OH–D levels in these women were positively associated with dietary calcium intake (P= 0.0002) and use of vitamin D-containing supplements (P= 0.031), and negatively associated with cigarette smoking (P= 0.027) and body mass index (BMI) (P= 0.030). Low serum 25OH-D levels (<50 nmol l−1) were associated (P<0.01) with elevated serum PTH levels. There were no significant differences in urinary pyridinium crosslinks or serum osteocalcin, biochemical indices of bone turnover, between subjects with serum 25OH–D levels above or below 50 nmol l−1.ConclusionsA high proportion of Irish postmenopausal women had low vitamin D status (< 50 nmol l−1) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers. Use of regular low-dose supplemental vitamin D, meeting daily calcium recommendations, cessation of smoking and maintaining BMI in the normal range are important factors that could help maintain adequate vitamin D levels during wintertime in these women.

Seasonal Changes in Vitamin D Status and Bone Turnover in Healthy Irish Postmenopausal Women

2007 ◽  
Vol 77 (5) ◽  
pp. 320-325 ◽  
Author(s):  
Hill ◽  
McCarthy ◽  
Jakobsen ◽  
Lamberg-Allardt ◽  
Kiely ◽  
...  
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Seasonal Changes ◽  
Late Summer ◽  
Late Winter ◽  
Vitamin D Status ◽  
Old Irish ◽  
The Impact

Objectives: To examine the effect of season on biochemical markers of bone turnover in 51-to 75-year-old Irish women and to investigate whether such changes are related to vitamin D status. Design: Longitudinal observational study. Setting: Cork, Ireland (52ºN). Subjects: 76 apparently healthy, free-living postmenopausal women (aged 51–75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism. Results: Serum 25-hydroxyvitamin D [S-25(OH)D] showed a clear seasonal variation with significantly higher (p < 0.001) values during late summer than late winter. Both urinary pyridinoline (Ur-Pyr) (p < 0.01) and deoxypyridinoline (Ur-Dpyr) (p < 0.001), but not serum parathyroid hormone or osteocalcin, showed a marked seasonal variation with lowest values during late-summer. Stratifying women into those with S-25(OH)D levels ≥ or < 50 nmol/L (vitamin D adequate and inadequate, respectively) during late-winter, showed that Ur-Pyr and Ur-Dpyr in both groups were significantly (p < 0.05) lower during late summer, and the magnitude of the reduction from winter to summer was similar in both groups. Conclusion: Seasonal changes in bone resorption markers appeared to be linked to seasonal changes in vitamin D status. Further research is needed to investigate the impact of these changes on risk of bone loss and fracture.

scholarly journals Influence of Vitamin D Status on the Effect of Statins on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women

2014 ◽  
Vol 99 (9) ◽  
pp. 3304-3309 ◽  
Author(s):  
José L. Hernández ◽  
José M. Olmos ◽  
Galo Romaña ◽  
Javier Llorca ◽  
Josefina Martínez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Turnover Markers
Sign in / Sign up

Export Citation Format

Share Document